Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents

Journal of Smooth Muscle Research

Volumn 44, Issue 6, 2008, Pages 195-207

  Ojewole, John A O ^a   Awe, Emmanuel O ^a   Chiwororo, Witness D H ^a  

^a University of KwaZulu Natal Faculty of Health Sciences   (South Africa)

Author keywords

Antidiarrhoeal activity; Leaf aqueous extract; Psidium guajava

Indexed keywords

ANTIDIARRHEAL AGENT; ATROPINE; CASTOR OIL; LOPERAMIDE; PLANT EXTRACT;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; DIARRHEA; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; FEMALE; GASTROINTESTINAL MOTILITY; GUAVA; MALE; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; PLANT LEAF; RAT; WISTAR RAT;

ANIMALS; ANTIDIARRHEALS; ATROPINE; CASTOR OIL; DIARRHEA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL MOTILITY; LOPERAMIDE; MALE; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; PLANT LEAVES; PSIDIUM; RATS; RATS, WISTAR;

EID: 65449137146     PISSN: 09168737     EISSN: 18848796     Source Type: Journal    
DOI: 10.1540/jsmr.44.195     Document Type: Article

References (42)

1. Abdullahi, A.L., Agho, M.O., Amos, S., Gamaniel, K.S. and Wambebe, C. (2001). Antidiarrhoeal activity of the aqueous extract of Terminalia avicennoides roots. Phytotherapy Res. 15: 431-434.
2. Adeyemi, O.O. and Akindele, A.J. (2008). Antidiarrhoeal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae). J. Ethnopharmacol. 116: 407-412.
3. Agunu, A., Yusuf, S., Andrew, G.O., Zezi, A.U. and Abdurahman, E.M. (2005). Evaluation of five medicinal plants used in diarrhoea treatment in Nigeria. J. Ethnopharmacol. 101: 27-30.
4. Akindele, A.J. and Adeyemi, O.O. (2006). Evaluation of the antidiarrhoeal activity of Byrsocarpus coccineus. J. Ethnopharmacol. 108: 20-25.
5. Aniagu, S.O., Binda, L.G., Nwinyi, F.C., Orisadipe, A., Amos, S., Wambebe, C. and Gamaniel, K. (2005). Anti-diarrhoeal and ulcer-protective effects of the aqueous root extract of Guiera senegalensis in rodents. J. Ethnopharmacol. 97: 549-554.
6. Arima, H. and Danno, G. (2002). Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci. Biotechnol. Biochem. 66: 1727-1730.
7. Avery, M.E. and Synder, J.D. (1990). Oral therapy for acute diarrhoea. Antenn. J. Med. 323: 891-894.
8. Awouters, F., Niemegeers, C.J.E., Lenaerts, F.M. and Janssen, P.A.J. (1978). Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. J. Pharm. Pharmacol. 30: 41-45.
9. Aye-Than, J.H., Kulkarni, W. and Tha, S.J. (1989). Antidiarrhoeal efficacy of some Burmese indigenous drug formulations in experimental diarrhoea models. Internat. J. Crude Drug Res. 27: 195-200.
10. Brunton, L.L. (1996). Agents for control of gastric acidity and treatment of peptic ulcers. In: Goodman and Gilman's 'The Pharmacological Basis of Therapeutics', 9th ed., McGaw-Hill, New York, pp. 901-915.
11. Dicarlo, G.D., Mascolo, N., Izzo, A.A., Capasso, F. and Autore, G. (1994). Effects of quercetin on gastrointestinal tract in rats and mice. Phytotherapy Res. 8: 42-45.
12. Dunnett, C. and Goldsmith, C. (1993). In: Statistics in the Pharmaceutical Industry, 2nd ed., ed. by C.R. Buncher and J.Y. Tsay, Marcel Dekker, New York.
13. Field, M., Rao, M.C. and Chang, E.B. (1989). Intestinal electrolyte transport and diarrhoea disease. New England J. Med. 321: 800-806.
14. Fontaine, O. (1988). Bacterial diarrhoea and treatment. Lancet 331: 1234-1235.
15. Gaginella, T. S., Stewart, J.J., Olsen, W.A. and Bass, P. (1975). Action of ricinoleic acid and structurallyrelated fatty acid on gastrointestinal tract. II. Effect on water and electrolyte absorption in vitro. J. Pharmacol. Exp. Ther. 195: 355-361.
16. Galvez, J., Duarte, J., Medina, F.S., Jimenez, J. and Zarzuelo, A. (1996). Inhibitory effects of quercetin on guinea-pig ileum contractions. Phytotherapy Res. 10: 66-69.
17. Gamaniel, K.S. and Akah, P.A. (1996). Analysis of the gastrointestinal relaxing effect of the stem-bark extract of Gongronema latifolium. Phytomed. 2: 293-296.
18. Gonçcalves, F.A., Andrade-Neto, M., Bezerra, J.N.S., Macrae, A., Sousa, O.V., Fonteles-Filho, A.A. and Vieira, R.H.S.F. (2008). Antibacterial activity of guava, Psidium guajava Linnaeus, leaf extracts on diarrhoea-causing enteric bacteria isolated from Seabob shrimp, Xiphopenaeus kroyeri (Heller). Rev. Inst. Med. Trop. S. Paulo 50: 11-15.
