Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 5, 2009, Pages 2185-2193

  Calera, Mónica R ^a,b   Wang, Zhao ^c   Sanchez Olea, Roberto ^a,b   Paul, David L ^d   Civan, Mortimer M ^c   Goodenough, Daniel A ^a  

^a Department of Cell Biology ^*  (United States)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; CRE RECOMBINASE; TRANSCRIPTION FACTOR PAX6; BETA GALACTOSIDASE; EYE PROTEIN; HOMEODOMAIN PROTEIN; INTEGRASE; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR FLOW; ARTICLE; CILIARY BODY EPITHELIUM; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS BREEDING; ELECTRON MICROSCOPY; GAP JUNCTION; GENE INACTIVATION; INTRAOCULAR PRESSURE; IRIS; MICROPIPETTE; MOUSE; NONHUMAN; NONPIGMENT EPITHELIUM; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; CELL JUNCTION; CILIARY BODY; CYTOCHEMISTRY; EPITHELIUM; IN SITU HYBRIDIZATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

ANIMALS; BETA-GALACTOSIDASE; CILIARY BODY; CONNEXIN 43; EPITHELIUM; EYE PROTEINS; GAP JUNCTIONS; HISTOCYTOCHEMISTRY; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; INTEGRASES; INTRAOCULAR PRESSURE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PAIRED BOX TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS;

EID: 65549126824     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2962     Document Type: Article

References (35)

1. Cole DF. Secretion of the aqueous humor. Exp Eye Res. 1977; 25(suppl):161-176.
2. Raviola G, Raviola E. Intercellular junctions in the ciliary epithelium. Invest Ophthalmol Vis Sci. 1978;17(10):958-981.
3. Civan MM, Macknight ADC. The ins and outs of aqueous humor secretion. Exp Eye Res. 2004;78(3):625-631.
4. Veenstra RD, Wang H-Z, Beblo DA, et al. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res. 1995;77(6):1156-1165.
5. Sáez JC, Berthoud VM, Brañes MC, Martínez AD, Beyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev. 2003;83(4):1359-1400.
6. Goldberg GS, Valiunas V, Brink PR. Selective permeability of gap junction channels. Biochim Biophys Acta. 2004;1662(1-2):96-101.
7. Sohl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res. 2004;62(2):228-232.
8. Severs NJ. The cardiac gap junction and intercalated disc. Int J Cardiol. 1990;26(2):137-173.
9. Dermietzel R, Hertberg EL, Kessler JA, Spray DC. Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis. J Neurosci. 1991;11(5):1421-1432.
10. Dermietzel R, Spray DC. Gap junctions in the brain: where, what type, how many and why? Trends Neurosci. 1993;16(5):186-192.
11. Rozental R, Srinivas M, Gokhan S, et al. Temporal expression of neuronal connexins during hippocampal ontogeny. Brain Res Brain Res Rev. 2000;32(1):57-71.
12. Iino S, Asamoto K, Nojyo Y. Heterogeneous distribution of a gap junction protein, connexin43, in the gastroduodenal junction of the guinea pig. Auton Neurosci. 2001;93(1-2):8-13.
13. Loddenkemper T, Grote K, Evers S, Oelerich M, Stogbauer F. Neurological manifestations of the oculodentodigital dysplasia syndrome. J Neurol. 2002;249(5):584-595.
14. Paznekas WA, Boyadjiev SA, Shapiro RE, et al. Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Am J Hum Genet. 2003;72(2):408-418.
15. Debeer P, Van Esch H, Huysmans C, et al. Novel GJA1 mutations in patients with oculodento-digital dysplasoa (ODDD). Eur J Med Genet. 2005;48(4):377-387.
16. Vasconcellos JP, Melo MB, Schimitl RB, Bressanim NC, Costa FF, Costa VP. A novel mutation in the GJA1 gene in a family with oculodentodigital dysplasia. Arch Ophthalmol. 2005;123(10): 1422-1426.
17. Flenniken AM, Osborne LR, Anderson N, et al. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005;132(19):4375-4386.
18. White TW, Sellitto C, Paul DL, Goodenough DA. Prenatal lens development in connexin43 and connexin50 double knockout mice. Invest Ophthalmol Vis Sci. 2001;42(12):2916-2923.
19. Reaume AG, De Sousa PA, Kulkarni S, et al. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267(5205): 1831-1834.
20. Cottrell GT, Burt JM. Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons. Am J Physiol Cell Physiol. 2001;281(5):C1559-C1567.
21. Kammandel B, Chowdhury K, Stoykova A, Aparicio S, Brenner S, Gruss P. Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol. 1999;205(1):79-97.
22. Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, Gruss P. Pax6 is required for the multipotent state of retinal progenitor cells. Cell. 2001;105(1):43-55.
23. Liao Y, Day KH, Damon DN, Duling BR. Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc Natl Acad Sci U S A. 2001;98(17):9989-9994.
24. Irwin MH, Moffatt RJ, Pinkert CA. Identification of transgenic mice by PCR analysis of saliva. Nat Biotechnol. 1996;14(9):1146-1148.
25. Schilling K, Dickinson MH, Connor JA, Morgan JI. Electrical activity in cerebellar cultures determines Purkinje cell dendritic growth patterns. Neuron. 1991;7(6):891-902.
26. Jiang JX, White TW, Goodenough DA. Changes in connexin expression and distribution during chick lens development. Dev Biol. 1995;168(2):649-661.
27. Montmayeur JP, Liberles SD, Matsunami, Buck LB. A candidate taste receptor gene near a sweet taste locus. Nat Neurosci. 2001; 4(5):492-498.
28. Wang Z, Do CW, Avila MY, Stone RA, Jacobson KA, Civan MM. Barrier qualities of the mouse eye to topically applied drugs. Exp Eye Res. 2007;85(1):105-112.
29. Ashery-Padan R, Marquardt T, Zhou X, Gruss P. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000;14(21): 2701-2711.
30. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999;21(1):70-71.
31. Paul DL, Goodenough DA. Preparation, characterization and localization of antisera against bovine MP26, an integral protein from lens fiber plasma membrane. J Cell Biol. 1983;96(3):625-632.
32. Civan MM. Transport by the ciliary epithelium of the eye. News Physiol Sci. 1997;12(4):158-162.
33. Macknight ADC, McLaughlin CW, Peart D, Purves RD, Carre DA, Civan MM. Formation of the aqueous humor. Clin Exp Pharmacol Physiol. 2000;27(1-2):100-106.
34. Kimura K, Suzuki T, Sagara T, Nishida T, Yamamoto Y, Kitazawa Y. Regulation of connexin phosphorylation and cell-cell coupling in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2000;41(8): 2222-2228.
35. Johnson R, Hammer M, Sheridan J, Revel JP. Gap junction formation between reaggregated Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974;71(11):4536-4540.