Mechanism of CB1954 reduction by Escherichia coli nitroreductase

Biochemical Society Transactions

Volumn 37, Issue 2, 2009, Pages 413-418

  Christofferson, Andrew ^a   Wilkie, John ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

5 aziridin 1 yl 2,4 dinitrobenzamide (C81954); Cancer treatment; Electron transfer; Escherichia coli nitroreductase; Hydride transfer; Virus directed enzyme prodrug therapy (VDEPT)

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; AROMATIC NITRO COMPOUND; DNA; FLAVOPROTEIN; NITROREDUCTASE; PROTON; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; 5-(1-AZIRIDINYL)-2,4-DINITROBENZAMIDE; AZIRIDINE DERIVATIVE; ESCHERICHIA COLI PROTEIN; NFNB PROTEIN, E COLI; PRODRUG;

ARTICLE; CANCER GENE THERAPY; CELL DEATH; CYTOTOXICITY; DNA CROSS LINKING; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE DIRECTED ENZYME PRODRUG THERAPY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; REDUCTION; WILD TYPE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; OXIDATION REDUCTION REACTION; REVIEW;

ESCHERICHIA COLI;

AZIRIDINES; CATALYTIC DOMAIN; COMPUTER SIMULATION; ESCHERICHIA COLI PROTEINS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NITROREDUCTASES; OXIDATION-REDUCTION; PRODRUGS;

EID: 65549085223     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0370413     Document Type: Article

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