Abnormal DNA methylation of the Oct-4 enhancer region in cloned mouse embryos

Molecular Reproduction and Development

Volumn 76, Issue 4, 2009, Pages 342-350

  Kawasumi, Miyuri ^a,b   Unno, Yuichi ^a   Matsuoka, Toshiki ^a   Nishiwaki, Megumi ^a   Anzai, Masayuki ^a   Amano, Tomoko ^a   Mitani, Tasuku ^a   Kato, Hiromi ^a   Saeki, Kazuhiro ^a   Hosoi, Yoshihiko ^a   Iritani, Akira ^a   Kishigami, Satoshi ^a   Matsumoto, Kazuya ^a,c  

^a KINKI UNIVERSITY   (Japan)

^b UNIVERSITY OF HAWAII   (United States)

^c NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTRANSFERASE; METHYLTRANSFERASE 3B; OCTAMER TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; DNA METHYLATION; DOWN REGULATION; EMBRYO; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR CLONING; MORULA; MOUSE; NIDATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; ANIMAL; ANIMAL EMBRYO; CELL NUCLEUS TRANSPLANTATION; CLONING; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PREGNANCY;

ANIMALS; BLASTOCYST; CLONING, ORGANISM; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EMBRYO, MAMMALIAN; ENHANCER ELEMENTS, GENETIC; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; NUCLEAR TRANSFER TECHNIQUES; OCTAMER TRANSCRIPTION FACTOR-3; PREGNANCY;

EID: 65449122024     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20966     Document Type: Article

References (47)

