Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L., in vitro and in vivo assays

Genetics and Molecular Biology

Volumn 26, Issue 4, 2003, Pages 551-555

  de Oliveira Teixeira, Rosangela ^a   Camparoto, Marjori Leiva ^a   Mantovani, Mário Sérgio ^b   Pimenta Vicentini, Veronica Elisa ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Chromosome damage; Medicinal herbs; Mutagenicity test

Indexed keywords

ACHILLEA MILLEFOLIUM EXTRACT; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ASTRINGENT AGENT; DIURETIC AGENT; EMOLLIENT AGENT; PLANT EXTRACT; PSIDIUM GUAJAVA EXTRACT; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT;

ACHILLEA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL CYCLE; CHROMOSOME NUMBER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DIARRHEA; DRUG EFFICACY; DRUG INDICATION; DRUG INFUSION; DRUG SAFETY; FEMALE; GENOTOXICITY; GUAVA; HEMORRHOID; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; MITOSIS INHIBITION; NONHUMAN; ONION; PERIPHERAL LYMPHOCYTE; PLANT CELL; PLANT CHROMOSOME; PLANT ROOT; RAT STRAIN; STATISTICAL SIGNIFICANCE; TEA;

ACHILLEA; ACHILLEA MILLEFOLIUM; ALLIUM; ALLIUM CEPA; ANIMALIA; PSIDIUM; PSIDIUM GUAJAVA; RATTUS NORVEGICUS;

EID: 0347989247     PISSN: 14154757     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1415-47572003000400021     Document Type: Article

References (13)

1. Bu-Abbas A, Nunez X, Clifford MN, Walker R and Ioannides C (1996) A comparison of the antimutagenic potential of green, black and decaffeinated teas: contribution of flavanols to the antimutagenic effect. Mutagenesis 11:597-603.
2. Ford CE and Hamerton JL (1956) A colchicine, hypotonic citrate, squash sequence for mammalian chromosome. Stain Technology 31:247-251.
3. Horikawa K, Mohri T, Tanaka Y and Tokiwa H (1994) Moderate inhibition of mutagenicity and carcinogenicity of benzo[a]pyrene, 1,6-dinitropyrene and 3,9-dinitrofluoranthene by Chinese medicinal herbs. Mutagenesis 9:523-526.
4. Hoyos LS, Au WW, Heo MY, Morris DL and Legator MS (1992) Evaluation of the genotoxic effects of a folk medicine, Petiveria alliacea (anamu). Mutation Research 280:29-34.
5. Ishii R, Yoshikawa H, Minakata NT, Komura K and Kada T (1984) Specificity of bio-antimutagens in the plant kingdom. Agricultural and Biological Chemistry Journal 48:2587-2591.
6. Martins ER, Castro DM, Castellani DC and Dias JE (1995) Plantas Medicinais. Imprensa Universitária, Viçosa, MG, Brasil, pp 220.
7. Moorhead PS, Nowell PC, Mellman WJ, Battips DM and Hungerford DA (1960) Chromosome preparation of leukocytes cultured from human peripheral blood. Experimental Cell Research 20:613.
8. Ohtsuka M, Fukuda K, Yano H and Kojiro M (1995) Effects of nine active ingredients in Chinese herbal medicine sho-saiko-to on 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide mutagenicity, Japanese Journal of Cancer Research 86:1131-1135.
9. Pereira, CAB (1991) Teste estatístico para comparar proporções em problemas de citogenética. In: Rabello-Gay MN, Rodrigues MAR and Monteleone-Neto R (eds) Mutagênese, Teratogênese e Carcinogênese. Métodos e Critérios de Avaliação. Sociedade Brasileira de Genética, Ribeirão Preto, SP, pp 113-121.
10. Preston RJ, Au W, Bender MA, Brewen JG, Carrano AV, Heddle JA, Mcfee AF, Wolf S and Wassom JS (1981) Mammalian in vivo and in vitro cytogenetic assays: A report of the U.S.EPA's Gene-Tox Program Mutat Res 87:143-188.
11. Preston RJ, Dean BJ, Galloway S, Holden H, Mcfee AF and Shelby M (1987a) Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells. Mutat Res 189:157-165.
12. Preston RJ, San Sebastian, JR and Macfee AF (1987b) The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents. Mutat Res 189:175-183.
13. Silva I, Franco SL, Molinari SL, Conegero CI, Miranda Neto MH, Cardoso MLC, Sant'ana DMG and Iwanko, NS (1995) Noções Sobre o Organismo Humano e Utilização de Plantas Medicinais. Assoeste - Editora Educativa, Cascavel, PR, Brasil, pp 203.