New and novel markers for prostate cancer detection

Current Urology Reports

Volumn 10, Issue 3, 2009, Pages 179-186

  Lin, Daniel W ^a   Risk, Michael C ^b  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; APC PROTEIN; ARF PROTEIN; DD3 PROTEIN; EPCA PROTEIN; EPCA2 PROTEIN; GLUTATHIONE TRANSFERASE P1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NUCLEAR PROTEIN; PROSTATE PROTEIN; PROTEIN P16; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR TMPRSS2; TUMOR MARKER; UNCLASSIFIED DRUG;

CANCER DIAGNOSIS; CANCER MODEL; CANCER RECURRENCE; CANCER RISK; CHROMOSOME TRANSLOCATION; DIAGNOSTIC VALUE; DIGITAL RECTAL EXAMINATION; DNA METHYLATION; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL PROTEOMICS; GENE FUSION; GENE IDENTIFICATION; GENETIC ANALYSIS; HUMAN; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; NONHUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROSTATE BIOPSY; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SENSITIVITY AND SPECIFICITY; SERUM; URINE;

ANTIGENS, NEOPLASM; DIAGNOSIS, DIFFERENTIAL; HUMANS; MALE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 65349173746     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-009-0031-x     Document Type: Review

References (66)

1. T.A. Stamey N. Yang A.R. Hay 1987 Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate N Engl J Med 317 909 916 (Pubitemid 17147932)
2. C.J. Ercole P.H. Lange M. Mathisen 1987 Prostatic specific antigen and prostatic acid phosphatase in the monitoring and staging of patients with prostatic cancer J Urol 138 1181 1184 (Pubitemid 17157542)
3. R. Etzioni D.F. Penson J.M. Legler 2002 Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends J Natl Cancer Inst 94 981 990
4. I.M. Thompson D.K. Pauler P.J. Goodman 2004 Prevalence of prostate cancer among men with a prostate-specific antigen level < or = 4.0 ng per milliliter N Engl J Med 350 2239 2246 (Pubitemid 38669206)
5. Stephenson AJ, Jones JS, Hernandez AV, et al.: Analysis of T1c prostate cancers treated at very low prostate-specific antigen levels. Eur Urol 2008 July 14 (Epub ahead of print).
6. M.A. Rubin M. Zhou S.M. Dhanasekaran 2002 alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer JAMA 287 1662 1670 (Pubitemid 34289218)
7. J. Luo S. Zha W.R. Gage 2002 Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer Cancer Res 62 2220 2226 (Pubitemid 34411693)
8. Z. Jiang C.L. Wu B.A. Woda 2004 Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker Histopathology 45 218 225 (Pubitemid 39294698)
9. C. Kumar-Sinha R.B. Shah B. Laxman 2004 Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer Am J Pathol 164 787 793 (Pubitemid 38235461)
10. P.J. Zielie J.A. Mobley R.G. Ebb 2004 A novel diagnostic test for prostate cancer emerges from the determination of alpha-methylacyl-coenzyme a racemase in prostatic secretions J Urol 172 1130 1133 (Pubitemid 39096486)
11. C.G. Rogers G. Yan S. Zha 2004 Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein J Urol 172 1501 1503 (Pubitemid 39249757)
12. D. Maraldo F.U. Garcia R. Mutharasan 2007 Method for quantification of a prostate cancer biomarker in urine without sample preparation Anal Chem 79 7683 7690 (Pubitemid 47622396)
13. A. Sreekumar B. Laxman D.R. Rhodes 2004 Humoral immune response to alpha-methylacyl-CoA racemase and prostate cancer J Natl Cancer Inst 96 834 843 (Pubitemid 38807604)
14. S.V. Bradley K.I. Oravecz-Wilson G. Bougeard 2005 Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer Cancer Res 65 4126 4133 (Pubitemid 40775650)
15. R.H. Getzenberg K.J. Pienta E.Y. Huang D.S. Coffey 1991 Identification of nuclear matrix proteins in the cancer and normal rat prostate Cancer Res 51 6514 6520
16. A.W. Partin R.H. Getzenberg M.J. CarMichael 1993 Nuclear matrix protein patterns in human benign prostatic hyperplasia and prostate cancer Cancer Res 53 744 746 (Pubitemid 23077855)
