메뉴 건너뛰기




Volumn 48, Issue 1, 1999, Pages 37-42

Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children

Author keywords

Cerebrospinal fluid; Children; Morphine; Morphine 6 glucuronide; Plasma

Indexed keywords

MORPHINE; MORPHINE 6 GLUCURONIDE; OPIATE;

EID: 0032986840     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00948.x     Document Type: Article
Times cited : (41)

References (50)
  • 3
    • 0023701349 scopus 로고
    • Morphine-6-glucuronide: Analgesic effects and receptor binding profile in rats
    • 3 Abbott, FV, Palmour, RM. Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats. Life Sci 1988; 43: 1685-1695.
    • (1988) Life Sci , vol.43 , pp. 1685-1695
    • Abbott, F.V.1    Palmour, R.M.2
  • 4
    • 0024369341 scopus 로고
    • Pharmacological characterization of morphine -6-beta glucuronide, a very potent morphine metabolite
    • 4 Paul, D, Standifer, KM, Inturrisi, CE, Pasternak, GW. Pharmacological characterization of morphine -6-beta glucuronide, a very potent morphine metabolite. J Pharmacol Exp Ther 1989; 251: 477-483.
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 477-483
    • Paul, D.1    Standifer, K.M.2    Inturrisi, C.E.3    Pasternak, G.W.4
  • 5
    • 0026059585 scopus 로고
    • Antinociceptive and ventilatory effects of the morphine metabolites: Morphine-6-glucuronide and morphine-3-glucuronide
    • 5 Gong, QL, Hedner, T, Hedner, J, Bjorkman, R, Nordberg, G. Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide. Eur J Pharmacol 1991; 193: 47-56.
    • (1991) Eur J Pharmacol , vol.193 , pp. 47-56
    • Gong, Q.L.1    Hedner, T.2    Hedner, J.3    Bjorkman, R.4    Nordberg, G.5
  • 6
    • 1542768293 scopus 로고
    • Analgesic activity of morphine-6-glucuronide
    • 6 Osborne, R, Joel, S, Trew, D, Slevin, M. Analgesic activity of morphine-6-glucuronide. Lancet 1988; i: 828.
    • (1988) Lancet , vol.1 , pp. 828
    • Osborne, R.1    Joel, S.2    Trew, D.3    Slevin, M.4
  • 9
    • 0025784962 scopus 로고
    • Toxicity and pharmacokinetics of morphine and morphine-6-glucuronide
    • 9 Davis, CL. Toxicity and pharmacokinetics of morphine and morphine-6-glucuronide. Br J Anaesthesia 1991; 67: 362-363.
    • (1991) Br J Anaesthesia , vol.67 , pp. 362-363
    • Davis, C.L.1
  • 10
    • 0025904196 scopus 로고
    • Morphine-6-glucuronide: Effect on ventilation in normal volunteers
    • 10 Peat, SJ, Hanna, MH, Knibb, AA, Ponte, J. Morphine-6-glucuronide: effect on ventilation in normal volunteers. Pain 1991; 45: 101-104.
    • (1991) Pain , vol.45 , pp. 101-104
    • Peat, S.J.1    Hanna, M.H.2    Knibb, A.A.3    Ponte, J.4
  • 11
    • 0013576448 scopus 로고
    • Disposition of morphine-6-glucuronide and morphine in healthy volunteers
    • 11 Hanna, MH, Peat, SJ, Knibb, A, Fung, C. Disposition of morphine-6-glucuronide and morphine in healthy volunteers. Br J Anaesth 1991; 64: 547-550.
    • (1991) Br J Anaesth , vol.64 , pp. 547-550
    • Hanna, M.H.1    Peat, S.J.2    Knibb, A.3    Fung, C.4
  • 12
    • 0001223553 scopus 로고
    • Comparison of the respiratory depression induced by morphine and its active metabolite morphine-6-glucuronide
    • 12 Thompson, PI, John, I, Wedzicha, JA, Slevin, ML. Comparison of the respiratory depression induced by morphine and its active metabolite morphine-6-glucuronide. Br J Cancer 1990; 62: 484.
    • (1990) Br J Cancer , vol.62 , pp. 484
    • Thompson, P.I.1    John, I.2    Wedzicha, J.A.3    Slevin, M.L.4
