Pharmacokinetic and pharmacodynamic study of morphine and morphine 6-glucuronide after oral and intravenous administration of morphine in children with cancer

Biopharmaceutics and Drug Disposition

Volumn 30, Issue 3, 2009, Pages 99-106

  Mashayekhi, Simin O ^a   Ghandforoush Sattari, Mohammadreza ^a   Routledge, Philip A ^b   Hain, Richard D W ^b  

^a UNIVERSITY OF TABRIZ   (Iran)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Children; Morphine; Morphine 6 glucuronide; Pharmacodynamics; Pharmacokinetics

Indexed keywords

MORPHINE; MORPHINE 6 GLUCURONIDE;

ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; CANCER PAIN; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONSTIPATION; CONTINUOUS INFUSION; DIZZINESS; DROWSINESS; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DYSPNEA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MUCOSA INFLAMMATION; NAUSEA AND VOMITING; PRURITUS; RESPIRATORY TRACT DISEASE; SHORT COURSE THERAPY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE RETENTION; VOMITING;

ADMINISTRATION, ORAL; ADOLESCENT; BIOTRANSFORMATION; CHILD; CHILD, PRESCHOOL; FEMALE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; MORPHINE; MORPHINE DERIVATIVES; NARCOTICS; NAUSEA; NEOPLASMS; PAIN; PAIN MEASUREMENT; PRURITUS; SLEEP STAGES; URINARY RETENTION; VOMITING;

EID: 65549153584     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.649     Document Type: Article

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