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Volumn 296, Issue 3, 2009, Pages

Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects

Author keywords

Brain gut axis; Cholecyctokinin; Glucagon like peptide 1; Glucose dependent insulinotropic polypeptide; Obesity; Pancreatic polypeptide; Peptide YY

Indexed keywords

CHOLECYSTOKININ; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; INSULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; TETRAHYDROLIPSTATIN; ANTIOBESITY AGENT; LACTONE;

EID: 65349151980     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90209.2008     Document Type: Article
Times cited : (21)

References (41)
  • 2
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 132: 2131-2157, 2007.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 4
    • 0034074389 scopus 로고    scopus 로고
    • Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: A study with orlistat, a highly specific lipase inhibitor
    • Borovicka J, Schwizer W, Guttmann G, Hartmann D, Kosinski M, Wastiel C, Bischof-Delaloye A, Fried M. Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor. Gut 46: 774-781, 2000.
    • (2000) Gut , vol.46 , pp. 774-781
    • Borovicka, J.1    Schwizer, W.2    Guttmann, G.3    Hartmann, D.4    Kosinski, M.5    Wastiel, C.6    Bischof-Delaloye, A.7    Fried, M.8
  • 10
    • 33644669454 scopus 로고    scopus 로고
    • Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid
    • Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR, Horowitz M. Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Am J Physiol Endocrinol Metab 289: E948-E953, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Feinle-Bisset, C.1    Patterson, M.2    Ghatei, M.A.3    Bloom, S.R.4    Horowitz, M.5
  • 12
    • 0030481873 scopus 로고    scopus 로고
    • Influence of orlistat on the regulation of gallbladder contraction in man: A randomized double-blind placebo-controlled crossover study
    • Froehlich F, Hartmann D, Guzelhan C, Gonvers JJ, Jansen JB, Fried M. Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study. Dig Dis Sci 41: 2404-2408, 1996.
    • (1996) Dig Dis Sci , vol.41 , pp. 2404-2408
    • Froehlich, F.1    Hartmann, D.2    Guzelhan, C.3    Gonvers, J.J.4    Jansen, J.B.5    Fried, M.6
  • 13
    • 34447127048 scopus 로고    scopus 로고
    • Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets
    • Gault VA, McClean PL, Cassidy RS, Irwin N, Flatt PR. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia 50: 1752-1762, 2007.
    • (2007) Diabetologia , vol.50 , pp. 1752-1762
    • Gault, V.A.1    McClean, P.L.2    Cassidy, R.S.3    Irwin, N.4    Flatt, P.R.5
  • 14
    • 0038116505 scopus 로고    scopus 로고
    • Chylomicron components activate duodenal vagal afferents via a cholecystokinin A receptor-mediated pathway to inhibit gastric motor function in the rat
    • Glatzle J, Wang Y, Adelson DW, Kalogeris TJ, Zittel TT, Tso P, Wei JY, Raybould HE. Chylomicron components activate duodenal vagal afferents via a cholecystokinin A receptor-mediated pathway to inhibit gastric motor function in the rat. J Physiol 550: 657-664, 2003.
    • (2003) J Physiol , vol.550 , pp. 657-664
    • Glatzle, J.1    Wang, Y.2    Adelson, D.W.3    Kalogeris, T.J.4    Zittel, T.T.5    Tso, P.6    Wei, J.Y.7    Raybould, H.E.8
  • 15
    • 53749083810 scopus 로고    scopus 로고
    • Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
    • Ellrichmann M, Kapelle M, Ritter PR, Holst JJ, Herzig KH, Schmidt WE, Schmitz F, Meier JJ. Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations. J Clin Endocrinol Metab 93: 3995-3998, 2008.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3995-3998
    • Ellrichmann, M.1    Kapelle, M.2    Ritter, P.R.3    Holst, J.J.4    Herzig, K.H.5    Schmidt, W.E.6    Schmitz, F.7    Meier, J.J.8
  • 16
    • 0346250173 scopus 로고    scopus 로고
    • Effects of a lipase inhibitor (Orlistat) on cholecystokinin and appetite in response to a high-fat meal
