Self-termination/anergic mechanisms in human basophils and mast cells

International Archives of Allergy and Immunology

Volumn 150, Issue 2, 2009, Pages 109-121

  MacGlashan Jr , Donald W ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Anergy; Basophil activation; Basophils; Desensitization; Fc receptor (high affinity IgE receptor); Human; Mast cell; Regulation; Signal transduction

Indexed keywords

IMMUNOGLOBULIN E;

BASOPHIL; CELL ACTIVATION; CELL STIMULATION; CLONAL ANERGY; DESENSITIZATION; HUMAN; MAST CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BASOPHILS; CELL DEGRANULATION; CLONAL ANERGY; DOWN-REGULATION; FEEDBACK, BIOCHEMICAL; HUMANS; IMMUNOGLOBULIN E; MAST CELLS; SIGNAL TRANSDUCTION;

EID: 65549145141     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000218114     Document Type: Review

References (65)

1. Jouvin MH, Adamczewski M, Numerof R, Letourneur O, Valle A, Kinet JP: Differential control of the tyrosine kinase lyn and syk by the two signaling chains of the high affinity immunoglobulin E receptor. J Biol Chem 1994; 269: 5918-5925.
2. Kihara H, Siraganian RP: Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J Biol Chem 1994; 269: 22427-22432.
3. Yamashita T, Mao SY, Metzger H: Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase. Proc Natl Acad Sci USA 1994; 91: 11251-11255.
4. Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T: The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 2007; 110: 2511-2519.
5. Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S,Maeda-Yamamoto M,Kawakami Y, Lowell CA, Ra C, Kawakami T: Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol 2005; 175: 6885-6892.
6. Odom S, Gomez G, Kovarova M, Furumoto Y, Ryan JJ, Wright HV, Gonzalez-Espinosa C, Hibbs ML, Harder KW, Rivera J: Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med 2004; 199: 1491-1502.
7. Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM: Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol 2004; 173: 100-112.
8. Gibbs BF, Grabbe J: Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. J Leukoc Biol 1999; 65: 883-890.
9. Miura, K, MacGlashan DW Jr: Phosphati-dylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils. Blood 2000; 96: 2199-2205.
10. Miura K, Lavens-Phillips S, MacGlashan DW Jr: Localizing a control region in the pathway to LTC4 secretion following stimulation of human basophils with anti-IgE antibody. J Immunol 2001; 167: 7027-7037.
11. Lichtenstein LM, De Bernardo R: IgE mediated histamine release: in vitro separation into two phases. Int Arch Allergy Appl Immunol 1971; 41: 56-71.
12. Sobotka AK, Dembo M, Goldstein B, Lich-tenstein LM: Antigen-specific desensitization of human basophils. J Immunol 1979; 122: 511-517.
13. MacGlashan DW Jr, Lichtenstein LM: The transition from specific to nonspecific desensitization in human basophils. J Immu-nol 1981; 127: 2410-2414.
14. Knol EF, Mul FP, Kuijpers TW, Verhoeven AJ, Roos D: Intracellular events in anti-IgE nonreleasing human basophils. J Allergy Clin Immunol 1992; 90: 92-103.
15. MacGlashan DW Jr: Two regions of down-regulation in the IgE-mediated signaling pathway in human basophils. J Immunol 2003; 170: 4814-4925.
16. MacGlashan DW Jr, Vilarino N: Nonspecific desensitization, functional memory and the characteristics of SHIP phosphorylation following IgE-mediated stimulation of human basophils. J Immunol 2006; 177: 1040-1051.
17. Kimura T, Sakamoto H, Appella E, Siraga-nian RP: The negative signaling molecule SH2 domain-containing inositol-polyphos-phate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J Biol Chem 1997; 272: 13991-13996.
18. Rauh MJ, Kalesnikoff J, Hughes M, Sly L, Lam V, Krystal G: Role of Src homology 2-containing-inositol 5-phosphatase (SHIP) in mast cells and macrophages. Biochem Soc Trans 2003; 31: 286-291.
19. Sly LM, Rauh MJ, Kalesnikoff J, Buchse T, Krystal G: SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in mac-rophages and mast cells by lipopolysaccha-ride. Exp Hematol 2003; 31: 1170-1181.
20. Huber M, Helgason CD, Damen JE, Liu L, Humphries RK, Krystal G: The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci USA 1998; 95: 11330-11335.
