Increase in pladienolide D production rate using a Streptomyces strain overexpressing a cytochrome P450 gene

Journal of Bioscience and Bioengineering

Volumn 105, Issue 6, 2008, Pages 649-654

  Machida, Kazuhiro ^a   Aritoku, Yasuhide ^a   Nakashima, Takashi ^a   Arisawa, Akira ^a   Tsuchida, Toshio ^a  

^a MERCIAN CORPORATION   (Japan)

Author keywords

bacterial P450 expression system; biotransformation; cytochrome P450 monooxygenase; pladienolide; Streptomyces bungoensis A 1544

Indexed keywords

BIOTECHNOLOGY; HYDROXYLATION;

ANTI-TUMOR ACTIVITIES; CONTROL STRAIN; CYTOCHROME P450 (CYP); HYDROXYLASE; IN-VITRO; IN-VIVO; MACROLIDES; PLATENSIS; PRODUCTION LEVELS; PRODUCTION RATES;

STRAIN RATE;

CYTOCHROME P450; NATURAL PRODUCT; PLADIENOLIDE B; PLADIENOLIDE D;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOSYNTHESIS; BIOTRANSFORMATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; PSMA GENE; STREPTOMYCES; STREPTOMYCES BUNGOENSIS;

CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; GENETIC ENGINEERING; MACROLIDES; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; STREPTOMYCES; UP-REGULATION;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES BUNGOENSIS; STREPTOMYCES PLATENSIS;

EID: 47149105113     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1263/jbb.105.649     Document Type: Article

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