Investigation of the synthetic route to pepstatin analogues by SPPS using O-protected and O-unprotected statine as building blocks

Journal of Peptide Science

Volumn 15, Issue 4, 2009, Pages 272-277

  Cadicamo, Cosimo D ^a   Asante, Vivian ^a   Ammar, Morhaf Abu ^a   Borelli, Claudia ^b   Korting, Hans C ^b   Koksch, Beate ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

N Fmoc O TBS statine; O silylation; Pepstatin A; SPPS

Indexed keywords

3 HYDROXY 4 (9H FLUOREN 9 YLMETHYLOXYCARBONYL)AMINO 6 METHYLHEPTANOIC ACID; 3 TERT BUTYLDIMETHYLSILANOYLOXY 4 (9H FLUOREN 9 YLMETHYLOXYCARBONYL)AMINO 6 METHYLHEPTANOIC ACID; 4 HYDROXY 5 ISOBUTYL 1 (9H FLUOREN 9 YLMETHYLOXYCARBONYL)PYRROL 2(5H) ONE; 4 HYDROXY 5 ISOBUTYL 1 (9H FLUOREN 9 YLMETHYLOXYCARBONYL)PYRROLIDIN 2 ONE; 5 [[1 HYDROXY 4 METHYL 2 (9H FLUOREN 9 YLMETHYLOXYCARBONYL)AMINO]PENTYLIDENE] 2,2 DIMETHYL 1,3 DIOXANE 4,6 DIONE; ISOVALINYLVALYLLEUCYLSTATINYLALANYLSTATINE; PEPSTATIN DERIVATIVE; STATINE; TERT BUTYLDIMETHYLSILYLCHLORIDE; UNCLASSIFIED DRUG; AMINO ACID; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLUORENE DERIVATIVE; N(ALPHA) FLUORENYLMETHYLOXYCARBONYLAMINO ACIDS; N(ALPHA)-FLUORENYLMETHYLOXYCARBONYLAMINO ACIDS; PEPSTATIN;

ACYLATION; ANALYTIC METHOD; ARTICLE; COUPLING FACTOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; PURIFICATION; SILYLATION; SOLID PHASE SYNTHESIS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

IVA;

AMINO ACID SEQUENCE; AMINO ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORENES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PEPSTATINS;

EID: 65349087279     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1111     Document Type: Article

References (19)

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