21. Vonakis BM, Gibbons S Jr, Sora R, Langdon JM, MacDonald SM: Src homology 2 domain-containing inositol 5-phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils. J Allergy Clin Immunol 2001; 108: 822-831.
22. Vonakis BM, Vasagar K, Gibbons SP Jr, Gober L, Sterba PM, Chang H, Saini SS: Ba-sophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria. J Allergy Clin Immunol 2007; 119: 441-448.
23. Gibbs BF, Rathling A, Zillikens D, Huber M, Haas H: Initial Fc epsilon RI-mediated signal strength plays a key role in regulating baso-phil signaling and deactivation. J Allergy Clin Immunol 2006; 118: 1060-1067.
24. Magro AM, Alexander A: Histamine release: studies of the inhibitory region of the dose-response curve. J Immunol 1974; 112: 1762-1764.
25. ++ responses in human basophils: evidence that the initial transient elevation associated with mobilization of intracellular calcium is an insufficient signal for degranulation. J Im-munol 1993; 150: 980-991.
26. Dembo M, Goldstein B, Sobotka AK, Lich-tenstein LM: Histamine release due to biva-lent penicilloyl haptens: control by the number of cross-linked IgE antibodies on the basophil plasma membrane. J Immunol 1978; 121: 354-358.
27. Dembo M, Goldstein B, Sobotka AK, Lich-tenstein LM: Histamine release due to biva-lent penicilloyl haptens: the relation of activation and desensitization of basophils to dynamic aspects of ligand binding to cell surface antibody. J Immunol 1979; 122: 518-528.
28. Damen JE, Liu L, Ware MD, Ermolaeva M, Majerus PW, Krystal G: Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation. Blood 1998; 92: 1199-1205.
29. Leung WH, Bolland S: The inositol 5′-phos-phatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol 2007; 179: 95-102.
30. Lavens-Phillips SE, Miura K, MacGlashan DW Jr: Pharmacology of IgE-mediated desensitization of human basophils: effects of protein kinase C and Src-family kinase inhibitors. Biochem Pharmacol 2000; 60: 1717-1727.
31. MacGlashan D, Miura K: Loss of syk kinase during IgE-mediated stimulation of human basophils. J Allergy Clin Immunol 2004; 114: 1317-1324.
32. Youssef LA, Wilson BS, Oliver JM: Protea-some-dependent regulation of Syk tyrosine kinase levels in human basophils. J Allergy Clin Immunol 2002; 110: 366-373.
33. Paolini R, Molfetta R, Beitz LO, Zhang J, Scharenberg AM, Piccoli M, Frati L, Siraga-nian R, Santoni A: Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiq-uitination of Fcepsilon RI and Syk in RBL cells. J Biol Chem 2002; 277: 36940-36947.
34. Kepley CL: Antigen-induced reduction in mast cell and basophil functional responses due to reduced Syk protein levels. Int Arch Allergy Immunol 2005; 138: 29-39.
35. MacGlashan DW Jr: Relationship between Syk and SHIP expression and secretion from human basophils in the general population. J Allergy Clin Immunol 2007; 119: 626-633.
36. Mendoza GR, Minagawa K: Subthreshold and suboptimal desensitization human ba-sophils. I. Kinetics of decay of releasability. Int Arch Allergy Appl Immunol 1982; 68: 101-107.
37. Pruzansky JJ, Patterson R: Desensitization of human basophils with suboptimal concentrations of agonist. Evidence for reversible and irreversible desensitization. Immunology 1988; 65: 443-447.
38. Komiya A, Hirai K, Iikura M, Nagase H, Yamada H, Miyamasu M, Ohta K, Morita Y, Ra C, Yamamoto K, Yamaguchi M: Induction of basophil desensitization in physiological medium: enhancement after IgE-dependent upregulation of surface IgE binding on basophils. Int Arch Allergy Immunol 2003; 130: 40-50.
39. Morales AR, Shah N, Castells M: Antigen-IgE desensitization in signal transducer and activator of transcription 6-deficient mast cells by suboptimal doses of antigen. Ann Allergy Asthma Immunol 2005; 94: 575-580.
40. Isersky C, Rivera J, Segal DM, Triche T: The fate of IgE bound to rat basophilic leukemia cells. II. Endocytosis of IgE oligomers and effect on receptor turnover. J Immunol 1983; 131: 388-396.
41. MacGlashan DW Jr, Mogowski M, Lichten-stein LM: Studies of antigen binding on human basophils. II. Continued expression of antigen-specific IgE during antigen-induced desensitization. J Immunol 1983; 130: 2337-2342.
