The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by γδ T cells

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Page, Nicolas ^a   Schall, Nicolas ^a   Strub, Jean Marc ^b   Quinternet, Marc ^c   Chaloin, Olivier ^a   Décossas, Marion ^a   Cung, Manh Thong ^c   Van Dorsselaer, Alain ^b   Briand, Jean Paul ^a   Muller, Sylviane ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c LAB DE CHIM PHYS MACROMOLECULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; HEAT SHOCK COGNATE PROTEIN 70; IMMUNOMODULATING AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHOPEPTIDE; PROTEIN P140; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT; SMALL NUCLEAR RIBONUCLEOPROTEIN; SPLICEOSOMAL PEPTIDE P140;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE CONTROL; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SPLICEOSOME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CHEMISTRY; DOWN REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; METABOLISM; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; REGULATORY T LYMPHOCYTE; SURFACE PLASMON RESONANCE; T LYMPHOCYTE;

MUS;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BINDING SITES; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; HSC70 HEAT-SHOCK PROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED MRL LPR; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; SURFACE PLASMON RESONANCE; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 65449168745     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005273     Document Type: Article

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