Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2661-2663

  Ralbovsky, Janet L ^a   Lisko, Joseph G ^a   Palmer, Jeffrey M ^a   Mabus, John ^a   Chevalier, Kristen M ^a   Schulz, Mark J ^a   Dyatkin, Alexey B ^a   Miskowski, Tamara A ^a   Coats, Steven J ^a   Hornby, Pamela ^a   He, Wei ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

PK1; Prokineticin; Triazinediones

Indexed keywords

ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR; GROWTH FACTOR RECEPTOR; GUANIDINE DERIVATIVE; PROKINETICIN 1 RECEPTOR ANTAGONIST; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ILEUM; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE; HUMANS; RATS; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

RATTUS;

EID: 65349195100     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.157     Document Type: Article

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