Review: Antenatal glucocorticoid treatment of the growth-restricted fetus: Benefit or cost?

Reproductive Sciences

Volumn 16, Issue 6, 2009, Pages 527-538

  Morrison, Janna L ^a   Orgeig, Sandra ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Antenatal glucocorticoids; Blood pressure; Intrauterine growth restriction; Preterm delivery; Surfactant

Indexed keywords

BETAMETHASONE; DEXAMETHASONE; GLUCOCORTICOID; LUNG SURFACTANT;

CARDIOVASCULAR FUNCTION; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DRUG EFFECT; FETUS; FETUS DEVELOPMENT; HEART DEVELOPMENT; HUMAN; INTRAUTERINE GROWTH RETARDATION; LUNG DEVELOPMENT; NONHUMAN; PRENATAL CARE; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; REVIEW; ANIMAL; ECONOMICS; FEMALE; FETUS WEIGHT; METHODOLOGY; NEWBORN; PERINATAL CARE; PHYSIOLOGY; PREGNANCY;

ANIMALS; COST-BENEFIT ANALYSIS; FEMALE; FETAL GROWTH RETARDATION; FETAL WEIGHT; GLUCOCORTICOIDS; HUMANS; INFANT, NEWBORN; PERINATAL CARE; PREGNANCY;

EID: 65549138475     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719109332821     Document Type: Review

References (103)

1. Laws PJ, Sullivan EA Australia's mothers and babies 2002. Perinat Stat Ser. 2004 (AIHW cat. no. PER 28): 1-93.
2. Antenatal corticosteroids revisited: repeat courses-National Institutes of Health Consensus Development Conference Statement, August 17-18, 2000. Obstet Gynecol. 2001 /7 2001 ; 98: 144-150. (Pubitemid 32622780)
3. Crowley PA Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol. 1995 ; 173: 322-335.
4. Elimian A., Verma U., Canterino J., Shah J., Visintainer P., Tejani N. Effectiveness of antenatal steroids in obstetric subgroups. Obstet Gynecol. 1999 ; 93: 174-179. (Pubitemid 29068087)
5. Bernstein IM, Horbar JD, Badger GJ, Ohlsson A., Golan A. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network. Am J Obstet Gynecol. 2000 ; 182 (1 pt 1). 198-206. (Pubitemid 30074392)
6. Schaap AH, Wolf H., Bruinse HW, Smolders-De Haas H., Van Ertbruggen I., Treffers PE Effects of antenatal corticosteroid administration on mortality and long-term morbidity in early preterm, growth-restricted infants. Obstet Gynecol. 2001 ; 97: 954-960. (Pubitemid 32522494)
7. National Institutes of Health Consensus Development. Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Statement ; February 28-March 2, 1994 ; 12: 1-24.
8. Modi N., Lewis H., Al-Naqeeb N., Ajayi-Obe M., Dore CJ, Rutherford M. The effects of repeated antenatal glucocorticoid therapy on the developing brain. Pediatr Res. 2001 ; 50: 581-585. (Pubitemid 33009981)
9. Brocklehurst P., Gates S., McKenzie-McHarg K., Alfirevic Z., Chamberlain G. Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK. BJOG. 1999 ; 106: 977-979. (Pubitemid 29415631)
10. Quinlivan JA, Evans SF, Dunlop SA, Beazley LD, Newnham JP Use of corticosteroids by Australian obstetricians-a survey of clinical practice. Aust N Z J Obstet Gynaecol. 1998 ; 38: 1-7. (Pubitemid 28077480)
11. Crowther CA, Haslam RR, Hiller JE, Doyle LW, Robinson JS Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet. 2006 ; 367: 1913-1919. (Pubitemid 43831995)
12. National Institutes of Health Consensus Development P. Antenatal Corticosteroids Revisited: Repeat Courses- National Institutes of Health Consensus Development Conference Statement, August 17-18, 2000. Obstet Gynecol. 2001 ; 98: 144-150. (Pubitemid 32622780)
13. Roberts D., Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006 ; 3: CD004454. (Pubitemid 46796994)
14. Crowther CA, Harding J. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst Rev. 2003: CD003935.
15. Morrison JL Sheep models of intrauterine growth restriction: fetal adaptations and consequences. Clin Exp Pharmacol Physiol. 2008 ; 35: 730-743.
