Pulmonary retention of actinides after dissolution of PuO2 aerosols: Interest in modelling DTPA decorporation

Radioprotection

Volumn 43, Issue 2, 2008, Pages 239-253

  Serandour A L ^a   Fritsch, P ^a  

^a DIF   (France)

Author keywords

Bound fraction; Dissolution parameters; DTPA; Modelling; PuO2 aerosols

Indexed keywords

ALVEOLAR MACROPHAGES; BOUND FRACTION; CHELATING AGENT; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; DTPA; INHALATION EXPOSURE; INTERNAL CONTAMINATIONS; PULMONARY ADMINISTRATIONS;

AEROSOLS; ANTIGEN-ANTIBODY REACTIONS; BIOASSAY; BIOLOGICAL ORGANS; CHELATION; DISSOLUTION; MACROPHAGES; MODELS; RATS;

ACTINIDES;

EID: 65549120514     PISSN: 00338451     EISSN: 1769700X     Source Type: Journal    
DOI: 10.1051/radiopro:2008004     Document Type: Article

References (27)

1. André S., Charuau J., Rateau G., Vavasseur C., Métivier H. (1989) Design of a new inhalation device for rodents and primates, J. Aerosol. Sci. 6, 647-656.
2. Birchall A., Bailey M.R., Jarvis N.S. (1995) Application of the new ICRP respiratory tract model to inhaled plutonium nitrate using experimental biokinetic data. In: Proceedings of the international conference on radiation dose management in the nuclear industry, Windermere, UK, 9-11 October, 1995. pp. 216-223. British Nuclear Energy Society.
3. Cooper J.R., Stradling G.N. Smith H., Breadmore S.E. (1979) The reactions of 1.0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid, Int. J. Radiat. Biol. 36, 453-466.
4. Diel J.H., Mewhninney J.A. (1983) Fragmentation of inhaled 238PuO2 particles in lung, Health Phys. 44, 135-143.
5. Fleischer R.L., Raabe O.G. (1977) Fragmentation of respirable PuO2 in water by alpha decay: a mode of "dissolution", Health Phys. 32, 253-257.
6. Fritsch P. (2007) The distribution of the number of alpha hits per target cell: a new parameter to improve risk assessment for cancer induction using ICRP models, Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm466.
7. Fritsch P., Dudoignon N., Guillet K., Oghiso Y., Morlier J.P., Monchaux G. (2003) Does mean lung dose calculated after inhalation of alpha emitters actually reflect the risk of induction of malignant lung tumour? Radiat. Prot. Dosim. 105, 149-152.
8. Fritsch P., Grappin L., Guillermin A.M., Fottorino R., Ruffin M., Miele A. (2007) Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches. Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm260.
9. Gervelas C., Sérandour A.L., Geiger S., Grillon G., Fritsch P., Taulelle C., Le Gall B., Benech H., Deverre J.R., Fattal E., Tsapis N. (2007) Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: Effect on lung and systemic decorporation of plutonium, J. Control. Release 118, 78-86.
10. Hahn F.F., Romanov S.A., Guilmette R.A., Nifatov A.P., Zaytseva Y.V., Diel J.H., Allen, S.W., Lyovkina, Y.V. (2003) Distribution of plutonium particles in the lungs of Mayak workers, Radiat. Prot. Dosim. 105, 81-84.
11. Guilmette R.A., Muggenburg B.A. (1988) Reducing the radiation dose from inhaled americium-241 using continuously administered DTPA therapy, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 53, 261-271.
12. Guilmette R.A., Griffith W.C., Hickman A.W. (1994) Intake assessment for workers who have inhaled 238Pu aerosols. Radiat. Prot. Dosim. 53, 127-131.
13. ICRP Publication 30 (1979) Limits of intakes of radionuclides by workers, Ann. ICRP 2(3-4).
14. ICRP Publication 66 (1994) Human respiratory tract model for radiological protection, Ann. ICRP 24(1-3).
15. ICRP Supporting guidance 3 (2002) Guide for the practical application of the ICRP human respiratory tract model, Oxford: Pergamon Press, 32.
16. James A.C., Sasser L.B., Stuit D.B., Glover S.E., Carbaugh E.H. (2007) USTUR whole body case 0269: demonstrating effectiveness of I.V. Ca-DTPA for Pu, Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm473.
17. Lataillade G., Verry M., Rateau G., Métivier H., Masse R. (1995) Translocation of plutonium from rat and monkey lung after inhalation of industrial plutonium oxide and mixed uranium and plutonium oxide, Int. J. Radiat. Biol. 67, 373-380.
18. Métivier H. (1997) Plutonium, "Toxiques nuclé aires", P. Galle (Ed.). Masson, Paris, pp. 225-245.
19. Métivier H., Masse R., Rateau G., Lafuma J. (1980) Experimental study of respiratory contamination by a mixed oxide aerosol formed from the combustion of a plutonium magnesium alloy, Health Phys. 38, 769-776.
20. Ramounet B., Matton S., Guezingar-Liebard F., Abram M.C., Rateau G., Grillon G., Fritsch P. (2000) Comparative biokinetics of plutonium and americium after inhalation of PuO2 and mixed oxides (U, Pu)O2 in rat, Int. J. Radiat. Biol. 76, 215-222.
21. Rateau-Matton S., Ansoborlo E., Hodgson A. (2004) Comparative absorption parameters of Pu and Am from PuO2 and mixed oxide aerosols measured after in vitro dissolution test and inhalation in rats, Int. J. Radiat. Biol. 80, 777-785.
22. Sato H., Bulman R.A., Takahashi S., Kubota Y. (1994) Effects of macromolecular chelating agents on the release of 239Pu and 59Fe from alveolar macrophages after phagocytic uptake of 239Pu-59Feiron hydroxide colloid, Health Phys. 66, 545-549.
23. Sérandour A.L., Tsapis N., Gervelas C., Grillon G., Frechou M., Deverre J.R., Benech H., Fattal E., Fritsch P., Poncy J.L. (2007) Decorporation of plutonium by pulmonary administration of Ca-DTPA dry powder: a study in rat after lung contamination with different plutonium forms, Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm300.
24. Stather J.W., Stradling G.N., Smith H., Payne S., James A.C., Strong J.C., Ham S., Sumner S., Bulman R.A., Hodgson A., Towndrow C., Ellender M. (1982) Decorporation of 238PuO2 from the hamster by inhalation of chelating agents, Health Phys. 42, 520-525.
25. Stradling G.N., Loveless B.W., Ham G.J., Smith H. (1978a) The biological solubility in the rat of plutonium present in mixed plutonium-sodium aerosols, Health Phys. 35, 229-235.
26. Stradling G.N., Ham G.J., Smith H., Cooper J., Breadmore S.E. (1978b) Factors affecting the mobility of plutonium-238 dioxide in the rat, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 34, 37-47.
27. Stradling G.N., Stather J.W., Sumner S.A., Strong J.C., Lennox A.M., Ham S.E. (1984) Decorporation of inhaled plutonium nitrate from hamsters using Zn-DTPA, Health Phys. 46, 919-924.