Microseparation techniques for the study of the enantioselectivity of drug-plasma protein binding

Biomedical Chromatography

Volumn 23, Issue 3, 2009, Pages 225-238

  Escuder Gilabert, Laura ^a   Martínez Gómez, María Amparo ^a   Villanueva Camañas, Rosa María ^a   Sagrado, Salvador ^a   Medina Hernández, María José ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Allosteric effects; Enantiomer enantiomer interactions; Interspecies effect; Separation techniques; Stereoselective drug plasma protein binding

Indexed keywords

BIOCHEMISTRY; DRUG INTERACTIONS; ENANTIOSELECTIVITY; PROTEINS; STEREOSELECTIVITY;

ALLOSTERIC EFFECT; CHIRAL DRUGS; ENANTIOMER-ENANTIOMER INTERACTION; INTERSPECIES EFFECT; MICRO-SEPARATION; PLASMA PROTEIN BINDING; PROTEIN-BINDING; SEPARATION TECHNIQUES; STEREO-SELECTIVE; STEREOSELECTIVE DRUG-PLASMA PROTEIN BINDING;

ENANTIOMERS;

8 [3 METHOXY 4 (PHENYLSULFINYL)PHENYL]PYRAZOLO[1,5 A][1,3,5]TRIAZIN 4 OL; ACENOCOUMAROL; ALPRENOLOL; AMINOHYDANTOIN DERIVATIVE; BROMPHENIRAMINE; CARBENICILLIN; CHLORPHENIRAMINE; DIAZEPAM DERIVATIVE; DISOPYRAMIDE; HYDANTOIN DERIVATIVE; HYDROXYZINE; IBUPROFEN; INDOBUFEN; KETOPROFEN; LIPOPROTEIN; LORAZEPAM; MEFLOQUINE; NILVADIPINE; OROSOMUCOID; ORPHENADRINE; OXYBUTYNIN; PHENPROCOUMON; PLASMA PROTEIN; PROPRANOLOL; SERUM ALBUMIN; SULBENICILLIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; WARFARIN; ZOPICLONE;

ALLOSTERISM; BINDING AFFINITY; CHIRALITY; CHROMATOGRAPHY; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG SCREENING; ELECTROPHORESIS; ENANTIOMER; ENANTIOSELECTIVITY; EQUILIBRIUM DIALYSIS; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PHARMACODYNAMICS; PROTEIN IMMOBILIZATION; RACEMIC MIXTURE; REVIEW; SEPARATION TECHNIQUE; SPECIES DIFFERENCE; STEREOCHEMISTRY;

ANIMALIA;

EID: 65249166083     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1134     Document Type: Review

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