16. McMillen IC, Adams MB, Ross JT, et al. Fetal growth restriction: adaptations and consequences. Reproduction. 2001 ; 122: 195-204. (Pubitemid 32737382)
17. Nathanielsz PW, Hanson MA The fetal dilemma: spare the brain and spoil the liver. J Physiol. 2003 ; 548 (pt 2). 333.
18. Dubiel M., Gunnarsson GO, Gudmundsson S. Blood redistribution in the fetal brain during chronic hypoxia. Ultrasound Obstet Gynecol. 2002 ; 20: 117-121. (Pubitemid 35300706)
19. Cheema R., Dubiel M., Gudmundsson S. Fetal brain sparing is strongly related to the degree of increased placental vascular impedance. J Perinat Med. 2006 ; 34: 318-322. (Pubitemid 44114571)
20. Schwab M., Roedel M., Anwar MA, et al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 ; 528 (pt 3). 619-632.
21. Spinillo A., Capuzzo E., Ometto A., Stronati M., Baltaro F., Iasci A. Value of antenatal corticosteroid therapy in preterm birth. Early Hum Dev. 1995 ; 42: 37-47.
22. Feldman DM, Carbone J., Belden L., Borgida AF, Herson V. Betamethasone vs dexamethasone for the prevention of morbidity in very-low-birthweight neonates. Am J Obstet Gynecol. 2007 ; 197: e281 - e284. (Pubitemid 47361987)
23. Jobe AH, Soll RF Choice and dose of corticosteroid for antenatal treatments. Am J Obstet Gynecol. 2004 ; 190: 878-881. (Pubitemid 38561501)
24. Nuyt AM Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models. Clin Sci. 2008 ; 114: 1-17.
25. Liggins GC Premature delivery of foetal lambs infused with glucocorticoids. Endocrinology. 1969 ; 45: 515-523.
26. Ikegami M., Polk D., Jobe A. Minimum interval from fetal betamethasone treatment to postnatal lung responses in preterm lambs. Am J Obstet Gynecol. 1996 ; 174: 1408-1413. (Pubitemid 26165253)
27. Jobe AH, Ikegami M. Lung development and function in preterm infants in the surfactant treatment era. Annu Rev Physiol. 2000 ; 62: 825-846. (Pubitemid 30618284)
28. Nyirenda MJ, Welberg LA, Seckl JR Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence ? J Endocrinol. 2001 ; 170: 653-660. (Pubitemid 32834332)
29. Dalziel SR, Walker NK, Parag V., et al. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet. 2005 ; 365: 1856-1862. (Pubitemid 40744963)
30. Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci. 2000 ; 98: 137-142. (Pubitemid 30105520)
31. Dalziel SR, Liang A., Parag V., Rodgers A., Harding JE Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial. Pediatrics. 2004 ; 114: e373 - e377. (Pubitemid 41529505)
32. Dalziel SR, Lim VK, Lambert A., et al. Antenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial. BMJ. 2005 ; 331: 665. (Pubitemid 41374841)
33. Dalziel SR, Rea HH, Walker NK, et al. Long term effects of antenatal betamethasone on lung function: 30 year follow up of a randomised controlled trial. Thorax. 2006 ; 61: 678-683. (Pubitemid 44211774)
34. Crowther CA, Doyle LW, Haslam RR, et al. Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med. 2007 ; 357: 1179-1189. (Pubitemid 47443177)
35. Moss TJM, Harding R., Newnham JP Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments. Early Hum Dev. 2002 ; 66: 11-24. (Pubitemid 34123284)
36. Walfisch A., Hallak M., Mazor M. Multiple courses of antenatal steroids: risks and benefits. Obstet Gynecol. 2001 ; 98: 491-497. (Pubitemid 32889587)
37. Huang WL, Harper CG, Evans SF, Newnham JP, Dunlop SA Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep. Int J Dev Neurosci. 2001 ; 19: 415-425. (Pubitemid 32500337)
