Tumor necrosis factor-α downregulates intestinal NHE8 expression by reducing basal promoter activity

American Journal of Physiology - Cell Physiology

Volumn 296, Issue 3, 2009, Pages

  Xu, Hua ^a   Chen, Huacong ^a,b   Dong, Jiali ^a   Li, Jing ^a   Chen, Rongji ^a   Uno, Jennifer K ^a   Ghishan, Fayez K ^a,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b WELLESLEY COLLEGE   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Intestine; Sodium hydrogen exchanger 8; Trinitrobenzene sulfonic acid colitis

Indexed keywords

DACTINOMYCIN; GENOMIC DNA; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MESSENGER RNA; SODIUM PROTON EXCHANGE PROTEIN; TRANSCRIPTION FACTOR SP3; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; NHE8 PROTEIN, RAT; NUCLEIC ACID SYNTHESIS INHIBITOR; RECOMBINANT PROTEIN; SLC9A8 PROTEIN, HUMAN; SP3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CELL STRAIN CACO 2; COLITIS; CONTROLLED STUDY; DIARRHEA; DOWN REGULATION; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE; JEJUNUM MUCOSA; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; GENETICS; INTESTINE MUCOSA; JEJUNUM; METABOLISM; MICROVILLUS; MOLECULAR GENETICS; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME; TRANSCRIPTION INITIATION SITE;

RATTUS;

ANIMALS; BASE SEQUENCE; CACO-2 CELLS; CLONING, MOLECULAR; COLITIS; DIARRHEA; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HUMANS; INTESTINAL MUCOSA; JEJUNUM; LIPOPOLYSACCHARIDES; MALE; MICROVILLI; MOLECULAR SEQUENCE DATA; NUCLEIC ACID SYNTHESIS INHIBITORS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RNA, MESSENGER; SODIUM-HYDROGEN ANTIPORTER; SP3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65249136545     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00482.2008     Document Type: Article

References (53)