  • 13
    • 0026557354 scopus 로고
    • Explanation at the opioid receptor level for differing toxicity of morphine and morphine-6-glucuronide
    • 13 Hucks, D, Thompson, PI, McLoughlin, L, et al. Explanation at the opioid receptor level for differing toxicity of morphine and morphine-6-glucuronide. Br J Cancer 1992; 65: 122-126.
    • (1992) Br J Cancer , vol.65 , pp. 122-126
    • Hucks, D.1    Thompson, P.I.2    McLoughlin, L.3
  • 14
    • 0022548404 scopus 로고
    • Minireview: Multipe mu opiate receptors
    • 14 Pasternak, GW, Wood, PJ. Minireview: multipe mu opiate receptors. Life Sci 1986; 38: 1889.
    • (1986) Life Sci , vol.38 , pp. 1889
    • Pasternak, G.W.1    Wood, P.J.2
  • 15
    • 0024446001 scopus 로고
    • The pharmacologic management of pain in children
    • 15 Yaster, M, Deshpande, JK, Maxwell, LG. The pharmacologic management of pain in children. Comp Ther 1989; 15: 14-26.
    • (1989) Comp Ther , vol.15 , pp. 14-26
    • Yaster, M.1    Deshpande, J.K.2    Maxwell, L.G.3
  • 16
    • 0028240543 scopus 로고
    • Evaluation of a differential radioimmunoassay technique for the determination of morphine and morphine-6-glucuronide in human plasma
    • 16 Chapman, DJ, Joel, SP, Aherne, GW. Evaluation of a differential radioimmunoassay technique for the determination of morphine and morphine-6-glucuronide in human plasma. J Pharmaceut Biomed Anal 1994; 12: 353-360.
    • (1994) J Pharmaceut Biomed Anal , vol.12 , pp. 353-360
    • Chapman, D.J.1    Joel, S.P.2    Aherne, G.W.3
  • 17
    • 0029060944 scopus 로고
    • A specific radioimmunoassay for the determination of morphine-6-glucuronide in human plasma
    • 17 Chapman, DJ, Cross, MJ, Joel, SP, Aherne, GW. A specific radioimmunoassay for the determination of morphine-6-glucuronide in human plasma. Ann Clin Biochem 1995; 32: 297-302.
    • (1995) Ann Clin Biochem , vol.32 , pp. 297-302
    • Chapman, D.J.1    Cross, M.J.2    Joel, S.P.3    Aherne, G.W.4
  • 18
    • 0023786649 scopus 로고
    • An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites
    • 18 Joel, SP, Osborne, RJ, Slevin, ML. An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites. J Chromatogr 1988; 430: 394-399.
    • (1988) J Chromatogr , vol.430 , pp. 394-399
    • Joel, S.P.1    Osborne, R.J.2    Slevin, M.L.3
  • 21
    • 0021079421 scopus 로고
    • Pharmacokinetics of intravenous morphine in balanced anesthesia: Studies on children
    • 21 Vanderberghe, H, MacLeod, S, Chinyanga, M, Endrenyi, L, Soldin, S. Pharmacokinetics of intravenous morphine in balanced anesthesia: studies on children. Drug Metab Rev 1983; 14: 887-903.
    • (1983) Drug Metab Rev , vol.14 , pp. 887-903
    • Vanderberghe, H.1    MacLeod, S.2    Chinyanga, M.3    Endrenyi, L.4    Soldin, S.5
  • 22
    • 0021847625 scopus 로고
    • Variation in morphine pharmacokinetics in children with cancer
    • 22 Nahata, MC, Miser, AW, Reuning, RH. Variation in morphine pharmacokinetics in children with cancer. Dev Pharmacol Therapeutics 1985; 8: 182-188.
    • (1985) Dev Pharmacol Therapeutics , vol.8 , pp. 182-188
    • Nahata, M.C.1    Miser, A.W.2    Reuning, R.H.3
  • 23
    • 0023552889 scopus 로고
    • Cerebrospinal fluid and plasma pharmacokinetics of morphine infusions in pediatric cancer patients and rhesus monkeys
    • 23 Greene, RF, Miser, AW, Lester, CM, Balis, TM, Poplack, DG. Cerebrospinal fluid and plasma pharmacokinetics of morphine infusions in pediatric cancer patients and rhesus monkeys. Pain 1987; 30: 339-348.
