Probing mutation-induced structural perturbations by refinement against residual dipolar couplings: Application to the U4 spliceosomal RNP complex

ChemBioChem

Volumn 10, Issue 6, 2009, Pages 1007-1014

  Kirkpatrick, John P ^a   Li, Ping ^b   Carlomagno, Teresa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Mutagenesis; NMR spectroscopy; Protein structures; Residual dipolar couplings; Spliceosome

Indexed keywords

RIBONUCLEOPROTEIN;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; MUTATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN STRUCTURE; RNA SPLICING;

BASE SEQUENCE; ELECTROPHORESIS; HUMANS; INVERTED REPEAT SEQUENCES; MODELS, MOLECULAR; MUTAGENESIS; MUTANT PROTEINS; MUTATION; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RNA, SMALL NUCLEAR;

EID: 65549147578     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800786     Document Type: Article

References (25)

1. N. Tjandra, J. G. Omichinski, A. M. Gronenborn, G. M. Clore, A. Bax, Nat. Struct. Biol. 1997, 4, 732.
2. J. R. Tolman, J. M. Flanagan, M. A. Kennedy, J. H. Prestegard, Proc. Natl. Acad. Sci. USA 1995, 92, 9279.
3. G. A. Mueller, W. Y. Choy, D. W. Yang, J. D. Forman-Kay, R. A. Venters, L. E. Kay, J. Mol. Biol. 2000, 300, 197.
4. N. R. Skrynnikov, N. K. Goto, D. W. Yang, W. Y. Choy, J. R. Tolman, G. A. Mueller, L. E. Kay, J. Mol. Biol. 2000, 295, 1265.
5. J.-C. Hus, D. Marion, M. Blackledge, J. Am. Chem. Soc. 2001, 123, 1541.
6. J.-C. Hus, D. Marion, M. Blackledge, J. Mol. Biol. 2000, 298, 927.
7. S. Nottrott, K. Hartmuth, P. Fabrizio, H. Urlaub, I. Vidovic, R. Ficner, R. Luhrmann, EMBO J. 1999, 18, 6119.
8. P. Bringmann, B. Appel, J. Rinke, R. Reuter, H. Theissen, R. Luhrmann, EMBO J. 1984, 3, 1357.
9. C. Hashimoto, J. A. Steitz, Nucleic Acids Res. 1984, 12, 3283.
10. I. Vidovic, S. Nottrott, K. Hartmuth, R. Luhrmann, R. Ficner, Mol. Cell 2000, 6, 1331.
11. S. Nottrott, H. Urlaub, R. Luhrmann, EMBO J. 2002, 21, 5527.
12. C. Schneider, C. L. Will, O. V. Makarova, E. M. Makarov, R. Luhrmann, Mol. Cell. Biol. 2002, 22, 3219.
13. A. Schultz, S. Nottrott, N. J. Watkins, R. Luhrmann, Mol. Cell. Biol. 2006, 26, 5146.
14. S. Liu, P. Li, O. Dybkov, S. Nottrott, K. Hartmuth, R. Luhrmann, T. Carlomagno, M. C. Wahl, Science 2007, 316, 115.
15. C. D. Schwieters, J. J. Kuszewski, G. M. Clore, Prog. Nucl. Magn. Reson. Spectrosc. 2006, 48, 47.
16. C. D. Schwieters, J. J. Kuszewski, N. Tjandra, G. M. Clore, J. Magn. Reson. 2003, 160, 65.
17. J. A. Losonczi, M. Andrec, M. W. F. Fischer, J. H. Prestegard, J. Magn. Reson. 1999, 138, 334.
18. M. Zweckstetter, A. Bax, J. Am. Chem. Soc. 2000, 122, 3791.
19. R. D. Seidel, J. C. Amor, R. A. Kahn, J. H. Prestegard, J. Biol. Chem. 2004, 279, 48307.
20. D. Frishman, P. Argos, Proteins Struct. Funct. Genet. 1995, 23, 566.
21. S. Grzesiek, A. Bax, J. Magn. Reson. 1992, 96, 432.
22. S. Grzesiek, A. Bax, J. Biomol. NMR 1993, 3, 185.
23. M. Ottiger, F. Delaglio, A. Bax, J. Magn. Reson. 1998, 131, 373.
24. K. Y. Ding, A. M. Gronenborn, J. Magn. Reson. 2002, 158, 173.
25. E. F. Pettersen, T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, T. E. Ferrin, J. Comput. Chem. 2004, 25, 1605.