38. Sloboda DM, Newnham JP, Challis JR Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term. J Endocrinol. 2000 ; 165: 79-91. (Pubitemid 30210568)
39. Sloboda DM, Newnham JP, Challis JR Repeated maternal glucocorticoid administration and the developing liver in fetal sheep. J Endocrinol. 2002 ; 175: 535-543. (Pubitemid 35414399)
40. Baud O., Sola A. Corticosteroids in perinatal medicine: how to improve outcomes without affecting the developing brain ? Sem Fetal Neonat Med. 2007 ; 12: 273-279. (Pubitemid 46875062)
41. Banks BA, Cnaan A., Morgan MA, et al. Multiple courses of antenatal corticosteroids and outcome of premature neonates. Am J Obstet Gynecol. 1999 ; 181: 709-717. (Pubitemid 29453537)
42. Vermillion ST, Soper DE, Chasedunn-Roark J. Neonatal sepsis after betamethasone administration to patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 1999 ; 181: 320-325. (Pubitemid 29409907)
43. Vermillion ST, Soper DE, Newman RB Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy. Am J Obstet Gynecol. 2000 ; 183: 810-814.
44. Helal KJ, Gordon MC, Lightner CR, Barth WH Adrenal suppression induced by betamethasone in women at risk for premature delivery. Obstet Gynecol. 2000 ; 96: 287-290. (Pubitemid 30447355)
45. McKenna DS, Wittber GM, Nagaraja HN, Samuels P. The effects of repeat doses of antenatal corticosteroids on maternal adrenal function. Am J Obstet Gynecol. 2000 ; 183: 669-673.
46. Fisher JE, Smith RS, Lagrandeur R., Lorenz RP Gestational diabetes mellitus in women receiving beta-adrenergics and corticosteroids for threatened preterm delivery. Obstet Gynecol. 1997 ; 90: 880-883. (Pubitemid 27510121)
47. Abbasi S., Hirsch D., Davis J., et al. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol. 2000 ; 182: 1243-1249. (Pubitemid 30353319)
48. McEvoy C., Bowling S., Williamson K., et al. The effect of a single remote course versus weekly courses of antenatal corticosteroids on functional residual capacity in preterm infants: a randomized trial. Pediatrics. 2002 ; 110: 280-284.
49. Schwab M., Coksaygan T., Nathanielsz PW Betamethasone effects on ovine uterine and umbilical placental perfusion at the dose used to enhance fetal lung maturation. Am J Obstet Gynecol. 2006 ; 194: 572-579. (Pubitemid 43183718)
50. Huang WL, Beazley LD, Quinlivan JA, Evans SF, Newnham JP, Dunlop SA Effect of corticosteroids on brain growth in fetal sheep. Obstet Gynecol. 1999 ; 94: 213-218. (Pubitemid 29352864)
51. Anwar MA, Schwab M., Poston L., Nathanielsz PW Betamethasone-mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am J Physiol. 1999 ; 276 (4 pt 2). H1137 - H1143. (Pubitemid 29214125)
52. Fletcher AJ, McGarrigle HH, Edwards CM, Fowden AL, Giussani DA Effects of low dose dexamethasone treatment on basal cardiovascular and endocrine function in fetal sheep during late gestation. J Physiol. 2002 ; 545 (pt 2). 649-660. (Pubitemid 36004394)
53. Bennet L., Kozuma S., McGarrigle HH, Hanson MA Temporal changes in fetal cardiovascular, behavioural, metabolic and endocrine responses to maternally administered dexamethasone in the late gestation fetal sheep. BJOG. 1999 ; 106: 331-339. (Pubitemid 29150256)
54. Tangalakis K., Lumbers ER, Moritz KM, Towstoless MK, Wintour EM Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol. 1992 ; 77: 709-717.