1. Amin MR, Malakooti J, Sandoval R, Dudeja PK, Ramaswamy K. IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1. Am J Physiol Cell Physiol 291: C887-C896, 2006.
2. + exchanger (NHE5) highly expressed in brain. J Biol Chem 274: 4383-4388, 1999.
3. + exchanger isoform 5 (NHE5) from human brain. J Biol Chem 274: 4377-4382, 1999.
4. Barmeyer C, Harren M, Schmitz H, Heinzel-Pleines U, Mankertz J, Seidler U, Horak I, Wiedenmann B, Fromm M, Schulzke JD. Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation. Am J Physiol Gastrointest Liver Physiol 286: G244-G252, 2004. (Pubitemid 38134035)
5. Bell SM, Schreiner CM, Schultheis PJ, Miller ML, Evans RL, Vorhees CV, Shull GE, Scott WJ. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am J Physiol Cell Physiol 276: C788-C795, 1999. (Pubitemid 29211306)
6. + exchanger isoform NHE-1 in rabbit kidney. Am J Physiol Renal Fluid Electrolyte Physiol 263: F833-F840, 1992.
7. Boivin GP, Schultheis PJ, Shull GE, Stemmermann GN. Variant form of diffuse corporal gastritis in NHE2 knockout mice. Comp Med 50: 511-515, 2000.
8. + exchanger isoform NHE4 and localization in rat hippocampus. Am J Physiol Cell Physiol 271: C1629-C1638, 1996.
9. + exchanger isoforms NHE2 and NHE4 in rat intestine and kidney. Am J Physiol Cell Physiol 273: C1496-C1505, 1997.
10. + exchanger: evidence that the cytoplasmic domain mediates hormonal regulation. Proc Natl Acad Sci USA 89: 6765-6769, 1992.
11. + exchanger isoform, NHE3. Am J Physiol Cell Physiol 269: C198-C206, 1995.
12. Castro M, Papadatou B, Baldassare M, Balli F, Barabino A, Barbera C, Barca S, Barera G, Bascietto F, Berni Canani R, Calacoci M, Campanozzi A, Castellucci G, Catassi C, Colombo M, Covoni MR, Cucchiara S, D'Altilia MR, De Angelis GL, De Virgilis S, Di Ciommo V, Fontana M, Guariso G, Knafelz D, Lambertini A, Licciardi S, Lionetti P, Liotta L, Lombardi G, Maestri L, Martelossi S, Mastella G, Oderda G, Perini R, Pesce F, Ravelli A, Roggero P, Romano C, Rotolo N, Rutigliano V, Scotta S, Sferlazzas C, Staiano A, Ventura A, Zaniboni MG. Inflammatory bowel disease in children and adolescents in Italy: data from the pediatric national IBD register (1996-2003). Inflamm Bowel Dis 14: 1246-1252, 2008.
13. + exchanger (NHE-2). Proc Natl Acad Sci USA 90: 3938-3942, 1993.
14. Collins JF, Xu H, Kiela PR, Zeng J, Ghishan FK. Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium. Am J Physiol Cell Physiol 273: C1937-C1946, 1997. (Pubitemid 28079536)
15. + exchanger NHE1. Biochim Biophys Acta 1172: 343-345, 1993.
16. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 44: 1041-1045, 1993.
17. + exchanger. J Biol Chem 280: 12781-12789, 2005.
18. Goyal S, Mentone S, Aronson PS. Immunolocalization of NHE8 in rat kidney. Am J Physiol Renal Physiol 288: F530-F538, 2005. (Pubitemid 40279459)
19. + exchanger isoform NHE8. Am J Physiol Renal Physiol 284: F467-F473, 2003.
20. + exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 287: G370-G378, 2004.
21. + exchanger (NHE-2). Biochim Biophys Acta 1150: 199-202, 1993.
22. Hoogerwerf WA, Tsao SC, Devuyst O, Levine SA, Yun CH, Yip JW, Cohen ME, Wilson PD, Lazenby AJ, Tse CM, Donowitz M. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol Gastrointest Liver Physiol 270: G29-G41, 1996. (Pubitemid 26056808)
23. Ito R, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J, Imanishi J, Kita M, Ueda Y, Iwakura Y, Kataoka K, Okanoue T, Mazda O. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clin Exp Immunol 146: 330-338, 2006. (Pubitemid 44581349)
24. Latinne D, Fiasse R. New insights into the cellular immunology of the intestine in relation to the pathophysiology of inflammatory bowel diseases. Acta Gastroenterol Belg 69: 393-405, 2006. (Pubitemid 46255108)
25. + exchanger has no apparent effect on diarrheal state of NHE3- deficient mice. Am J Physiol Gastrointest Liver Physiol 281: G1385-G1396, 2001.
26. + exchangers stably expressed in a fibroblast cell line. J Biol Chem 268: 25527-25535, 1993.
27. Liang YC, Liu HJ, Chen SH, Chen CC, Chou LS, Tsai LH. Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: roles of nitric oxide and prostaglandin E2. World J Gastroenterol 11: 357-361, 2005.
28. Ludwiczek O, Kaser A, Novick D, Dinarello CA, Rubinstein M, Tilg H. Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease. Eur Cytokine Netw 16: 27-33, 2005. (Pubitemid 40478073)
29. MacRae VE, Wong SC, Farquharson C, Ahmed SF. Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases. Int J Mol Med 18: 1011-1018, 2006.
30. + exchanger NHE2. Am J Physiol Gastrointest Liver Physiol 277: G383-G390, 1999.
31. Mathan VI, Penny GR, Mathan MM, Rowley D. Bacterial lipopolysaccharide- induced intestinal microvascular lesions leading to acute diarrhea. J Clin Invest 82: 1714-1721, 1988. (Pubitemid 19007778)
32. Miyazaki E, Sakaguchi M, Wakabayashi S, Shigekawa M, Mihara K. NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. J Biol Chem 276: 49221-49227, 2001. (Pubitemid 37370631)
33. +-ATPase. J Clin Invest 110: 1739-1747, 2002.
34. + exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem 280: 1561-1572, 2005.
35. + exchanger localized to the trans-Golgi network. J Biol Chem 276: 17387-17394, 2001.
36. O'Morain CA. Does nutritional therapy in inflammatory bowel disease have a primary or an adjunctive role? Scand J Gastroenterol Suppl 172: 29-34, 1990.
37. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267: 9331-9339, 1992.
38. Rijnierse A, Koster AS, Nijkamp FP, Kraneveld AD. TNF-alpha is crucial for the development of mast cell-dependent colitis in mice. Am J Physiol Gastrointest Liver Physiol 291: G969-G976, 2006.
39. + exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells. Am J Physiol Cell Physiol 280: C1224-C1232, 2001.
40. Ruemmele FM, Beaulieu JF, Dionne S, Levy E, Seidman EG, Cerf-Bensussan N, Lentze MJ. Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha. Gut 51: 842-848, 2002. (Pubitemid 35408606)
41. + antiporter. Cell 56: 271-280, 1989.
42. + exchanger. Nat Genet 19: 282-285, 1998.
43. Spoettl T, Hausmann M, Klebl F, Dirmeier A, Klump B, Hoffmann J, Herfarth H, Timmer A, Rogler G. Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients. Inflamm Bowel Dis 13: 727-732, 2007. (Pubitemid 46909987)
44. Sundaram U, West AB. Effect of chronic inflammation on electrolyte transport in rabbit ileal villus and crypt cells. Am J Physiol Gastrointest Liver Physiol 272: G732-G741, 1997. (Pubitemid 27216520)
45. Theodorou V, Chovet M, Eutamene H, Fargeau H, Dassaud M, Toulouse M, Bihoreau C, Roman FJ, Bueno L. Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action. Gut 51: 522-528, 2002.
46. Torimoto K, Sato N, Okubo M, Yagihashi A, Wada Y, Hara I, Hayasaka H, Kikuchi K. Development of multiple necrotizing enteritis induced by a tumor necrosis factor-like cytokine from lipopolysaccharide-stimulated peritoneal macrophages in rats. Am J Pathol 137: 1103-1111, 1990.
47. + exchanger. EMBO J 10: 1957-1967, 1991.
48. + exchanger from Caco-2 cells, a human intestinal cell line. Am J Physiol Gastrointest Liver Physiol 261: G229-G238, 1991.
49. + exchanger knockout model of congenital diarrhea. J Biol Chem 277: 49036-49046, 2002.
50. Xu H, Chen H, Dong J, Lynch R, Ghishan FK. Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8). Cell Physiol Biochem 21: 109-116, 2008.
51. Xu H, Chen R, Ghishan FK. Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8. Am J Physiol Gastrointest Liver Physiol 289: G36-G41, 2005. (Pubitemid 40944221)
52. Xu H, Inouye M, Hines ER, Collins JF, Ghishan FK. Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb. Am J Physiol Cell Physiol 284: C1262-C1271, 2003. (Pubitemid 36457407)
53. + exchanger gene family: structure and function studies. Am J Physiol Gastrointest Liver Physiol 269: G1-G11, 1995.