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Volumn 324, Issue 5927, 2009, Pages 659-662

A yeast hybrid provides insight into the evolution of gene expression regulation

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL DNA; GLYCEROL;

EID: 65549086559     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1169766     Document Type: Article
Times cited : (321)

References (21)
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    • Alternatively, it is possible that some of these allele-specific expression changes reflect epigenetic effects in the hybrid, although this possibility appears unlikely because cytosine methylation has not been found in budding yeast and the observed allele-specific changes are not clustered at specific chromosomal domains [as might be expected for epigenetic effects (fig. S6)].
    • Alternatively, it is possible that some of these allele-specific expression changes reflect epigenetic effects in the hybrid, although this possibility appears unlikely because cytosine methylation has not been found in budding yeast and the observed allele-specific changes are not clustered at specific chromosomal domains [as might be expected for epigenetic effects (fig. S6)].
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    • Materials and methods are available as supporting material on Science Online.
    • Materials and methods are available as supporting material on Science Online.
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    • We thank J. Berman, Y. Eshed, N. Sigal, A. Sheperberg, and members of our groups for discussions and comments. This work was supported by the Helen and Martin Kimmel Award for Innovative Investigations and grants from the Kahn Fund for Systems Biology at the Weizmann Institute of Science, the Israeli Ministry of Science, the Bi-national Science Foundation, and the European Research Council Ideas, to N.B, A.A.L. holds the Gilbert de Botton chair of Plant Science. Microarray data has been deposited at the Gene Expression Omnibus with accession number GSE14708
    • We thank J. Berman, Y. Eshed, N. Sigal, A. Sheperberg, and members of our groups for discussions and comments. This work was supported by the Helen and Martin Kimmel Award for Innovative Investigations and grants from the Kahn Fund for Systems Biology at the Weizmann Institute of Science, the Israeli Ministry of Science, the Bi-national Science Foundation, and the European Research Council (Ideas) (to N.B). A.A.L. holds the Gilbert de Botton chair of Plant Science. Microarray data has been deposited at the Gene Expression Omnibus with accession number GSE14708.


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