42. MacGlashan DW Jr: Endocytosis, re-cycling and degradation of unoccupied FceRI in human basophils. J Leukoc Biol 2007; 82: 1003-1010.
43. Furuichi K, Rivera J, Triche T, Isersky C: The fate of IgE bound to rat basophilic leukemia cells. IV. Functional association between the receptors for IgE. J Immunol 1985; 134: 1766-1773.
44. MacGlashan DW Jr, Undem BJ: Inducing an anergic state in mast cells and basophils without secretion. J Allergy Clin Immunol 2008; 121: 1500-1506.
45. Furuichi K, Rivera J, Isersky C: The fate of IgE bound to rat basophilic leukemia cells. III. Relationship between antigen-induced endocytosis and serotonin release. J Immunol 1984; 133: 1513-1520.
46. Molfetta R, Belleudi F, Peruzzi G, Morrone S, Leone L, Dikic I, Piccoli M, Frati L, Torrisi MR, Santoni A, Paolini R: CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function. J Immunol 2005; 175: 4208-4216.
47. Pierini L, Harris NT, Holowka D, Baird B: Evidence supporting a role for microfilaments in regulating the coupling between poorly dissociable IgE-Fc epsilonRI aggregates downstream signaling pathways. Biochemistry 1997; 36: 7447-7456.
48. Field KA, Holowka D, Baird B: Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J Biol Chem 1997; 272: 4276-4280.
49. Holowka D, Gosse JA, Hammond AT, Han X, Sengupta P, Smith NL, Wagenknecht-Wies-ner A, Wu M, Young RM, Baird B: Lipid segregation and IgE receptor signaling: a decade of progress. Biochim Biophys Acta 2005; 1746: 252-259.
50. 2+ influx, phospholi-pase activation, and histamine release in rat basophilic leukemia cells. Int Arch Allergy Appl Immunol 1985; 78: 92-100.
51. Narasimhan V, Holowka D, Baird B: Micro-filaments regulate the rate of exocytosis in rat basophilic leukemia cells. Biochem Bio-phys Res Commun 1990; 171: 222-229.
52. Gillespie E, Lichtenstein LM: Histamine from human leukocytes: studies with deute-rium oxide, colchicine and cytochalasin B. J Clin Invest 1972; 51: 2941-2947.
53. Pfeiffer JR, Seagrave JC, Davis BH, Deanin GG, Oliver JM: Membrane and cytoskeletal changes associated with IgE-mediated sero-tonin release from rat basophilic leukemia cells. J Cell Biol 1985; 101: 2145-2155.
54. MacGlashan DW Jr, Vilarino N: Polymerization of actin does not regulate desensitization in human basophils. Submitted.
55. Seagrave JC, Deanin GG, Martin JC, Davis BH, Oliver JM: DNP-phycobiliproteins, fluorescent antigens to study dynamic properties of antigen-IgE-receptor complexes on RBL-2H3 rat mast cells. Cytometry 1987; 8: 287-295.
56. MacGlashan DW Jr, Lichtenstein LM: Studies of antigen binding on human basophils. I. Antigen binding and functional consequences. J Immunol 1983; 130: 2330-2336.
57. Goldstein B, Wofsy C: Why is it so hard to dissociate multivalent antigens from cell surface antibodies? Immunol Today 1996; 17: 77-80.
58. Itoh K, Sakakibara M, Yamasaki S, Takeuchi A, Arase H, Miyazaki M, Nakajima N, Oka-da M, Saito T: Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol 2002; 168: 541-544.
59. Vang T, Abrahamsen H, Myklebust S, Hore- jsi V, Tasken K: Combined spatial and enzymatic regulation of Csk by cAMP and pro- teinkinaseainhibitsTcellreceptorsignaling. J Biol Chem 2003; 278: 17597-17600.
60. Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA: Identification of the tyro-sine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 1995; 181: 2077-2084.
61. Ozawa T, Nakata K, Mizuno K, Yakura H: Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells. Int Immunol 2007; 19: 1049-1061.
62. Vilarino N, MacGlashan DW Jr: Actin cyto-skeleton-dependent down-regulation of early IgE-mediated signaling in human baso-phils. J Leukoc Biol 2004; 75: 928-937.
63. Rossi AB, Herlaar E, Braselmann S, Huynh S, Taylor V, Frances R, Issakani SD, Argade A, Singh R, Payan DG, Masuda ES: Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol 2006; 118: 749-755.
64. Vilarino N, MacGlashan D Jr: Transient transfection of human peripheral blood ba-sophils. J Immunol Methods 2005; 296: 11-18.
65. MacGlashan DW Jr, Ishmael S, Macdonald SM, Langdon JM, Arm JP, Sloane DE: Induced loss of Syk in human basophils by non-IgE-dependent stimuli. J Immunol 2008; 180: 4208-4217.