Adaptive optics for deeper imaging of biological samples

Current Opinion in Biotechnology

Volumn 20, Issue 1, 2009, Pages 106-110

  Girkin, John M ^a   Poland, Simon ^b   Wright, Amanda J ^b  

^a DURHAM UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPENSATIONS; BIOLOGICAL SAMPLES; LIFE SCIENCE; NON-LINEAR MICROSCOPIES; OPTICAL ELEMENTS; OPTIMAL ALIGNMENTS; REAL TIME; SUBCELLULAR RESOLUTIONS; SUBMICRON RESOLUTIONS; THREE-DIMENSIONAL IMAGES; WIDE FIELDS;

OPTICAL DEVICES; OPTICAL INSTRUMENTS; OPTICAL PROPERTIES; THREE DIMENSIONAL;

OPTICAL MICROSCOPY;

IMAGE QUALITY; MICROSCOPY; MULTIPHOTON MICROSCOPY; OPTICAL RESOLUTION; PRIORITY JOURNAL; REVIEW;

DIAGNOSTIC IMAGING; MICROSCOPY; MODELS, THEORETICAL; OPTICAL DEVICES;

EID: 65449171687     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2009.02.009     Document Type: Review

References (34)

1. Tyson R.K. Principles of Adaptive Optics (1997), Academic Press
2. Hell S., Reiner G., Cremer C., and Stelzer E.H.K. Aberrations in confocal fluorescence microscope induced by mismatches in refractive index. J Microsc 169 (1993) 391-405
3. Sheppard C.J.R., Connolly T.J., Lee J., and Cogswell C.J. Confocal imaging of a stratified medium. Appl Opt 33 (1994) 631-640
4. Sheppard C.J.R., Min G., Brain K., and Zhou H. Influence of spherical aberration on axial imaging of confocal reflection microscopy. Appl Opt 33 (1994) 616-624
5. Schwertner M., Booth M.J., and Wilson T. Characterizing specimen induced aberrations for high NA adaptive optical microscopy. Opt Exp 12 (2004) 6540-6552. A study of several different tissue types demonstrating the aberrations that samples can introduce into the imaging system.
6. Schwertner M., Booth M.J., Neil M.A.A., and Wilson T. Measurement of specimen-induced aberrations of biological samples using phase stepping interferometry. J Microsc 213 (2004) 11-19
7. Salomatina E., and Yaroslavsky A.N. Evaluation of the in vivo and ex vivo optical properties in a mouse ear model. Phys Med Biol 53 (2008) 2797-9807
8. Hovhannisyan V.A., Su P.-J., and Dong C.Y. Characterization of optical-aberration-induced lateral and axial image inhomogeneity in multiphoton microscopy. J Biomed Opt 13 (2008) 044023.6-144023.6
9. Pawley J.B. Fundamental limits in confocal microscopy. In: Pawley J.B. (Ed). Handbook of Biological Confocal Microscopy (2006), Springer 20-41
10. Girkin J.M., and Marsh P.N. Use of adaptive optics for enhanced multiphoton microscopy. Proc SPIE Int Soc Opt Eng 5323 (2004) 260-269
11. Theer P., and Denk W. On the fundamental imaging-depth limit in two-photon microscopy. J Opt Soc Am A 23 (2006) 3139-3149. This paper discusses the various contributions to depth limitations in two-photon imaging indicating that fluorescence from scattered light outside the focal plan places a limitation on the depth of imaging but increasing the objective lens NA and labeling inhomogeneity will help increase the imaging depth.
12. Neil M.A.A., Juskaitis R., and Wilson T. Method of obtaining optical sectioning by using structured light in a conventional microscope. Opt Lett 22 (1997) 1905-1907
13. Sherman L., Ye J.Y., Albert O., and Norris T.B. Adaptive correction of depth-induced aberrations in multiphoton scanning microscopy using a deformable Mirror. J Microsc 206 (2002) 65-71. The first reported use of adaptive optics in multiphoton microscopy.
14. Booth M.J., Neil M.A.A., Juskaitis R., and Wilson T. Adaptive aberration correction in a confocal microscope. Proc Natl Acad Sci U S A 99 (2002) 5788-5792. The first reported use of adaptive optics in confocal microscopy.
15. Marsh P.N., Burns D., and Girkin J.M. Practical implementation of adaptive optics in multiphoton microscopy. Opt Exp 11 (2003) 1123-1130. This paper provides an excellent practical way to implement active correction in multiphoton microscopy for the first time in a beam-scanned system.
