2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2777-2779

  Duan, Hongliang ^a   Zheng, Jin ^b   Lai, Qinglin ^a   Liu, Zheng ^b   Tian, Guanghui ^a   Wang, Zhen ^a   Li, Jianfeng ^a   Shen, Jingshan ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Topharman Shanghai Co Ltd   (China)

Author keywords

2 Phenylquinazolin 4(3H) one; Erectile dysfunction; PDE5 Inhibitor; Selectivity versus PDE6; Sildenafil

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; QUINAZOLINE DERIVATIVE; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; ERECTILE DYSFUNCTION; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; ERECTILE DYSFUNCTION; MALE; PHOSPHODIESTERASE INHIBITORS; QUINAZOLINONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65449165278     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.125     Document Type: Article

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