55. Forhead AJ, Broughton Pipkin F., Fowden AL Effect of cortisol on blood pressure and the renin-angiotensin system in fetal sheep during late gestation. J Physiol. 2000 ; 526 (pt 1). 167-176. (Pubitemid 30456099)
56. Forhead AJ, Fowden AL Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestation. Exp Physiol. 2004 ; 89: 323-329. (Pubitemid 38660046)
57. Derks JB, Giussani DA, Jenkins SL, et al. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol. 1997 ; 499 (pt 1). 217-226. (Pubitemid 27096097)
58. Polglase GR, Nitsos I., Jobe AH, Newnham JP, Moss TJ Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs. Pediatr Res. 2007 ; 62: 32-36. (Pubitemid 46985846)
59. Ueda T., Ikegami M., Polk D., Mizuno K., Jobe A. Effects of fetal corticosteroid treatments on postnatal surfactant function in preterm lambs. J Appl Physiol. 1995 ; 79: 846-851. (Pubitemid 26045387)
60. Ballard PL, Ning Y., Polk D., Ikegami M., Jobe AH Glucocorticoid regulation of surfactant components in immature lambs. Am J Physiol. 1997 ; 17: L1048 - L1057. (Pubitemid 27508354)
61. Bunton TE, Plopper CG Triamcinolone-induced structural alterations in the development of the lung of the fetal rhesus macaque. Am J Obstet Gynecol. 1984 ; 148: 203-215. (Pubitemid 14224259)
62. Willet KE, Jobe AH, Ikegami M., Kovar J., Sly PD Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep. Am J Respir Crit Care Med. 2001 ; 163: 1437-1443. (Pubitemid 32506613)
63. Tan RC, Ikegami M., Jobe AH, Yao LY, Possmayer F., Ballard PL Developmental and glucocorticoid regulation of surfactant protein mRNAs in preterm lambs. Am J Physiol. 1999 ; 277 (6 pt 1). L1142 - L1148. (Pubitemid 30046041)
64. Jobe AH Glucocorticoids, inflammation and the perinatal lung. Sem Neonat. 2001 ; 6: 331-342. (Pubitemid 34586852)
65. Newnham JP, Evans SF, Godfrey M., Huang W., Ikegami M., Jobe A. Maternal, but not fetal, administration of corticosteroids restricts fetal growth. J Matern Fetal Med. 1999 ; 8: 81-87. (Pubitemid 29218463)
66. Newnham JP, Moss TJ Antenatal glucocorticoids and growth: single versus multiple doses in animal and human studies. Semin Neonatol. 2001 ; 6: 285-292. (Pubitemid 34586848)
67. Jobe AH, Moss TJ, Nitsos I., Ikegami M., Kallapur SG, Newnham JP Betamethasone for lung maturation: testing dose and formulation in fetal sheep. Am J Obstet Gynecol. 2007 ; 197: e521 - e526. (Pubitemid 350007383)
68. Jobe AH, Wada N., Berry LM, Ikegami M., Ervin MG Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. Am J Obstet Gynecol. 1998 ; 178: 880-885. (Pubitemid 28247157)
69. Alexander G. Studies on the placenta of the sheep (Ovis aries L.). Effect of surgical reduction in the number of caruncles. J Reprod Fertil. 1964 ; 30: 307-322.
70. Regnault TR, Friedman JE, Wilkening RB, Anthony RV, Hay WW Jr. Fetoplacental transport and utilization of amino acids in IUGR-a review. Placenta. 2005 ; 26 (suppl A). S52 - S62.