    • (1987) Pain , vol.30 , pp. 339-348
    • Greene, R.F.1    Miser, A.W.2    Lester, C.M.3    Balis, T.M.4    Poplack, D.G.5
  • 24
    • 0023152905 scopus 로고
    • Morphine pharmacokinetics in early infancy
    • 24 Lynn, AM, Slattery, JT. Morphine pharmacokinetics in early infancy. Anesthesiol 1987; 66: 136-139.
    • (1987) Anesthesiol , vol.66 , pp. 136-139
    • Lynn, A.M.1    Slattery, J.T.2
  • 28
    • 0026486359 scopus 로고
    • Analgesia in children with sickle cell crisis: Comparison of intermittent opioids versus continuous infusion of morphine and placebo controlled study of oxygen inhalation
    • 28 Robieux, IC, Kellner, JD, Coppes, MJ, et al. Analgesia in children with sickle cell crisis: comparison of intermittent opioids versus continuous infusion of morphine and placebo controlled study of oxygen inhalation. Pediatric Hematolgy Oncol 1992; 9: 317-326.
    • (1992) Pediatric Hematolgy Oncol , vol.9 , pp. 317-326
    • Robieux, I.C.1    Kellner, J.D.2    Coppes, M.J.3
  • 30
    • 0019474330 scopus 로고
    • Pharmacokinetics of intravenous morphine in patients anaesthetised with enflurane-nitrous oxide
    • 30 Murphy, MR, Hug, CC. Pharmacokinetics of intravenous morphine in patients anaesthetised with enflurane-nitrous oxide. Anesthesiol 1981; 54: 187.
    • (1981) Anesthesiol , vol.54 , pp. 187
    • Murphy, M.R.1    Hug, C.C.2
  • 31
    • 0021254021 scopus 로고
    • Pharmacokinetics of single-dose iv morphine in normal volunteers and patients with end-stage renal failure
    • 31 Aitkenhead, AR, Vater, M, Achola, K, Cooper, CMS, Smith, G. Pharmacokinetics of single-dose iv morphine in normal volunteers and patients with end-stage renal failure. Br J Anaesth 1984; 56: 813-819.
    • (1984) Br J Anaesth , vol.56 , pp. 813-819
    • Aitkenhead, A.R.1    Vater, M.2    Achola, K.3    Cooper, C.M.S.4    Smith, G.5
  • 33
    • 0025179139 scopus 로고
    • Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life
    • 33 Bhat, R, Chari, G, Gulati, A, Aldana, O, Velamati, R, Bhargava, H. Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life. J Pediatrics 1990; 117: 477-481.
    • (1990) J Pediatrics , vol.117 , pp. 477-481
    • Bhat, R.1    Chari, G.2    Gulati, A.3    Aldana, O.4    Velamati, R.5    Bhargava, H.6
  • 36
    • 0000827655 scopus 로고
    • Concentrations of morphine, morphine metabolites and peptides in human CSF and plasma
    • 36 Venn, R, Michalkiewicz, A, Hardy, P, Wells, C. Concentrations of morphine, morphine metabolites and peptides in human CSF and plasma. Pain 1990; 5: S188.
    • (1990) Pain , vol.5
    • Venn, R.1    Michalkiewicz, A.2    Hardy, P.3    Wells, C.4
  • 38
    • 0024513853 scopus 로고
    • The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers
    • 38 Hoskin, PJ, Hanks, GW, Aherne, GW, Chapman, D, Littleton, P, Filshie, J. The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br J Clin Pharmacol 1989; 27: 499-505.
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 499-505
    • Hoskin, P.J.1    Hanks, G.W.2    Aherne, G.W.3    Chapman, D.4    Littleton, P.5    Filshie, J.6
  • 39
    • 0019946132 scopus 로고
    • Morphine glucuronidation in human fetal and adult liver
    • 39 Pacifici, GM, Säwe, J, Kager, L, Rane, A. Morphine glucuronidation in human fetal and adult liver. Eur J Clin Pharmacol 1982; 22: 553-558.
    • (1982) Eur J Clin Pharmacol , vol.22 , pp. 553-558