17. R. Dhir B. Vietmeier J. Arlotti 2004 Early identification of individuals with prostate cancer in negative biopsies J Urol 171 1419 1423 (Pubitemid 38365385)
18. H. Uetsuki H. Tsunemori R. Taoka 2005 Expression of a novel biomarker, EPCA, in adenocarcinomas and precancerous lesions in the prostate J Urol 174 514 518 (Pubitemid 40981588)
19. B. Paul R. Dhir D. Landsittel 2005 Detection of prostate cancer with a blood-based assay for early prostate cancer antigen Cancer Res 65 4097 4100 (Pubitemid 40775646)
20. E.S. Leman G.W. Cannon B.J. Trock 2007 EPCA-2: a highly specific serum marker for prostate cancer Urology 69 714 720 (Pubitemid 46574950)
21. M.J. Bussemakers A. van Bokhoven G.W. Verhaegh 1999 DD3: a new prostate-specific gene, highly overexpressed in prostate cancer Cancer Res 59 5975 5979 (Pubitemid 30004960)
22. J.B. de Kok G.W. Verhaegh R.W. Roelofs 2002 DD3(PCA3), a very sensitive and specific marker to detect prostate tumors Cancer Res 62 2695 2698 (Pubitemid 34462754)
23. L.J. Sokoll W. Ellis P. Lange 2008 A multicenter evaluation of the PCA3 molecular urine test: pre-analytical effects, analytical performance, and diagnostic accuracy Clin Chim Acta 389 1 6
24. M.P. van Gils D. Hessels O. van Hooij 2007 The time-resolved fluorescence-based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance Clin Cancer Res 13 939 943 (Pubitemid 46340370)
25. J. Groskopf S.M. Aubin I.L. Deras 2006 APTIMA PCA3 molecular urine test: development of a method to aid in the diagnosis of prostate cancer Clin Chem 52 1089 1095 (Pubitemid 43794421)
26. I.L. Deras S.M. Aubin A. Blase 2008 PCA3: a molecular urine assay for predicting prostate biopsy outcome J Urol 179 1587 1592
27. L.S. Marks Y. Fradet I.L. Deras 2007 PCA3 molecular urine assay for prostate cancer in men undergoing repeat biopsy Urology 69 532 535 (Pubitemid 46428401)
28. A. Haese A. de la Taille H. van Poppel 2008 Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy Eur Urol 54 1081 1088
29. H. Nakanishi J. Groskopf H.A. Fritsche 2008 PCA3 molecular urine assay correlates with prostate cancer tumor volume: implication in selecting candidates for active surveillance J Urol 179 1804 1809
30. E.J. Whitman J. Groskopf A. Ali 2008 PCA3 score before radical prostatectomy predicts extracapsular extension and tumor volume J Urol 180 1975 1978
31. W.H. Lee R.A. Morton J.I. Epstein 1994 Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis Proc Natl Acad Sci U S A 91 11733 11737 (Pubitemid 24356419)
32. W.H. Lee W.B. Isaacs G.S. Bova W.G. Nelson 1997 CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: a new prostate cancer biomarker Cancer Epidemiol Biomarkers Prev 6 443 450 (Pubitemid 27270550)
33. C. Jeronimo H. Usadel R. Henrique 2001 Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma J Natl Cancer Inst 93 1747 1752 (Pubitemid 33130264)
34. J.D. Brooks M. Weinstein X. Lin 1998 CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia Cancer Epidemiol Biomarkers Prev 7 531 536 (Pubitemid 28354117)
35. S.V. Harden H. Sanderson S.N. Goodman 2003 Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies J Natl Cancer Inst 95 1634 1637 (Pubitemid 37455931)
36. H. Enokida H. Shiina S. Urakami 2005 Multigene methylation analysis for detection and staging of prostate cancer Clin Cancer Res 11 6582 6588 (Pubitemid 41338998)
37. C. Jeronimo R. Henrique M.O. Hoque 2004 A quantitative promoter methylation profile of prostate cancer Clin Cancer Res 10 8472 8478 (Pubitemid 40053412)
38. R. Henrique F.R. Ribeiro D. Fonseca 2007 High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients Clin Cancer Res 13 6122 6129 (Pubitemid 350075071)
39. E. Rosenbaum M.O. Hoque Y. Cohen 2005 Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy Clin Cancer Res 11 8321 8325 (Pubitemid 41746943)