1. Barnea E, Bergman Y. 2000. Synergy of SF1 and RAR in activation of Oct-3/4 promoter. J Biol Chem 275:6608-6619.
2. Ben-Shushan E, Pikarsky E, Klar A, Bergman Y. 1993. Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methyla- tion status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region. Mol Cell Biol 13:891-901.
3. Ben-Shushan E, Sharir H, Pikarsky E, Bergman Y. 1995. Adynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor: Retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol 15:1034-1048.
4. Beyhan Z, Forsberg EJ, Eilertsen KJ, Kent-First M, First NL. 2007. Gene expression in bovine nuclear transfer embryos in relation to donor cell efficiency in producing live offspring. Mol Reprod Dev 74:18-27.
5. Boiani M, Eckardt S, Scholer HR, McLaughlin KJ. 2002. Oct4 distribution and level in mouse clones: Consequences for pluripotency. Genes Dev 16:1209-1219.
6. Boiani M, Gentile L, Gambles VV, Cavaleri F, Redi CA, Scholer HR. 2005. Variable reprogramming of the pluripotent stem cell marker Oct4 in mouse clones: Distinct developmental potentials in different culture environments. Stem Cells 23:1089-1104.
7. Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R. 2003. Incomplete reactivation of Oct4- related genes in mouse embryos cloned from somatic nuclei. Development 130:1673-1680.
8. Brehm A, Ohbo K, Schooler HR. 1997. The carboxy-terminal trans- activation domain of Oct-4 acquires cells specificity through the POU domain. Mol Cell Biol 17:154-162.
9. Cavaleri FM, Balbach ST, Gentile L, Jauch A, Bohm-Steuer B, Han YM, Schooler HR, Boiani M. 2008. Subsets of cloned mouse embryos and their non-random relationship to development and nuclear reprogramming. Mech Dev 125:153-166.
10. Chung YG, Ratnam S, Chaillet JR, Latham KE. 2003. Abnormal regulation of DNA methyltransferase expression in cloned mouse embryos. Biol Reprod 69:146-153.
11. Fatemi M, Hermann A, Gowher H, Jeltsch A. 2002. Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur J Biochem 269:4981-4984.
12. Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y. 2006. G9a-mediated irreversible epigenetic inacti- vation of Oct-3/4 during early embryogenesis. Nat Cell Biol 8:188-194.
13. Fuhrmann G, Chung AC, Jackson KJ, Hummelke G, Baniahmad A, Sutter J, Sylvester I, Scholer HR, Cooney AJ. 2001. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 1:377-387.
14. Gidekel S, Bergman Y. 2002. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J Biol Chem 277:34521 -34530.
15. Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, LatourAM, Koller BH, Gossen J, KliewerSA, Cooney AJ. 2005. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development.
16. Mol Cell Biol 25:3492-3505.
17. Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, Shiota K. 2004. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem 279:17063-17069.
18. Kawasumi M, Anzai M,TakeharaT, MitaniT, Kato H, Saeki K, Iritani A, Matsumoto K, Hosoi Y. 2007. Abnormal distribution of chromosomes in the first division of nuclear transferred mouse embryos. J Reprod Dev 53:615-622.
19. Kishigami S, Wakayama S, Thuan NV, Ohta H, Mizutani E, Hikichi T, Bui HT, Balbach S, Ogura A, Boiani M, Wakayama T. 2006a. Production of cloned mice by somatic cell nuclear transfer. Nat Protoc 1:125-138.
20. Kishigami S, Hikichi T, Van Thuan N, Ohta H, Wakayama S, Bui HT, Mizutani E, Wakayama T. 2006b. Normal specification of the extraembryonic lineage after somatic nuclear transfer. FEBS Lett 580:1801-1806.
21. Kurihara Y, Kawamura Y, Uchijima Y, Amano T, Kobayashi H, Asano T, Kurihara H. 2008. Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase1. Dev Biol 313:335-346.
22. Latham KE. 2004. Cloning: Questions answered and unsolved. Differentiation 72:11-22.
23. Li X, Kato Y, Tsunoda Y. 2005. Comparative analysis of development-related gene expression in mouse preimplantation embryos with different developmental potential. Mol Reprod Dev 72:152-160.
24. Li X, Kato Y, Tsunoda Y. 2006. Comparative studies on the mRNA expression of development-related genes in an individual mouse blastocyst with different developmental potential. Cloning Stem Cells 8:214-224.
25. Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, Jing NH, Chen T, Li E, Sasaki H, Xu GL. 2007. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol 27:8748-8759.
26. Marikawa Y, Fujita TC, Alarcon VB. 2005. Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population. Cloning Stem Cells 7:8-16.
27. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Scholer H, Smith A. 1998. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-391.
28. Niwa H, Miyazaki J, Smith AG. 2000. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376.
29. Niwa H, Toyooka Y, Shimosato D, StrumpfD, Takahashi K, Yagi R, Rossant J. 2005. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123:917-929.
30. Nordhoff V, Hubner K, Bauer A, Orlova I, Malapetsa A, Scholer HR. 2001. Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. Mamm Genome 12:309-317.
31. Okano M, Bell DW, Haber DA, Li E. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247-257.
32. Okumura-Nakanishi S, Saito M, Niwa H, Ishikawa F. 2005. Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem 280:5307-5317.
33. Ovitt CE, Scholer HR. 1998. The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod 4:1021 -1031.
34. Pesce M, Gross MK, Schooler HR. 1998. In line with our ancestors: Oct-4 and the mammalian germ. Bioessays 20:722-732.
35. Pesce M, Marin Gomez M, Philipsen S, Scholer HR. 1999. Binding of Sp1 and Sp3 transcription factors to the Oct-4 gene promoter. Cell Mol Biol 45:709-716.
36. Ratnam S, Mertineit C, Ding F, Howell CY, Clarke HJ, Bestor TH, Chaillet JR, Trasler JM. 2002. Dynamics ofDnmt1 methyltrans- ferase expression and intracellular localization during oogenesis and preimplantation development. Dev Biol 245:304-314.
37. Sato N, Kondo M, Arai K. 2006. The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. Biochem Biophys Res Commun 344:845-851.
38. Schoorlemmer J, van Puijenbroek A, van Den Eijnden M, Jonk L, Pals C, Kruijer W. 1994. Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Mol Cell Biol 14:1122-1136.
39. Sebastiano V, Gentile L, Garagna S, Redi CA, Zuccotti M. 2005. Cloned pre-implantation mouse embryos show correct timing but altered levels of gene expression. Mol Reprod Dev 70:146-154.
40. Tamashiro KL, Wakayama T, Akutsu H, Yamazaki Y, Lachey JL, Wortman MD, Seeley RJ, D'Alessio DA, Woods SC, Yanagima- chi R, Sakai RR. 2002. Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med 8:262-267.
41. Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R. 1998. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 394:369-374.
42. Wakayama T, Rodriguez I, Perry AC, Yanagimachi R, Mombaerts P. 1999. Mice cloned from embryonic stem cells. Proc Natl Acad Sci USA 96:14984-14989.
43. Watanabe D, Suetake I, Tada T, Tajima S. 2002. Stage- and cell- specific expression of Dnmt3a and Dnmt3b during embryogene- sis. Mech Dev 118:187-190.
44. Wei F, Schooler HR, Atchison ML. 2007. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem 282:21551-21560.
45. Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, Sheng HZ, Zhao YX, Zhao YM, Jin Y. 2004. Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279:23495-23503.
46. Yamazaki Y, Fujita TC, Low EW, Alarcoon VB, Yanagimachi R, Marikawa Y. 2006. Gradual DNA demethylation of the Oct4 promoter in cloned mouse embryos. Mol Reprod Dev 73:180-188.
47. Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, Gross M, Hubner K, Scholer HR. 1996. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122:881-894.