Two-photon in vivo flow cytometry using a fiber probe

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7173, Issue , 2009, Pages

  Chang, Yu Chung ^a   Ye, Jing Yong ^a,b   Thomas, Thommey P ^b   Cao, Zhengyi ^b   Kotlyar, Alina ^b   Tkaczyk, Eric R ^a,b   Baker Jr , James R ^b   Norris, Theodore B ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Cancer; Circulating tumor cell; Double clad fiber; Fiber probe; Green fluorescent protein (GFP); In vivo flow cytometry; Metastasis; Two photon fluorescence

Indexed keywords

CANCER; CIRCULATING TUMOR CELL; DOUBLE-CLAD FIBER; FIBER PROBE; GREEN FLUORESCENT PROTEIN (GFP); IN VIVO FLOW CYTOMETRY; METASTASIS; TWO-PHOTON FLUORESCENCE;

ARCHITECTURAL DESIGN; BLOOD; FIBERS; FLOW CYTOMETRY; FLUORESCENCE; MULTIPHOTON PROCESSES; OPTICAL FIBERS; OPTICAL MATERIALS; OPTICAL SENSORS; PATHOLOGY; PHOTONS; PROBES; PROTEINS; TUMORS;

CELL MEMBRANES;

EID: 65349135890     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.808436     Document Type: Conference Paper

References (19)

1. K. Pantel, R. H. Brakenhoff, and B. Brandt, "Detection, clinical relevance and specific biological properties of disseminating tumour cells," Nat Rev Cancer 8, 329-340 (2008).
2. R. Weissleder, and M. J. Pittet, "Imaging in the era of molecular oncology," Nature 452, 580-589 (2008).
3. M. Cristofanilli, G. T. Budd, M. J. Ellis, A. Stopeck, J. Matera, M. C. Miller, J. M. Reuben, G. V. Doyle, W. J. Allard, L. W. Terstappen, and D. F. Hayes, "Circulating tumor cells, disease progression, and survival in metastatic breast cancer," N Engl J Med 351, 781-791 (2004).
4. W. He, H. F. Wang, L. C. Hartmann, J. X. Cheng, and P. S. Low, "In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry," Proceedings of the National Academy of Sciences of the United States of America 104, 11760-11765 (2007).
5. E. R. Tkaczyk, C. F. Zhong, J. Y. Ye, A. Myc, T. Thomas, Z. Cao, R. Duran-Struuck, K. E. Luker, G. D. Luker, T. B. Norris, and J. R. Baker, "In vivo monitoring of multiple circulating cell populations using two-photon flow cytometry," Optics Communications 281, 888-894 (2008).
6. C. F. Zhong, E. R. Tkaczyk, T. Thomas, J. Y. Ye, A. Myc, A. U. Bielinska, Z. Cao, I. Majoros, B. Keszler, J. R. Baker, and T. B. Norris, "Quantitative two-photon flow cytometry-in vitro and in vivo," J Biomed Opt 13, 034008 (2008).
7. J. Novak, I. Georgakoudi, X. Wei, A. Prossin, and C. P. Lin, "In vivo flow cytometer for real-time detection and quantification of circulating cells," Optics Letters 29, 77-79 (2004).
8. S. Boutrus, C. Greiner, D. Hwu, M. Chan, C. Kuperwasser, C. P. Lin, and I. Georgakoudi, "Portable two-color in vivo flow cytometer for real-time detection of fluorescently-labeled circulating cells," J Biomed Opt 12, 020507 (2007).
9. C. Alt, I. Veilleux, H. Lee, C. M. Pitsillides, D. Cote, and C. P. Lin, "Retinal flow cytometer," Opt Lett 32, 3450-3452 (2007).
10. J. Y. Ye, M. T. Myaing, T. B. Norris, T. Thomas, and J. Baker, "Biosensing based on two-photon fluorescence measurements through optical fibers," Optics Letters 27, 1412-1414 (2002).
11. T. P. Thomas, M. T. Myaing, J. Y. Ye, K. Candido, A. Kotlyar, J. Beals, P. Cao, B. Keszler, A. K. Patri, T. B. Norris, and J. R. Baker, Jr., "Detection and analysis of tumor fluorescence using a two-photon optical fiber probe," Biophys J 86, 3959-3965 (2004).
12. M. T. Myaing, J. Y. Ye, T. B. Norris, T. Thomas, J. R. Baker, W. J. Wadsworth, G. Bouwmans, J. C. Knight, and P. S. J. Russell, "Enhanced two-photon biosensing with double-clad photonic crystal fibers," Optics Letters 28, 1224-1226 (2003).
13. Y. C. Chang, J. Y. Ye, T. Thomas, Y. Chen, J. R. Baker, and T. B. Norris, "Two-photon fluorescence correlation spectroscopy through a dual-clad optical fiber," Opt. Express 16, 12640-12649 (2008).
14. T. P. Thomas, J. Y. Ye, Y. C. Chang, A. Kotlyar, Z. Cao, I. J. Majoros, T. B. Norris, and J. R. Baker, "Investigation of tumor cell targeting of a dendrimer nanoparticle using a double-clad optical fiber probe," J. Biomed. Opt. 13, 6 (2008).
15. T. P. Thomas, M. T. Myaing, J. Y. Ye, K. Candido, A. Kotlyar, J. Beals, P. Cao, B. Keszler, A. K. Patri, T. B. Norris, and J. R. Baker, "Detection and analysis of tumor fluorescence using a two-photon optical fiber probe," Biophysical Journal 86, 3959-3965 (2004).
16. E. R. Tkaczyk, A. H. Tkaczyk, S. Katnik, J. Y. Ye, K. E. Luker, G. D. Luker, A. Myc, J. R. Baker, Jr., and T. B. Norris, "Extended cavity laser enhanced two-photon flow cytometry," J Biomed Opt 13, 041319 (2008).
17. C. F. Zhong, "Quantitative Two-photon Flow Cytometry - in vitro and vivo," Ph.D. Thesis, University of Michigan, Ann Arbor (2006).
18. R. Weissleder, and V. Ntziachristos, "Shedding light onto live molecular targets," Nat Med 9, 123-128 (2003).
19. I. Georgakoudi, N. Solban, J. Novak, W. L. Rice, X. Wei, T. Hasan, and C. P. Lin, "In vivo flow cytometry: a new method for enumerating circulating cancer cells," Cancer Res 64, 5044-5047 (2004).