Antileukemic mechanism of resveratrol in vitro and in mice bearing L1210-tumor

Journal of Chinese Integrative Medicine

Volumn 6, Issue 12, 2008, Pages 1267-1274

  Li, Tan ^a   Wang, Wei ^a   Li, Tong ^b  

^a MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^b Xinjiang Armed Police General Hospital   (China)

Author keywords

Apoptosis; In vitro study; Interleukin 6; Leukemia; Mice; Resveratrol; Signal transducing adaptor proteins; STAT3 transcription factor

Indexed keywords

ANTILEUKEMIC AGENT; INTERLEUKIN 6; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; RESVERATROL; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLORIMETRY; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LEUKEMIA CELL LINE; LEUKEMIA L 1210; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; STILBENES;

EID: 65349165195     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20081212     Document Type: Article

References (11)

1. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997; 275 (5297): 218-220.
2. Yu HB, Pan CE, Wu WJ, et al. Effects of resveratrol on matrix metalloproteinase-9 expression in hepatoma cells. Zhong Xi Yi Jie He Xue Bao. 2008; 6(3): 270-273. Chinese with abstract in English.
3. Fulda S, Debatin KM. Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. Cancer Detect Prev. 2006; 30(3): 217-223.
4. Zhou YP. Randomized block design with Excel software in drug toxicology research. Yao Xue Jin Zhan. 2005; 29(9): 425-427. Chinese with abstract in English.
5. Wang Q, Li H, Liu N, et al. Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells. Neurosci Lett. 2008; 438(2): 168-173.
6. Radogna F, Cristofanon S, Paternoster L, et al. Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. J Pineal Res. 2008; 44(3): 316-325.
7. Li Y, Suo XH, Niu ZY. The changes and clinical significance of levels of IL-2 and IL-6 in pre and post chemotherapy of acute leukemia patients. Zhongguo Shi Yan Zhen Duan Xue. 2007; 11 (3): 324-326. Chinese with abstract in English.
8. Yin HQ, Qiao ZH, Zhu L, et al. Levels of intracellular IL-6 and IFN-γ in children with acute lymphoblastic leukemia. Zhongguo Dang Dai Er Ke Za Zhi. 2006; 8 (6): 461-463. Chinese with abstract in English.
9. Takada Y, Bhardwaj A, Potdar P, et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004; 23 (57): 9247-9258.
10. Yu LJ, Wu ML, Li H, et al. Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia. 2008; 10 (7): 736-744.
11. Wung BS, Hsu MC, Wu CC, et al. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci. 2005; 78(4): 389-397.