Sex steroid hormones influence the risk for cervical cancer: modulation by haptoglobin genetic polymorphism

Cancer Genetics and Cytogenetics

Volumn 191, Issue 2, 2009, Pages 85-89

  Bicho, Maria Clara ^a   Pereira da Silva, Alda ^b   Matos, Ana ^c   Silva, Rui Medeiros ^c   Bicho, Manuel Diamantino ^b  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; SEX HORMONE;

ADULT; AGED; ALLELE; ARTICLE; CANCER INVASION; CANCER RISK; CARCINOGENESIS; DRUG USE; FEMALE; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC RISK; HETEROZYGOTE; HORMONAL THERAPY; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; UTERINE CERVIX CANCER; UTERINE CERVIX DYSPLASIA;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; AGING; CARCINOMA, SQUAMOUS CELL; CONTRACEPTIVES, ORAL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HAPTOGLOBINS; HETEROZYGOTE DETECTION; HUMANS; MIDDLE AGED; NEOPLASM INVASIVENESS; PHENOTYPE; POLYMORPHISM, GENETIC; PORTUGAL; RISK FACTORS; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 65549134687     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.02.005     Document Type: Article

References (28)

1. Munoz N., Bosch F.X., de Sanjose S., Herrero R., Castellsague X., and Shah K.V. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348 (2003) 518-527
2. Castellsagué X., Bosch F.X., and Muñoz N. Environmental co-factors in HPV carcinogenesis. Virus Res 89 (2002) 191-199
3. Villiers E.M. Relationship between steroid hormone contraceptives and HPV, cervical intraepithelial neoplasia and cervical carcinoma. Int J Cancer 103 (2003) 705-708
4. Elson D.A., Riley R.R., Lacey A., Thordarson G., Talamantes F.J., and Arbeit J.M. Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis. Cancer Res 60 (2000) 1267-1275
5. Paavonen T., Andersson L.C., and Adlercreutz H. Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures. J Exp Med 154 (1981) 1935-1945
6. Hughes G.C., and Clark E.A. Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity. Autoimmunity 40 (2007) 470-481
7. Sharpe-Timms K.L., Zimmer R.L., Ricke E.A., Piva M., and Horowitz G.M. Endometriotic haptoglobin binds to peritoneal macrophages and alters their function in women with endometriosis. Fertil Steril 78 (2002) 810-818
8. Shaw J.L.V., Smith C.R., and Diamands P. Proteomic analysis of women cervico-vaginal fluid. J Proteom Res 6 (2007) 2859-2865
9. Langlois M.R., and Delanghe J.R. Biological and clinical significance of haptoglobin in human. Clin Chem 42 (1996) 1589-1600
10. Vlierberghe H.V., and Langlois M. Delanghe. Haptoglobin polymorphisms and iron homeostasis in health and in disease. Clinica Chimica Acta 345 (2004) 35-42
11. Quaye I.K. Haptoglobin, inflammation and disease. Trans R Soc Trop Med Hyg 102 (2008) 735-742
12. Guetta J., Strauss M., Levy N.S., Fahoum L., and Levy A.P. Haptoglobin genotype modulates the balance of Th1/th2 cytokines produced by macrophages exposed to free haemoglobin. Atherosclerosis 191 (2007) 48-53
13. Bottini N., Gimelfarb A., Gloria-Bottini F., Torre M.L., Lucarelli P., and Lucarini N. Haptoglobin genotype and natural fertility in humans. Fertil Steril 72 (1999) 293-296
14. El Ghmati S.M., Van Hoeyveld E.M., Van Strijp J.G., Ceuppens J.L., and Stevens E.A. Identification of haptoglobin as an alternative ligand for CD11b/CD18. J Immunol 156 (1996) 2542-2552
15. Matos A., Moutinho J., Pinto D., and Medeiros R. The influence of smoking and other cofactors on the time to onset to cervical cancer in a southern European population. Europ J Cancer Prevent 14 (2005) 485-491
16. Guerra A., Monteiro C., Breitenfeld L., Jardim H., Rego C., Silva D., Prata A., Matos J., Pereira A., and Santos N.T. BichoM. Genetic and environmental factors regulating blood pressure in childhood: prospective study from 0 to 3 years. J Hum Hypertens 11 (1997) 233-238
17. Clerici M., Shearer G.M., and Clerici E. Cytokine dysregulation in invasive cervical carcinoma and other human neoplasias: Time to consider the TH1/TH2 paradigm. J Natl Cancer Inst 90 (1998) 261-263
18. Mahmud S.M., Koushik A., Duarte E., Costa J., Fontes G., Bicho M., Coutlée F., and Franco E. Haptoglobin phenotype and risk of cervical neoplasia: a case-control study. Clinica Chimica Acta 385 (2007) 67-72
19. Larkin M. Serum Haptobglobin type and cancer. J Natl Cancer Inst 39 (1967) 633-638
20. Milunicova A., Jandova A., and Skoda A. Serum haptoglobin type in females with genital cancer. J Natl Cancer Inst 42 (1969) 749-751
21. Bartel U., Eling D., and Gesserick G. Distribution of Hp fenoptypes in gyneclogic tumors. Zentralbl Gynakol 107 (1985) 1492-1495
22. Lacey J.V., Brinton L.A., Abbas F.M., Barnes W.A., Gravitt P.E., and Greenberg M.D. Oral contraceptives as risk factors for cervical adenocarcinomas and squamous cell carcinomas. Cancer Epidemiol Biomark Prev 8 (1999) 1079-1085
23. Brabin L. Interactions of the female hormonal environment, susceptibility to viral infections, and disease progression. AIDS Patient Care STDS 16 (2002) 211-221
24. Nair H.B., Luthra R., Kirma N., Liu Y.G., Flowers L., Evans D., and Tekmal R.R. Induction of aromatase expression in cervical carcinomas: effects of endogenous estrogen on cervical cancer cell proliferation. Cancer Res 65 (2005) 11164-11173
25. Webster K., Taylor A., and Gaston K. Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7. J Gen Virology 82 (2001) 201-213
26. Jernström H., Klug T.L., Sepkovic D.W., Bradlow H.L., and Narod A.S. Predictors of the plasma ratio of 2-hydroxyestrone to 16α-hydroxyestrone among pre-menopausal, nulliparous women from four ethnic groups. Carcinogenesis 24 (2003) 991-1005
27. Talmedge J.E. Pathways mediating the expansion and immunossupressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy. Clin Cancer Res 13 (2007) 5243-5248
28. Nunes F, Rodrigues R, Avillez T, Breitenfeld L, Bicho M, Meirinho M. Biochemical markers for cervical ripening. Monduzzi editore- Medimond Inc.: Proceedings of the 5th World Congress of Perinatal Medicine 2001;614-620.