71. Walker DW, Davies AN, McMillen IC Effect of hyperthermia on the plasma concentrations of prolactin and cortisol in the fetal lamb and pregnant ewe during late gestation. J Dev Physiol. 1990 ; 13: 173-177. (Pubitemid 20362672)
72. Miller SL, Chai M., Loose J., et al. The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology. 2007 ; 148: 1288-1295. (Pubitemid 46272827)
73. Supramaniam VG, Jenkin G., Loose J., Wallace EM, Miller SL Chronic fetal hypoxia increases activin A concentrations in the late-pregnant sheep. BJOG. 2006 ; 113: 102-109.
74. Wallace JM, Aitken RP, Milne JS, Hay WW Jr. Nutritionally mediated placental growth restriction in the growing adolescent: consequences for the fetus. Biol Reprod. 2004 ; 71: 1055-1062. (Pubitemid 39249787)
75. Wallace JM, Milne JS, Aitken RP Maternal growth hormone treatment from day 35 to 80 of gestation alters nutrient partitioning in favor of uteroplacental growth in the overnourished adolescent sheep. Biol Reprod. 2004 ; 70: 1277-1285. (Pubitemid 38509673)
76. Robinson JS, Kingston EJ, Jones CT, Thornburn GD Studies on experimental growth retardation in sheep. The effect of removal of endometrial caruncles on fetal size and metabolism. J Dev Physiol. 1979 ; 1: 379-398. (Pubitemid 10064332)
77. Morrison JL, Botting KJ, Dyer JL, Williams SJ, Thornburg KL, McMillen IC Restriction of placental function alters heart development in the sheep fetus. Am J Physiol Regul Integr Comp Physiol. 2007 ; 293: R306 - R313.
78. Danielson L., McMillen IC, Dyer JL, Morrison JL Restriction of placental growth results in greater hypotensive response to alpha-adrenergic blockade in fetal sheep during late gestation. J Physiol. 2005 ; 563 (pt 2). 611-620. (Pubitemid 40360917)
79. Robinson JS, Owens JA, Owens PC Fetal growth and fetal growth retardation. In: Thorburn GD, Harding R, eds. Textbook of Fetal Physiology. Oxford: Oxford University Press; 1994: 83-94.
80. Edwards LJ, Simonetta G., Owens JA, Robinson JS, McMillen IC Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril. J Physiol. 1999 ; 515 (pt 3). 897-904. (Pubitemid 29140122)
81. McMillen IC, Robinson JS Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005 ; 85: 571-633. (Pubitemid 40404637)
82. Economides DL, Nicolaides KH, Linton EA, Perry LA, Chard T. Plasma cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses. Fetal Ther. 1988 ; 3: 158-164. (Pubitemid 19251193)
83. Economides DL, Nicolaides KH, Campbell S. Metabolic and endocrine findings in appropriate and small for gestational age fetuses. J Perinat Med. 1991 ; 19: 97-105.
84. Simonetta G., Rourke AK, Owens JA, Robinson JS, McMillen IC Impact of placental restriction on the development of the sympathoadrenal system. Pediatr Res. 1997 ; 42: 805-811. (Pubitemid 27509540)
85. Phillips ID, Simonetta G., Owens JA, Robinson JS, Clarke IJ, McMillen IC Placental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation. Pediatr Res. 1996 ; 40: 861-866. (Pubitemid 26404197)
86. Mildenhall LF, Battin MR, Morton SM, Bevan C., Kuschel CA, Harding JE Exposure to repeat doses of antenatal glucocorticoids is associated with altered cardiovascular status after birth. Arch Dis Child Fetal Neonatal Ed. 2006 ; 91: F56 - F60. (Pubitemid 43059204)
87. Lipsett J., Tamblyn M., Madigan K., et al. Restricted fetal growth and lung development: a morphometric analysis of pulmonary structure. Pediatr Pulmonol. 2006 ; 41: 1138-1145.