    • Pacifici, G.M.1    Säwe, J.2    Kager, L.3    Rane, A.4
  • 40
    • 0025826820 scopus 로고
    • Morphine-6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity
    • 40 Carrupt, P-A, Testa, B, Bechalany, A, El Tayar, N, Descas, P, Perrissoud, D. Morphine-6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity. J Med Chem 1991; 34: 1272-1275.
    • (1991) J Med Chem , vol.34 , pp. 1272-1275
    • Carrupt, P.-A.1    Testa, B.2    Bechalany, A.3    El Tayar, N.4    Descas, P.5    Perrissoud, D.6
  • 42
    • 0027224052 scopus 로고
    • Pharmacokinetics of morphine infusion in premature neonates
    • 42 Hartley, R, Green, M, Quinn, M, Levene, MI. Pharmacokinetics of morphine infusion in premature neonates. Arch Dis Childhood 1993; 69: 55-58.
    • (1993) Arch Dis Childhood , vol.69 , pp. 55-58
    • Hartley, R.1    Green, M.2    Quinn, M.3    Levene, M.I.4
  • 44
    • 0025190756 scopus 로고
    • Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide
    • 44 Osborne, R, Joel, S, Trew, D, Slevin, M. Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther 1990; 47: 12-19.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 12-19
    • Osborne, R.1    Joel, S.2    Trew, D.3    Slevin, M.4
  • 45
    • 0024339440 scopus 로고
    • Studies on morphine disposition: Influence of general anaesthesia on plasma concentrations of morphine and its metabolites
    • 45 Sear, JW, Hand, CW, Moore, RA, McQuay, HJ. Studies on morphine disposition: influence of general anaesthesia on plasma concentrations of morphine and its metabolites. Br J Anaesth 1989; 62: 22-27.
    • (1989) Br J Anaesth , vol.62 , pp. 22-27
    • Sear, J.W.1    Hand, C.W.2    Moore, R.A.3    McQuay, H.J.4
  • 46
    • 0023227229 scopus 로고
    • Explanation for potency of repeated oral doses of morphine
    • 46 Hanks, GW, Hoskin, PJ, Aherne, GW, Turner, P, Poulain, P. Explanation for potency of repeated oral doses of morphine. Lancet 1987; ii: 723-726.
    • (1987) Lancet , vol.2 , pp. 723-726
    • Hanks, G.W.1    Hoskin, P.J.2    Aherne, G.W.3    Turner, P.4    Poulain, P.5
  • 47
    • 0026091217 scopus 로고
    • Chronic morphine therapy for cancer pain: Plasma and cerebrospinal fluid morphine and morphine-6-glucuronide concentrations
    • 47 Portenoy, RK, Khan, E, Layman, M, et al. Chronic morphine therapy for cancer pain: plasma and cerebrospinal fluid morphine and morphine-6-glucuronide concentrations. Neurol 1991; 41: 1457-1461.
    • (1991) Neurol , vol.41 , pp. 1457-1461
    • Portenoy, R.K.1    Khan, E.2    Layman, M.3
  • 48
    • 0025955839 scopus 로고
    • Plasma morphine and morphine-6-glucuronide during chronic morphine therapy for cancer pain: Plasma profiles, steady-state concentrations and the consequences of renal failure
    • 48 Portenoy, RK, Foley, KM, Stulman, J, et al. Plasma morphine and morphine-6-glucuronide during chronic morphine therapy for cancer pain: plasma profiles, steady-state concentrations and the consequences of renal failure. Pain 1991; 47: 13-19.
    • (1991) Pain , vol.47 , pp. 13-19
    • Portenoy, R.K.1    Foley, K.M.2    Stulman, J.3
  • 50
    • 0028246011 scopus 로고
    • Management of common opioid side effects during long-term therapy of cancer pain
    • 50 Portenoy, RK. Management of common opioid side effects during long-term therapy of cancer pain. Ann Acad Med 1994; 23: 160-170.
    • (1994) Ann Acad Med , vol.23 , pp. 160-170
    • Portenoy, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.