19. Gurgel, L.A., Silva, R.M., Santos, F.A., Martins, D.T.O., Mattos, P.O. and Rao, V.S.N. (2001). Studies on the antidiarrhoeal effect of dragon's blood from Croton Urucarana. Phytotherapy Res. 15: 319-322.
20. Gutierrez, R.M.P., Mitchell, S. and Solis, R.V. (2008). Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. J. Ethnopharmacol. 117: 1-27.
21. Hirchhorn, N. (1980). The treatment of acute diarrhoea in children: an historical and physiological perspective. Am. J. Clinic. Nutrit. 33: 637-663.
22. Longe, R.L. and Dipiro, J.T. (1992). Diarrhoea and constipation. In: Pharmacotherapy: A Pathophysiologic Approach, 2nd ed., ed. by J.T. Dipiro, R.L. Talbert and P.E. Hayes, Elsevier, New York, pp 566-578.
23. Lin, J., Puckree, T. and Mvelase, T.P. (2002). Anti-diarrhoeal evaluation of some medicinal plants used by Zulu traditional healers. J. Ethnopharmacol. 79: 53-56.
24. Lorke, D. (1983). A new approach to practical acute toxicity testing. Arch. Toxicol. 54: 275-287.
25. Lozoya, X., Reyes-Morales, H., Chavez-Soto, M.A., Martinez-Garci a, M.C., Soto-Gonzalez, Y. and Doubova, S.V. (2002). Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrhoeic disease. J. Ethnopharmacol. 83: 19-24.
26. Lutterodt, G.D. (1989). Inhibition of gastrointestinal release of acetylcholine by quercetin as a possible mode of action of Psidium guajava leaf extracts in the treatment of acute diarrhoeal disease. J. Ethnopharmacol. 25: 235-247.
27. Lutterodt, G.D., Ismail, A., Basheer, R.H. and Baharudin, H.M. (1999). Antimicrobial effects of Psidium guajava extract as one mechanism of its antidiarrhoeal action. Malaysian J. Med. Sci. 6: 17-20.
28. Mbagwu, H.O.C. and Adeyemi, O.O. (2008). Anti-diarrhoeal activity of the aqueous extract of Mezoneuron benthamianum Baill (Caesalpinaceae). J. Ethnopharmacol. 116: 16-20.
29. Morales, M.A., Tortoriello, J., Meckes, M., Paz, D. and Loxoya, X. (1994). Calcium-antagonist effect of quercetin and its relation with the spasmolytic properties of Psidium guajava L. Arch. Med. Res. 25: 17-21.
30. Mukherjee, P.K., Scha, K., Murugesan, T., Mandal, S.C., Pal, M. and Scha, B.P. (1998). Screening of antidiarrhoeal profiles of some plant extracts of specific regions of West Bengal, India. J. Ethnopharmacol. 60: 85-89.
31. Ojewole, J.A.O. (2005). Hypoglycaemic and hypotensive effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract. Meth. Find. Exp. Clinic. Pharmacol. 27: 689-695.
32. Ojewole, J.A.O. (2006). Anti-inflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. Meth. Find. Exp. Clinic. Pharmacol. 28: 441-446.
33. Olajide, O.A., Awe, S.O. and Makinde, J.M. (1999). Pharmacological studies on the leaf of Psidium guajava. Fitoterapia 70: 25-31.
34. Qian, H. and Nihorimbere, V. (2004). Antioxidant power of phytochemicals from Psidium guajava leaf. J. Science 5: 676-683.
35. Snyder, J.D. and Merson, M.H. (1982). The magnitude of the global problem of acute diarrhoeal disease: a review of acute surveillance data. Bull. World Health Organiz. 60: 604-613.
36. Suleiman, M.M., Dzenda, T. and Sani, C.A. (2008). Antidiarrhoeal activity of the methanol stem-bark extract of Annona senegalensis Pers. (Annonaceae). J. Ethnopharmacol. 116: 125-130.
37. Teixeira, R.O., Camparoto, M.L., Mantovani, M.S. and Vicentini, V.E.P. (2003). Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L., in in vitro and in vivo assays. Genet. Mol. Biol. 26: 551-555.
38. Van Wyk, B-E. and Wink, M. (2004). Medicinal Plants of the World, 1st ed., Briza Publications, Pretoria (South Africa), p. 258.
39. Van Wyk, B-E., Van Oudtshoorn, B. and Gericke, N. (2002). Medicinal Plants of South Africa, 2nd ed., Briza Publications, Pretoria, pp. 202-203.
40. Venkatesan, N., Thiyagarajan, V., Narayanan, S., Arul, A., Raja, S., Kumar, S.G.V., Rajarajan, T. and Perianayagam, J.B. (2005). Antidiarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals. J. Pharmacol. Pharm. Sci. 8: 39-45.
41. Vieira, R.H.S.F., Rodrigues, D.P., Gonçalves, F.A., Menezes, F.G. R., Aragao, J.S. and Sousa, O.V. (2001). Microbicidal effect of medicinal plant extracts (Psidium guajava Linn. and Carica papaya Linn.) upon bacteria isolated from fish muscle and known to induce diarrhoea in children. Rev. Inst. Med. Trop. S. Paulo 43: 145-148.
42. Watt, J.M. and Breyer-Brandwijk, M.G. (1962). Medicinal and Poisonous Plants of Southern and Eastern Africa, 2nd ed., E. & S. Livingstone Ltd., Edinburgh and London, pp. 798-799.