Scrapie-resistant sheep show certain coat colour characteristics

Genetics Research

Volumn 91, Issue 1, 2009, Pages 39-46

  Sawalha, Rami M ^a,d   Bell, L ^b   Brotherstone, S ^c   White, I ^c   Wilson, A J ^c   Villanueva, B ^a  

^a SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

^b Shetland Sheep Society   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ARTICLE; BREEDING; DISEASE RESISTANCE; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENETIC SELECTION; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; INFECTION CONTROL; INFECTION RESISTANCE; INFECTION SENSITIVITY; MALE; MAXIMUM LIKELIHOOD METHOD; MORPHOLOGY; NONHUMAN; SCRAPIE; SHEEP; SKIN COLOR; ANIMAL; DISEASE PREDISPOSITION; GENETICS; GENOTYPE; HAIR COLOR; PHENOTYPE;

ANIMALIA; OVIS ARIES;

ANIMALS; DISEASE SUSCEPTIBILITY; GENETIC VARIATION; GENOTYPE; HAIR COLOR; PHENOTYPE; SCRAPIE; SHEEP;

EID: 65249177232     PISSN: 00166723     EISSN: 14695073     Source Type: Journal    
DOI: 10.1017/S0016672308009968     Document Type: Article

References (30)

1. Agresti, A. (1996). An Introduction to Categorical Data Analysis, 2nd edn. New York: Wiley & Sons.
2. Arnold, M., Meek, C., Webb, C. R. & Hoinville, L. J. (2002). Assessing the efficacy of a ram-genotyping programme to reduce susceptibility to scrapie in Great Britain. Preventive Veterinary Medicine 56, 227-249.
3. Baylis, M., Chihota, C., Stevenson, E., Goldmann, W., Smith, A., Sivam, K., Tongue, S. & Gravenor, M. B. (2004). Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology 85, 2735-2740.
4. Bell, L., Goodman, T., Martin, J. H., Rosbotham, M. & Stockwell, C. (2005). A survey of scrapie PrP genotype results and their relationship with coat colour and hornedness in selected UK rare breed sheep. Proceedings of the British Society of Animal Science, p. 124.
5. Belt, P. B., Muileman, I. H., Schreuder, B. E., Bos-de Ruijter, J., Gielkens, A. L. & Smits, M. A. (1995). Identification of 5 allelic variants of the sheep PrP gene and their association with natural scrapie. Journal of General Virology 76, 509-517.
6. Beraldi, D., McRae, A. F., Gratten, J., Slate, J., Visscher, P. M. & Pemberton, J. M. (2006). Development of a linkage Map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries). Genetics 173, 1521-1537.
7. Goldmann, W., Hunter, N., Smith, G., Foster, J. & Hope, J. (1994). PrP genotype and agent effects in scrapie: Change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. Journal of General Virology 75, 989-995.
8. Gratten, J., Beraldi, D., Lowder, B. V., McRae, A. F., Visscher, P. M., Pemberton, J. M. & Slate, J. (2007). Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour polymorphism in a free-living population of Soay sheep. Proceedings of the Royal Society B-Biological Sciences 274, 619-626.
9. Gratten, J., Wilson, A. J., McRae, A. F., Beraldi, D., Visscher, P. M., Pemberton, J. M. & Slate, J. (2008). A localized negative genetic correlation constrains micro-evolution of coat color in wild sheep. Science 319, 318-320.
10. Hoekstra, H. E. & Nachman, M. W. (2003). Different genes underlie adaptive melanism in different populations of rock pocket mice. Molecular Ecology 12, 1185-1194.
11. Hunter, N., Foster, J. D., Goldmann, W., Stear, M. J., Hope, J. & Bostock, C. (1996). Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Archives of Virology 141, 809-824.
12. Jewell, P. A. (1971). The case for the preservation of rare breeds of domestic livestock. Veterinary Record 89, 524-527.
13. Klungland, H. & Våge, D. I. (2003). Pigmentary switches in domestic animal species. Melanocortin System 994, 331-338.
14. Lühken, G., Brandt, H. R., Buschmann, A., Groschup, M. H. & Erhardt, G. (2006). Microsatellite CTSBJ12 is located distal to the ovine prion protein gene on OAR13 and is not associated with scrapie susceptibility. Animal Genetics 37, 426-427.
15. McRae, A. F., McEwan, J. C., Dodds, K. G., Wilson, T., Crawford, A. M. & Slate, J. (2002). Linkage disequilibrium in domestic sheep. Genetics 160, 1113-1122.
16. Moorcroft, P. R., Albon, S. D., Pemberton, J. M., Stevenson, I. R. & Clutton-Brock, T. H. (1996). Density-dependent selection in a fluctuating ungulate population. Proceedings of the Royal Society B-Biological Sciences 263, 31-38.
17. Parsons, Y. M., Fleet, M. R. & Cooper, D. W. (1999a). Isolation of the ovine agouti coding sequence. Pigment Cell Research 12, 394-397.
18. Parsons, Y. M., Fleet, M. R. & Cooper, D. W. (1999b). The Agouti gene: A positional candidate for recessive self-colour pigmentation in the Australian merino. Australian Journal of Agricultural Research 50, 1099-1103.
19. Renieri, C., Pieramati, C., Olivieri, O., Trabalza Marinucci, M. & Micarelli, F. (1989). Frequencies of fleece colour in Upper Visso sheep. Small Ruminant Research 2, 175-180.
20. Renieri, C., Valbonesi, A., La Mannaa, V., Antonini, M. & Lauvergne, J. J. (2008). Inheritance of coat colour in Merino sheep. Small Ruminant Research 74, 23-29.
21. Roughsedge, T., Villanueva, B. & Woolliams, J. A. (2006). Determining the relationship between restorative potential and size of a gene bank to alleviate the risks inherent in a scrapie eradication breeding programme. Livestock Science 100, 231-241.
22. Ryder, M. L. (1976). Why should rare breeds of livestock be saved? International Zoo Yearbook 16, 244-249.
23. Sawalha, R. M., Brotherstone, S., Conington, J. & Villanueva, B. (2007). Lambs with scrapie susceptible genotypes have higher postnatal survival. PLoS One 2, e1236. doi:10.1371/journal.pone.0001236.
24. Sawalha, R. M., Brotherstone, S., Lambe, N. R. & Villanueva, B. (2008). Association of the prion protein gene with individual tissue weights in Scottish Blackface sheep. Journal of Animal Science 86, 1737-1746.
25. Sweeney, T. & Hanrahan, J. P. (2008). The evidence of associations between prion protein genotype and production, reproduction and health traits in sheep. Veterinary Research 39, 28.
26. Våge, D. I., Klungland, H., Lu, D. & Cone, R. D. (1999). Molecular and pharmacological characterization of dominant black coat color in sheep. Mammalian Genome 10, 39-43.
27. Våge, D. I., Fleet, M. R., Ponz, R., Olsen, R. T., Monteagudo, L. V., Tejedor, M. T., Arruga, M. V., Gagliardi, R., Postiglioni, A., Nattrass, G. S. & Klungland, H. (2003). Mapping and characterization of the dominant black colour locus in Sheep. Pigment Cell Research 16 693-697.
28. Voisey, J. & van Daal, A. (2002). Agouti: From mouse to man, from skin to fat. Pigment Cell Research 15, 10-18.
29. Warner, R. G., Morris, D. & Dawson, M. (2006). PrP genotype progression in flocks participating in the National Scrapie Plan for Great Britain. Veterinary Record 159, 473-479.
30. vy/- mice: Ectopic expression of the agouti gene. FASEB Journal 8, 479-488.