A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5′UTR located within intron 11

BMC Molecular Biology

Volumn 10, Issue , 2009, Pages

  Welham, Simon J M ^a   Clark, Adrian J L ^b   Salter, Andrew M ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE COMMON ANTIGEN RELATED RECEPTOR; LUCIFERASE; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; PROTEIN LAR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ISOPROTEIN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EXON; GENE AMPLIFICATION; INTRON; LIVER; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; WESTERN BLOTTING; ANIMAL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE ALIGNMENT;

RATTUS;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTRONS; LIVER; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; RATS; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; SEQUENCE ALIGNMENT;

EID: 65449143882     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-10-30     Document Type: Article

References (33)

1. Streuli M Krueger NX Thai T Tang M Saito H Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR EMBO J 1990, 9(8):2399-2407. 552264 1695146
2. Tsujikawa K Kawakami N Uchino Y Ichijo T Furukawa T Saito H Yamamoto H Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor Mol Endocrinol 2001, 15(2):271-280. 10.1210/me.15.2.271 11158333
3. Zhang JS Longo FM LAR tyrosine phosphatase receptor: Alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats J Cell Biol 1995, 128(3):415-431. 2120354 7844155 10.1083/jcb.128.3.415
4. Zhang JS Honkaniemi J Yang T Yeo TT Longo FM LAR tyrosine phosphatase receptor: A developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific Mol Cell Neurosci 1998, 10(5-6):271-286. 10.1006/mcne.1998.0663
5. Yang T Yin W Derevyanny VD Moore LA Longo FM Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth Eur J Neurosci 2005, 22(9):2159-2170. 10.1111/ j.1460-9568.2005.04403.x 16262654
6. Xie Y Massa SM Ensslen-Craig SE Major DL Yang T Tisi MA Derevyanny VD Runge WO Mehta BP Moore LA et al Protein-tyrosine phosphatase (PTP) wedge domain peptides: A novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function J Biol Chem 2006, 281(24):16482-16492. 10.1074/jbc.M603131200 16613844
7. Yang T Massa SM Longo FM LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways J Neurobiol 2006, 66(13):1420-1436. 10.1002/neu.20291 17013927
8. Ahmad F Goldstein BJ Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells J Biol Chem 1997, 272(1):448-457. 10.1074/jbc.272.11.7519 8995282
9. Mooney RA Anderson DL Phosphorylation of the insulin receptor in permeabilized adipocytes is coupled to a rapid dephosphorylation reaction J Biol Chem 1989, 264(12):6850-6857. 2468661
10. Zhang WR Li PM Oswald MA Goldstein BJ Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR Mol Endocrinol 1996, 10(5):575-584. 10.1210/me.10.5.575 8732688
11. Hashimoto N Feener EP Zhang WR Goldstein BJ Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain J Biol Chem 1992, 267(20):13811-13814. 1321126
12. Kulas DT Zhang WR Goldstein BJ Furlanetto RW Mooney RA Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR J Biol Chem 1995, 270(6):2435-2438. 10.1074/ jbc.270.6.2435 7852302
13. Kulas DT Goldstein BJ Mooney RA The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases J Biol Chem 1996, 271(2):748-754. 10.1074/jbc.271.2.748 8557682
14. Mooney RA Kulas DT Bleyle LA Novak JS The protein tyrosine phosphatase LAR has a major impact on insulin receptor dephosphorylation Biochem Biophys Res Commun 1997, 235(3):709-712. 10.1006/bbrc.1997.6889 9207225
15. Petry CJ Dorling MW Pawlak DB Ozanne SE Hales CN Diabetes in old male offspring of rat dams fed a reduced protein diet Int J Exp Diabetes Res 2001, 2(2):139-143. 2478537 12369717 10.1155/EDR.2001.139
16. Streuli M Krueger NX Ariniello PD Tang M Munro JM Blattler WA Adler DA Disteche CM Saito H Expression of the receptor-linked protein tyrosine phosphatase LAR: Proteolytic cleavage and shedding of the CAM-like extracellular region EMBO J 1992, 11(3):897-907. 556530 1547787
17. Haapasalo A Kim DY Carey BW Turunen MK Pettingell WH Kovacs DM Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin J Biol Chem 2007, 282(12):9063-9072. 10.1074/ jbc.M611324200 17259169
18. Stoker AW Protein tyrosine phosphatases and signalling J Endocrinol 2005, 185(1):19-33. 10.1677/joe.1.06069 15817824
19. Niu XL Li J Hakim ZS Rojas M Runge MS Madamanchi NR Leukocyte antigen-related deficiency enhances insulin-like growth factor-1 signaling in vascular smooth muscle cells and promotes neointima formation in response to vascular injury J Biol Chem 2007, 282(27):19808-19819. 10.1074/jbc.M610452200 17500057
20. Zabolotny JM Kim YB Peroni OD Kim JK Pani MA Boss O Klaman LD Kamatkar S Shulman GI Kahn BB et al Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance Proc Natl Acad Sci USA 2001, 98(9):5187-5192. 33185 11309481 10.1073/pnas.071050398
21. Ahmad F Azevedo JL Cortright R Dohm GL Goldstein BJ Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes J Clin Invest 1997, 100(2):449-458. 508209 9218523 10.1172/JCI119552
22. Mander A Hodgkinson CP Sale GJ Knock-down of LAR protein tyrosine phosphatase induces insulin resistance FEBS Lett 2005, 579(14):3024-3028. 10.1016/j.febslet.2005.04.057 15896785
23. Ren JM Li PM Zhang WR Sweet LJ Cline G Shulman GI Livingston JN Goldstein BJ Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis Diabetes 1998, 47(3):493-497. 10.2337/diabetes.47.3.493 9519761
24. Shimano H Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes Prog Lipid Res 2001, 40(6):439-452. 10.1016/S0163-7827(01)00010-8 11591434
25. Duncan BK Miller JH Mutagenic deamination of cytosine residues in DNA Nature 1980, 287(5782):560-561. 10.1038/287560a0 6999365
26. Sved J Bird A The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model Proc Natl Acad Sci USA 1990, 87(12):4692-4696. 54183 2352943 10.1073/pnas.87.12.4692
27. Kozak M Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes Cell 1986, 44(2):283-292. 10.1016/0092-8674(86)90762-2 3943125
28. Kozak M An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs Nucleic Acids Res 1987, 15(20):8125-8148. 306349 3313277 10.1093/nar/15.20.8125
29. Bendtsen JD Nielsen H von Heijne G Brunak S Improved prediction of signal peptides: SignalP 3.0 J Mol Biol 2004, 340(4):783-795. 10.1016/ j.jmb.2004.05.028 15223320
30. Nielsen H Engelbrecht J Brunak S von Heijne G Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Protein Eng 1997, 10(1):1-6. 10.1093/protein/10.1.1 9051728
31. Yang T Bernabeu R Xie Y Zhang JS Massa SM Rempel HC Longo FM Leukocyte antigen-related protein tyrosine phosphatase receptor: A small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth J Neurosci 2003, 23(8):3353-3363. 12716943
32. Majeti R Weiss A Regulatory mechanisms for receptor protein tyrosine phosphatases Chem Rev 2001, 101(8):2441-2448. 10.1021/cr000085m 11749382
33. O'Grady P Thai TC Saito H The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR J Cell Biol 1998, 141(7):1675-1684. 2133008 9647658 10.1083/jcb.141.7.1675