Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: A role for Panton-Valentine leukocidin?

Infection and Immunity

Volumn 77, Issue 5, 2009, Pages 2159-2167

  Montgomery, Christopher P ^a   Daum, Robert S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; PANTON VALENTINE LEUKOCIDIN; BACTERIAL TOXIN; EXOTOXIN; LEUKOCIDIN; PANTON-VALENTINE LEUKOCIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL SURVIVAL; BACTERIUM ISOLATE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; IMMUNE RESPONSE; INOCULATION; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NECROTIZING PNEUMONIA; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RAT; STAPHYLOCOCCUS INFECTION; ANIMAL; BACTERIAL COUNT; BACTERIAL PNEUMONIA; BIOSYNTHESIS; COMMUNICABLE DISEASE; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; LUNG; MICROBIOLOGY; PATHOLOGY; SURVIVAL;

ANIMALS; BACTERIAL TOXINS; COLONY COUNT, MICROBIAL; COMMUNITY-ACQUIRED INFECTIONS; CYTOKINES; EXOTOXINS; GENE DELETION; GENE EXPRESSION PROFILING; LEUKOCIDINS; LUNG; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PNEUMONIA, BACTERIAL; RATS; STAPHYLOCOCCAL INFECTIONS; SURVIVAL ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 65449166473     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00021-09     Document Type: Article

References (23)

1. Adem, P. V., C. P. Montgomery, A. N. Husain, T. K. Koogler, V. Arangelovich, M. Humilier, S. Boyle-Vavra, and R. S. Daum. 2005. Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. N. Engl. J. Med. 353:1245-1251.
2. Bartlett, A. H., T. J. Foster, A. Hayashida, and P. W. Park. 2008. Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia. J. Infect. Dis. 198:1529-1535.
3. Boyle-Vavra, S., and R. S. Daum. 2007. Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin. Lab Invest. 87:3-9.
4. Bubeck Wardenburg, J., T. Bae, M. Otto, F. R. Deleo, and O. Schneewind. 2007. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat. Med. 13:1405-1406.
5. Bubeck Wardenburg, J., A. M. Palazzolo-Ballance, M. Otto, O. Schneewind, and F. R. DeLeo. 2008. Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J. Infect. Dis. 198:1166-1170.
6. Diep, B. A., A. M. Palazzolo-Ballance, P. Tattevin, L. Basuino, K. R. Braughton, A. R. Whitney, L. Chen, B. N. Kreiswirth, M. Otto, F. R. DeLeo, and H. F. Chambers. 2008. Contribution of Panton-Valentine leukocidin in community- associated methicillin-resistant Staphylococcus aureus pathogenesis. PLoS ONE 3:e3198.
7. Gillet, Y., B. Issartel, P. Vanhems, J. C. Fournet, G. Lina, M. Bes, F. Vandenesch, Y. Piemont, N. Brousse, D. Floret, and J. Etienne. 2002. Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 359:753-759.
8. Gresham, H. D., J. H. Lowrance, T. E. Caver, B. S. Wilson, A. L. Cheung, and F. P. Lindberg. 2000. Survival of Staphylococcus aureus inside neutrophils contributes to infection. J. Immunol. 164:3713-3722.
9. Kielian, T., B. Barry, and W. F. Hickey. 2001. CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses. J. Immunol. 166:4634-4643. (Pubitemid 32233750)
10. Klevens, R. M., M. A. Morrison, J. Nadle, S. Petit, K. Gershman, S. Ray, L. H. Harrison, R. Lynfield, G. Dumyati, J. M. Townes, A. S. Craig, E. R. Zell, G. E. Fosheim, L. K. McDougal, R. B. Carey, and S. K. Fridkin. 2007. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:1763-1771.
11. Labandeira-Rey, M., F. Couzon, S. Boisset, E. L. Brown, M. Bes, Y. Benito, E. M. Barbu, V. Vazquez, M. Hook, J. Etienne, F. Vandenesch, and M. G. Bowden. 2007. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 315:1130-1133.
12. McLoughlin, R. M., J. C. Lee, D. L. Kasper, and A. O. Tzianabos. 2008. IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J. Immunol. 181:1323-1332.
13. + T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc. Natl. Acad. Sci. USA 103:10408-10413.
14. Miller, L. S., R. M. O'Connell, M. A. Gutierrez, E. M. Pietras, A. Shahangian, C. E. Gross, A. Thirumala, A. L. Cheung, G. Cheng, and R. L. Modlin. 2006. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24:79-91. (Pubitemid 43077202)
15. Miller, L. S., E. M. Pietras, L. H. Uricchio, K. Hirano, S. Rao, H. Lin, R. M. O'Connell, Y. Iwakura, A. L. Cheung, G. Cheng, and R. L. Modlin. 2007. Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J. Immunol. 179:6933-6942.
16. + T cells play a critical role in experimental empyema. J. Infect. Dis. 181:1693-1699.
17. Montgomery, C. P., S. Boyle-Vavra, P. V. Adem, J. C. Lee, A. N. Husain, J. Clasen, and R. S. Daum. 2008. Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J. Infect. Dis. 198:561-570.
18. Prevost, G., P. Couppie, P. Prevost, S. Gayet, P. Petiau, B. Cribier, H. Monteil, and Y. Piemont. 1995. Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins. J. Med. Microbiol. 42:237-245.
19. Robertson, C. M., E. E. Perrone, K. W. McConnell, W. M. Dunne, B. Boody, T. Brahmbhatt, M. J. Diacovo, N. Van Rooijen, L. A. Hogue, C. L. Cannon, T. G. Buchman, R. S. Hotchkiss, and C. M. Coopersmith. 2008. Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J. Surg. Res. 150:278-285.
20. Small, C. L., S. McCormick, N. Gill, K. Kugathasan, M. Santosuosso, N. Donaldson, D. E. Heinrichs, A. Ashkar, and Z. Xing. 2008. NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung. J. Immunol. 180:5558-5568.
21. Ventura, C. L., R. Higdon, L. Hohmann, D. Martin, E. Kolker, H. D. Liggitt, S. J. Skerrett, and C. E. Rubens. 2008. Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia. Infect. Immun. 76:5862-5872.
22. Verdrengh, M., and A. Tarkowski. 1997. Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus. Infect. Immun. 65:2517-2521.
23. Voyich, J. M., M. Otto, B. Mathema, K. R. Braughton, A. R. Whitney, D. Welty, R. D. Long, D. W. Dorward, D. J. Gardner, G. Lina, B. N. Kreiswirth, and F. R. DeLeo. 2006. Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J. Infect. Dis. 194:1761-1770.