Optimization of the near-infrared fluorescence labeling for in vivo monitoring of a protein drug distribution in animal model

Journal of Fluorescence

Volumn 19, Issue 2, 2009, Pages 277-284

  Qian, Huimin ^a,c   Gu, Yueqing ^a   Wang, Min ^a   Achilefu, Samuel ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Fluorescence dye; In vivo optical imaging; Labeling condition; Near infrared; Protein drugs

Indexed keywords

ANIMAL MODEL; BLOOD SERUM; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DYNAMIC DISTRIBUTION; ENZYMATIC ACTIVITIES; FEED RATIOS; FLUORESCENT DYES; IN VIVO OPTICAL IMAGING; IN-VIVO; L-ASPARAGINASE; NEAR INFRARED; NEAR-INFRARED FLUORESCENCE; NIR IMAGE; OPTIMAL CONDITIONS; PH CONDITION; PH VALUE; PROTEIN CONJUGATES; PROTEIN DRUGS; PROTEIN LABELING; SMALL ANIMAL;

ANIMALS; CATALYSIS; FLUORESCENCE; INFRARED DEVICES; OPTICAL IMAGE STORAGE; OPTIMIZATION; PH; THERMAL EFFECTS;

LABELS;

ANIMALIA;

ASPARAGINASE; DRUG; FLUORESCENT DYE; PROTEIN;

ANIMAL; ANIMAL MODEL; ARTICLE; CATALYSIS; CHEMISTRY; DIAGNOSTIC IMAGING; DRUG STABILITY; GENETIC PROCEDURES; MOUSE; PH; TEMPERATURE; TISSUE DISTRIBUTION;

ANIMALS; ASPARAGINASE; CATALYSIS; DIAGNOSTIC IMAGING; DRUG STABILITY; FLUORESCENT DYES; HYDROGEN-ION CONCENTRATION; MICE; MODELS, ANIMAL; MOLECULAR PROBE TECHNIQUES; PHARMACEUTICAL PREPARATIONS; PROTEINS; TEMPERATURE; TISSUE DISTRIBUTION;

EID: 65549119685     PISSN: 10530509     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10895-008-0413-3     Document Type: Article

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