Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Taniguchi, Koji ^a,b,c   Sasaki, Ken Ichiro ^d   Watari, Kousuke ^a   Yasukawa, Hideo ^d   Imaizumi, Tsutomu ^d   Ayada, Toranoshin ^a   Okamoto, Fuyuki ^a   Ishizaki, Takuma ^c   Kato, Reiko ^a   Kohno, Ri Ichiro ^a   Kimura, Hiroshi ^e   Sato, Yasufumi ^e   Ono, Mayumi ^a   Yonemitsu, Yoshikazu ^a,f   Yoshimura, Akihiko ^c,g  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT HAIRPIN RNA; SPROUTY 2 PROTEIN; SPROUTY 4 PROTEIN; SPROUTY PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; NERVE PROTEIN; SMALL INTERFERING RNA; SPRY2 PROTEIN, MOUSE; SPRY4 PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; FEMALE; GENE TARGETING; ISCHEMIA; KNOCKOUT MOUSE; LIMB ISCHEMIA; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PERIPHERAL ISCHEMIA; REGULATORY MECHANISM; ANIMAL; BLOOD VESSEL; CORNEA; DISEASE MODEL; HINDLIMB; LYMPH VESSEL; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; VASCULARIZATION;

MUS;

ANIMALS; BLOOD VESSELS; CORNEA; DISEASE MODELS, ANIMAL; HINDLIMB; ISCHEMIA; LYMPHATIC VESSELS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; RNA, SMALL INTERFERING;

EID: 65549111249     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005467     Document Type: Article

References (40)

1. Kim HJ, Bar-Sagi D (2004) Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol 5: 441-450.
2. Mason JM, Morrison DJ, Basson MA, Licht JD (2006) Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol 16: 45-54.
3. Cabrita MA, Christofori G (2008) Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis 11: 53-62.
4. Takahashi T, Yamaguchi S, Chida K, Shibuya M (2001) A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. Embo J 20: 2768-2778.
5. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (1998) sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92: 253-263.
6. Casci T, Vinos J, Freeman M (1999) Sprouty, an intracellular inhibitor of Ras signaling. Cell 96: 655-665.
7. Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, et al. (2001) Spred is a Sprouty-related suppressor of Ras signalling. Nature 412: 647-651.
8. Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, et al. (2003) Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Biochem Biophys Res Commun 302: 767-772.
9. Brems H, Chmara M, Sahbatou M, Denayer E, Taniguchi K, et al. (2007) Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. Nat Genet 39: 1120-1126.
10. Flamme I, Frolich T, Risau W (1997) Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J Cell Physiol 173: 206-210.
11. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-31.
12. Hanahan D (1997) Signaling vascular morphogenesis and maintenance. Science 277: 48-50.
13. Shibuya M (2008) Vascular endothelial growth factor-dependent and - independent regulation of angiogenesis. BMB Rep 41: 278-286.
14. Hannun YA, Obeid LM (2008) Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 9: 139-150.
15. Impagnatiello MA, Weitzer S, Gannon G, Compagni A, Cotten M, et al. (2001) Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. J Cell Biol 152: 1087-1098.
16. Lee SH, Schloss DJ, Jarvis L, Krasnow MA, Swain JL (2001) Inhibition of angiogenesis by a mouse sprouty protein. J Biol Chem 276: 4128-4133.
17. Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, et al. (2003) Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol 5: 427-432.
18. Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, et al. (2007) Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol 27: 4541-4550.
19. Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, et al. (2009) Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis. Oncogene 28: 1076-1088.
20. Sasaki A, Taketomi T, Wakioka T, Kato R, Yoshimura A (2001) Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. J Biol Chem 276: 36804-36808.
21. Taniguchi K, Ayada T, Ichiyama K, Kohno R, Yonemitsu Y, et al. (2007) Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. Biochem Biophys Res Commun 352: 896-902.
22. D'Amato R, Wesolowski E, Smith LE (1993) Microscopic visualization of the retina by angiography with high-molecular-weight fluorescein-labeled dextrans in the mouse. Microvasc Res 46: 135-142.
23. Sasaki K, Heeschen C, Aicher A, Ziebart T, Honold J, et al. (2006) Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci U S A 103: 14537-14541.
24. Tepper OM, Capla JM, Galiano RD, Ceradini DJ, Callaghan MJ, et al. (2005) Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood 105: 1068-1077.
25. Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, et al. (2005) Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci 8: 855-857.
26. Sivak JM, Petersen LF, Amaya E (2005) FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation. Dev Cell 8: 689-701.
27. Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, et al. (2008) The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15: 261-271.
28. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, et al. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15: 272-284.
29. Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, et al. (2008) Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 135: 3989-3993.
30. Schalch P, Patejunas G, Retuerto M, Sarateanu S, Milbrandt J, et al. (2004) Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: evidence for a central role in vascular homeostasis. J Thorac Cardiovasc Surg 128: 595-601.
31. Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, et al. (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2. Circ Res 90: 966-973.
32. Sugano M, Tsuchida K, Maeda T, Makino N (2007) SiRNA targeting SHP-1 accelerates angiogenesis in a rat model of hindlimb ischemia. Atherosclerosis 191: 33-39.
33. Antoine M, Wirz W, Tag CG, Mavituna M, Emans N, et al. (2005) Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. Growth Factors 23: 87-95.
34. Takeshita S, Isshiki T, Sato T (1996) Increased expression of direct gene transfer into skeletal muscles observed after acute ischemic injury in rats. Lab Invest 74: 1061-1065.
35. Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, et al. (2007) An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. Int Immunol 19: 609-619.
36. Morisada T, Oike Y, Yamada Y, Urano T, Akao M, et al. (2005) Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood 105: 4649-4656.
37. Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, et al. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454: 656-660.
38. Chavakis E, Aicher A, Heeschen C, Sasaki K, Kaiser R, et al. (2005) Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med 201: 63-72.
39. Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, et al. (2009) Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood, in press.
40. Nakao S, Kuwano T, Tsutsumi-Miyahara C, Ueda S, Kimura YN, et al. (2005) Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. J Clin Invest 115: 2979-2991.