88. Lechner AJ Perinatal age determines the severity of retarded lung development induced by starvation. Am Rev Respir Dis. 1985 ; 131: 638-643. (Pubitemid 15086755)
89. Chen CM, Wang LF, Su B. Effects of maternal undernutrition during late gestation on the lung surfactant system and morphometry in rats. Pediatr Res. 2004 ; 56: 329-335. (Pubitemid 39128815)
90. Gross TL, Sokol RJ, Wilson MV, Kuhnert PM, Hirsch V. Amniotic fluid phosphatidylglycerol: a potentially useful predictor of intrauterine growth retardation. Am J Obstet Gynecol. 1981 ; 140: 277-281. (Pubitemid 11078546)
91. Tyson JE, Kennedy K., Broyles S., Rosenfeld CR The small for gestational age infant: accelerated or delayed pulmonary maturation? Increased or decreased survival? Pediatrics. 1995 ; 95: 534-538.
92. Torrance HL, Mulder EJ, Brouwers HA, van Bel F., Visser GH Respiratory outcome in preterm small for gestational age fetuses with or without abnormal umbilical artery Doppler and/or maternal hypertension. J Matern Fetal Neonatal Med. 2007 ; 20: 613-621. (Pubitemid 47221561)
93. Rees S., Ng J., Dickson K., Nicholas T., Harding R. Growth retardation and the development of the respiratory system in fetal sheep. Early Hum Dev. 1991 ; 26: 13-27.
94. Lechner AJ, Winston DC, Bauman JE Lung mechanics, cellularity, and surfactant after prenatal starvation in guinea pigs. J Appl Physiol. 1986 ; 60: 1610-1614. (Pubitemid 16088050)
95. Lin Y., Lechner AJ Surfactant content and type II cell development in fetal guinea pig lungs during prenatal starvation. Pediatr Res. 1991 ; 29: 288-291.
96. Braems GA, Yao LJ, Inchley K., et al. Ovine surfactant protein cDNAs: use in studies on fetal lung growth and maturation after prolonged hypoxemia. Am J Physiol. 2000 ; 278: L754 - L764. (Pubitemid 30220037)
97. Gagnon R., Langridge J., Inchley K., Murotsuki J., Possmayer F. Changes in surfactant-associated protein mRNA profile in growth-restricted fetal sheep. Am J Physiol. 1999 ; 276 (3 pt 1). L459 - L465. (Pubitemid 29159535)
98. Cock ML, Albuquerque CA, Joyce BJ, Hooper SB, Harding R. Effects of intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep. Am J Obstet Gynecol. 2001 ; 184: 209-216. (Pubitemid 32141667)
99. Nardo L., Hooper SB, Harding R. Lung hypoplasia can be reversed by short-term obstruction of the trachea in fetal sheep. Pediatr Res. 1995 ; 38: 690-696.
100. Orgeig S., Daniels CB Effects of aging, disease and the environment on the pulmonary surfactant system. In: Harding R, Pinkerton K, Plopper C, eds. The Lung: Development, Aging and the Environment. London: Academic Press; 2004: 363-375.
101. Orgeig S., Daniels CB, Sullivan LC Development of the pulmonary surfactant system. In: Harding R, Pinkerton K, Plopper C, eds. The Lung: Development, Aging and the Environment. London: Academic Press; 2004: 149-167.
102. Polyakov A., Cohen S., Baum M., Trickey D., Jolley D., Wallace EM Patterns of antenatal corticosteroid prescribing 1998-2004. Aust N Z J Obstet Gynaecol. 2007 ; 47: 42-45. (Pubitemid 46152469)
103. Laws PJ, Hilder L. Australia's Mothers and Babies 2006. Sydney: Australian Institute of Health & Welfare ; 2006 (no. 22, Cat. no. PER 46).