Proinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived light

European Journal of Medical Research

Volumn 14, Issue 4, 2009, Pages 147-156

  Celik, S ^a   Shankar, V ^a   Richter, A ^a   Hippe, H J ^a   Akhavanpoor, M ^a   Bea, E ^a   Erbel, C ^a   Urban, S ^a   Blank, N ^a   Wambsganss, N ^a   Katus, H A ^a   Dengler, Thomas J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Endothelial cells; Inflammation; LIGHT

Indexed keywords

GAMMA INTERFERON; HERPESVIRUS ENTRY MEDIATOR LIGAND; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; IONOMYCIN; MESSENGER RNA; METALLOPROTEINASE; PHORBOL 13 ACETATE 12 MYRISTATE; THROMBOPLASTIN;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL SPECIFICITY; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME REGULATION; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; MACROPHAGE; MALE; MOLECULAR WEIGHT; MONOCYTE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION; THROMBOSIS; VASCULAR ENDOTHELIUM;

EID: 65349121295     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-14-4-147     Document Type: Article

References (24)

1. Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword.Nat Rev Immunol. 2003 Sep; 3(9):745-56
2. Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, Chen SF, Hsieh SL, Nagata S, Ni J, Chen L. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response J Immunol. 2000 Apr 15;164(8):4105-10
3. Scholz H, Sandberg W, Damas JK, Smith C, Andreassen AK, Gullestad L, Froland SS, Yndestad A, Aukrust P, Halvorsen B. Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis. Circulation. 2005;112:2121-2129.
4. Schneider K, Potter KG, Ware CF. Lymphotoxin and LIGHT signaling pathways and target genes.Immunol Rev. 2004 Dec;202:49-66. Review
5. Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest. 2006 Apr;116(4): 1045-51.
6. Lee WH, Kim SH, Lee Y, Lee BB, Kwon B, Song H, Kwon BS, Park JE. Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler Thromb Vasc Biol. 2001 Dec;21(12): 2004-10
7. Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P, Damas JK. Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes. Blood. 2006.
8. Celik S, Langer H, Stellos K, May AE, Shankar V, Kurz K, Katus HA, Gawaz MP, Dengler TJ. Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium. Thromb Haemost. 2007 Oct; 98(4):798-805
9. Ivandic BT, Spanuth E, Haase D, Lestin HG, Katus HA. Increased plasma concentrations of soluble CD40 ligand in acute coronary syndrome depend on in vitro platelet activationClin Chem. 2007 Jul;53(7):1231-4.
10. Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, Gimbrone MA, Jr. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol. 1986; 136:1680-1687.
11. Kluger MS, Johnson DR, Pober JS. Mechanism of sustained E-selectin expression in cultured human dermal microvascular endothelial cells. J Immunol. 1997;158:887-896.
12. Nawroth PP, Stern DM, Kisiel W, Bach R. Cellular requirements for tissue factor generation by bovine aortic endothelial cells in cultureThromb Res. 1985 Dec 1;40(5): 677-91
13. Arnett FC, Edworth SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheumatism 31:315-324
14. Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998;8:21-30.
15. Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest. 2006 Apr;116(4): 1045-51.
16. Kim WJ, Kang YJ, Koh EM, Ahn KS, Cha HS, Lee WH.LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9 in macrophages. Immunology. 2005 Feb;114(2):272-9
17. Aukrust P, Muller F, Ueland T, Berget T, Aaser E, Brunsvig A, Solum NO, Forfang K, Froland SS, Gullestad L. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. Circulation. 1999;100:614-620)
18. Garlichs CD, John S, Schmeisser A, Eskafi S, Stumpf C, Karl M, Goppelt-Struebe M, Schmieder R, Daniel WG. Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia. Circulation. 2001 Nov 13;104(20):2395-400
19. Marx N, Imhof A, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Maerz W, Hombach V, Koenig W. Effect of rosiglitazone treatment on soluble CD40L in patients with type 2 diabetes and coronary artery disease. Circulation. 2003 Apr 22;107(15):1954-7.
20. Granger SW, Butrovich KD, Houshmand P, Edwards WR, Ware CF.Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis J Immunol. 2001 Nov 1;167(9):5122-8
21. Contin C, Pitard V, Itai T, Nagata S, Moreau JF, Déchanet-Merville J. Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling. J Biol Chem. 2003 Aug 29;278(35):32801-9.
22. Zhai Y, Guo R, Hsu TL, Yu GL, Ni J, Kwon BS, Jiang GW, Lu J, Tan J, Ugustus M, Carter K, Rojas L, Zhu F, Lincoln C, Endress G, Xing L, Wang S, Oh KO, Gentz R, Ruben S, Lippman ME, Hsieh SL, Yang D. LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest. 1998 Sep 15;102(6):1142-51
23. Tellides G, Tereb DA, Kirkiles-Smith NC, Kim RW, Wilson JH, Schechner JS, Lorber MI, Pober JS.Interferon-gamma elicits arteriosclerosis in the absence of leukocytes.Nature. 2000 Jan 13;403(6766):207-11.
24. Dahl CP, Gullestad L, Fevang B, Holm AM, Landrø L, Vinge LE, Fiane AE, Sandberg WJ, Otterdal K, Frøland SS, Damås JK, Halvorsen B, Aukrust P, Oie E, Yndestad A. Increased expression of LIGHT/ TNFSF14 and its receptors in experimental and clinical heart failure. Eur J Heart Fail. 2008 Apr;10(4):352-9.