40. C. Goessl M. Muller R. Heicappell 2001 DNA-based detection of prostate cancer in urine after prostatic massage Urology 58 335 338 (Pubitemid 32816344)
41. M.O. Hoque O. Topaloglu S. Begum 2005 Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects J Clin Oncol 23 6569 6575 (Pubitemid 46190250)
42. M. Roupret V. Hupertan D.R. Yates 2007 Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage Clin Cancer Res 13 1720 1725 (Pubitemid 46952937)
43. T. Vener C. Derecho J. Baden 2008 Development of a multiplexed urine assay for prostate cancer diagnosis Clin Chem 54 874 882
44. K. Woodson K.J. O'Reilly J.C. Hanson 2008 The usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate cancer J Urol 179 508 511
45. S.A. Tomlins D.R. Rhodes S. Perner 2005 Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer Science 310 644 648 (Pubitemid 41528150)
46. R. Mehra S.A. Tomlins R. Shen 2007 Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer Mod Pathol 20 538 544 (Pubitemid 46631996)
47. S.A. Tomlins R. Mehra D.R. Rhodes 2006 TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer Cancer Res 66 3396 3400
48. B.E. Helgeson S.A. Tomlins N. Shah 2008 Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer Cancer Res 68 73 80
49. B. Han R. Mehra S.M. Dhanasekaran 2008 A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer Cancer Res 68 7629 7637
50. G. Petrovics A. Liu S. Shaheduzzaman 2005 Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome Oncogene 24 3847 3852 (Pubitemid 40826884)
51. A.B. Rajput M.A. Miller A. De Luca 2007 Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers J Clin Pathol 60 1238 1243 (Pubitemid 350084545)
52. S. Perner F. Demichelis R. Beroukhim 2006 TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer Cancer Res 66 8337 8341 (Pubitemid 44449140)
53. O.R. Saramaki A.E. Harjula P.M. Martikainen 2008 TMPRSS2:ERG fusion identifies a subgroup of prostate cancers with a favorable prognosis Clin Cancer Res 14 3395 3400
54. R.K. Nam L. Sugar W. Yang 2007 Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer Br J Cancer 97 1690 1695 (Pubitemid 350249347)
55. F. Demichelis K. Fall S. Perner 2007 TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort Oncogene 26 4596 4599 (Pubitemid 47037039)
56. J.C. Cheville R.J. Karnes T.M. Therneau 2008 Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy J Clin Oncol 26 3930 3936
57. J. Wang Y. Cai C. Ren M. Ittmann 2006 Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer Cancer Res 66 8347 8351 (Pubitemid 44449142)
58. N. Cerveira F.R. Ribeiro A. Peixoto 2006 TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions Neoplasia 8 826 832 (Pubitemid 44564838)
59. J.M. Mosquera S. Perner E.M. Genega 2008 Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications Clin Cancer Res 14 3380 3385
60. M.R. Teixeira 2008 Chromosome mechanisms giving rise to the TMPRSS2-ERG fusion oncogene in prostate cancer and HGPIN lesions Am J Surg Pathol 32 642 644
61. O. Klezovitch M. Risk I. Coleman 2008 A causal role for ERG in neoplastic transformation of prostate epithelium Proc Natl Acad Sci U S A 105 2105 2110
62. S.A. Tomlins B. Laxman S. Varambally 2008 Role of the TMPRSS2-ERG gene fusion in prostate cancer Neoplasia 10 177 188
63. B. Laxman S.A. Tomlins R. Mehra 2006 Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer Neoplasia 8 885 888
64. D. Hessels F.P. Smit G.W. Verhaegh 2007 Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer Clin Cancer Res 13 5103 5108 (Pubitemid 47502077)
65. B. Laxman D.S. Morris J. Yu 2008 A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer Cancer Res 68 645 649
66. J.P. Clark K.W. Munson J.W. Gu 2008 Performance of a single assay for both type III and type VI TMPRSS2:ERG fusions in noninvasive prediction of prostate biopsy outcome Clin Chem 54 1 11 (Pubitemid 352774034)