16. Vdovin G., Soloviev O., Samokhin A., and Loktev M. Correction of low order aberrations using continuous deformable mirrors. Opt Exp 16 (2008) 2859-2866
17. Bonora S., Capraro I., Poletto L., Romanin M., Trestino C., and Villoresi P. Wave front active control by a digital-signal-processor-driven deformable membrane mirror. Rev Sci Instrum 77 (2006) 093102.5-193102.5.
18. Vuelban E.M., Bhattacharya N., and Braat J.J.M. Liquid deformable mirror for high-order wavefront correction. Opt Lett 31 (2006) 1717-1719
19. Tsai P.S., Migliori B., Campbell K., Kim T.N., Kam Z., Groisman A., and Kleinfeld D. Spherical aberration correction in nonlinear microscopy and optical ablation using a transparent deformable membrane. Appl Phys Lett 91 (2007) 191102.3-1191102.3.
20. Mu Q., Cao Z., Hu L., Li D., and Xuan L. Adaptive optics imaging system based on a high resolution liquid crystal on silicon device. Opt Exp 14 (2006) 8013-8018
21. Schmidt J.D., Goda M.E., and Duncan B.D. Aberration production using a high-resolution liquid-crystal spatial light modulator. Appl Opt 46 (2007) 2423-2433
22. Wright A.J., Patterson B.A., Poland S., Girkin J.M., Gibson G., and Padgett M.J. A dynamic closed loop system for focus tracking using a spatial light modulator and a deformable membrane mirror. Opt Exp 14 (2006) 222-228
23. Neil M.A.A., Jusïtkaitis R., Booth M.J., Wilson T., Tanaka T., and Kawata S. Adaptive aberration correction in a two-photon microscope. J Microsc 200 (2000) 105-108
24. Debarre D., Booth M.J., and Wilson T. Image based adaptive optics through optimisation of low spatial frequencies. Opt Exp 15 (2007) 8176-8190
25. Wright A.J., Burns D., Patterson B.A., Poland S., Valentine, and Girkin J.M. Optimisation algorithms for the implementation of adaptive optics in confocal and multiphoton microscopy. Microsc Res Tech 67 (2005) 36-42
26. Poland S.P., Wright A.J., and Girkin J.M. Evaluation of fitness parameters used in an iterative approach to aberration correction in optical sectioning microscopy. Appl Opt 47 (2008) 731-736
27. Booth M.J. Wave front sensor-less adaptive optics: a model-based approach using sphere packings. Opt Exp 14 (2006) 1339-1352
28. Wright A.J., Poland S.P., Girkin J.M., Freudiger C.W., Evans C.L., and Xie X.S. Adaptive optics for enhanced signal in CARS microscopy. Opt Exp 15 (2007) 18209-18216. This paper demonstrates the use of the technology for other nonlinear microscopic methods and illustrates the importance of the use of 'look-up' tables for practical implementation in a real biological setting.
29. Girkin J.M., Vijverberg J., Orazio M., Poland S., and Wright A.J. Adaptive optics in confocal and two-photon microscopy of rat brain: a single correction per optical section. Proc SPIE Multiphoton Microsc Biomed Sci VII 6462 (2007) 4420.6-14420.6.
30. Potsaid B., Bellouard Y., and Wen J.T. Adaptive scanning optical microscope (ASOM): a multidisciplinary optical microscope design for large field of view and high resolution imaging. Opt Exp 13 (2005) 6504-6518. Application of adaptive optics in a widefield microscope.
31. Kner P., Sedat J., Agard D., and Kam Z. Applying adaptive optics to three-dimensional wide-field microscopy. Proc SPIE 6888 (2008) 8-20
32. Debarre D., Botcherby E.J., Booth M.J., and Wilson T. Adaptive optics for structured illumination microscopy. Opt Exp 16 (2008) 9290-9305. This study demonstrates the application in structured light imaging and the real advances that can be made in resolution.
33. Leray A., and Mertz J. Rejection of two-photon fluorescence background in thick tissue by differential aberration imaging. Opt Exp 14 (2006) 10565-10573. A way to overcome the stated limitations of nonlinear microscopy at depth through the rejection of out of focus generated fluorescence.
34. Poland S.P., Wright A.J., and Girkin J.M. Active focus-locking in an optically sectioning microscope utilizing a deformable membrane mirror. Opt Lett 33 (2008) 419-421