    • Goedecke JH, Barsdorf M, Beglinger C, Levitt NS, Lambert EV. Effects of a lipase inhibitor (Orlistat) on cholecystokinin and appetite in response to a high-fat meal. Int J Obes 27: 1479-1485, 2003.
    • (2003) Int J Obes , vol.27 , pp. 1479-1485
    • Goedecke, J.H.1    Barsdorf, M.2    Beglinger, C.3    Levitt, N.S.4    Lambert, E.V.5
  • 17
    • 0024202729 scopus 로고
    • Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin
    • Hadvary P, Lengsfeld H, Wolfer H. Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. Biochem J 256: 357-361, 1988.
    • (1988) Biochem J , vol.256 , pp. 357-361
    • Hadvary, P.1    Lengsfeld, H.2    Wolfer, H.3
  • 19
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 87: 1409-1439, 2007.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 28
    • 0142167935 scopus 로고    scopus 로고
    • Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects
    • O'Donovan D, Feinle-Bisset C, Wishart J, Horowitz M. Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects. Br J Nutr 90: 849-852, 2003.
    • (2003) Br J Nutr , vol.90 , pp. 849-852
    • O'Donovan, D.1    Feinle-Bisset, C.2    Wishart, J.3    Horowitz, M.4
  • 29
    • 12944280251 scopus 로고    scopus 로고
    • Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/carbohydrate meal in type 2 diabetes
    • O'Donovan D, Horowitz M, Russo A, Feinle-Bisset C, Murolo N, Gentilcore D, Wishart JM, Morris HA, Jones KL. Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/carbohydrate meal in type 2 diabetes. Diabetologia 47: 2208-2214, 2004.
    • (2004) Diabetologia , vol.47 , pp. 2208-2214
    • O'Donovan, D.1    Horowitz, M.2    Russo, A.3    Feinle-Bisset, C.4    Murolo, N.5    Gentilcore, D.6    Wishart, J.M.7    Morris, H.A.8    Jones, K.L.9
  • 32
    • 0031900774 scopus 로고    scopus 로고
    • Accurate measurement of cholecystokinin in plasma
    • Rehfeld JF. Accurate measurement of cholecystokinin in plasma. Clin Chem 44: 991-1001, 1998.
    • (1998) Clin Chem , vol.44 , pp. 991-1001
    • Rehfeld, J.F.1
  • 34
    • 30944467225 scopus 로고    scopus 로고
    • Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
    • Schirra J, Nicolaus M, Roggel R, Katschinski M, Storr M, Woerle HJ, Göke B. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans. Gut 55: 243-251, 2006.
    • (2006) Gut , vol.55 , pp. 243-251
    • Schirra, J.1    Nicolaus, M.2    Roggel, R.3    Katschinski, M.4    Storr, M.5    Woerle, H.J.6    Göke, B.7
  • 35
    • 0021026804 scopus 로고
    • Pancreatic polypeptide: A hormone under vagal control
    • Schwartz TW. Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 85: 1411-1425, 1983.
    • (1983) Gastroenterology , vol.85 , pp. 1411-1425
    • Schwartz, T.W.1
  • 38
    • 36549010103 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation
    • Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology 133: 1796-1805, 2007.
    • (2007) Gastroenterology , vol.133 , pp. 1796-1805
    • Song, D.H.1    Getty-Kaushik, L.2    Tseng, E.3    Simon, J.4    Corkey, B.E.5    Wolfe, M.M.6
  • 39
    • 0037902984 scopus 로고    scopus 로고
    • Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    • Vilsbøll T, Krarup T, Sonne J, Madsbad S, Vølund A, Juul AG, Holst JJ. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 88: 2706-2713, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2706-2713
    • Vilsbøll, T.1    Krarup, T.2    Sonne, J.3    Madsbad, S.4    Vølund, A.5    Juul, A.G.6    Holst, J.J.7
  • 40
    • 0031767175 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow
    • Wettergren A, Wøjdemann M, Holst JJ. Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. Am J Physiol Gastrointest Liver Physiol 275: G984-G992, 1998.
    • (1998) Am J Physiol Gastrointest Liver Physiol , vol.275
    • Wettergren, A.1    Wøjdemann, M.2    Holst, J.J.3
  • 41
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • Yip RGC, Wolfe M. GIP biology and fat metabolism. Life Sci 66: 91-103, 2000.
    • (2000) Life Sci , vol.66 , pp. 91-103
    • Yip, R.G.C.1    Wolfe, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.