Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3067-3071

  Tanifum, Eric A ^a   Kots, Alexander Y ^b   Choi, Byung Kwon ^b   Murad, Ferid ^b   Gilbertson, Scott R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

cGMP; Diarrhea; Pyridopyrimidine; STa

Indexed keywords

CYCLIC GMP; CYCLIC NUCLEOTIDE; PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; ESCHERICHIA COLI; NONHUMAN; NUCLEOTIDE METABOLISM; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BACTERIAL TOXINS; CELL LINE, TUMOR; CYCLIC GMP; ENTEROTOXINS; ESCHERICHIA COLI; GUANYLATE CYCLASE; HUMANS; PYRIMIDINES; RECEPTORS, PEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI;

EID: 65149102947     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.024     Document Type: Article

References (11)

1. Morris S.S., Black R.E., and Tomaskovic L. Int. J. Epidemiol. 32 (2003) 1041
2. Qadri F., Svennerholm A.M., Faruque A.S., and Sack R.B. Clin. Microbiol. Rev. 12 (2005) 465
3. Field M., Graf L.H., Laird W.J., and Smith P.L. Proc. Natl. Acad. Sci. U.S.A. 75 (1978) 2800
4. Hughes J.M., Murad F., Chang B., and Guerrant R.L. Nature 271 (1978) 755
5. Vaandrager A.B. Mol. Cell Biochem. 230 (2002) 73
6. Kots A.Y., Choi B.-K., Jimenez M.E., Warren C.A., Gilbertson S.R., Guerrant R.L., and Murad F. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 8440
7. CLog P values were calculated using ACD/ChemSketch software.
8. Hantzsch A. Chem. Ber. 14 (1881) 1637
9. Agarwal A., and Chauhan P.M.S. Synth. Commun. 34 (2004) 8440
10. Agarwal A., Ashutosh R., Goyal N., Chauhan P.M., and Gupta S. Bioorg. Med. Chem. 13 (2005) 6678
11. Manpadi M., Uglinskii P.Y., Rastogi S.K., Cotter K.M., Wong Y.-S.C., Anderson L.A., Ortega A.J., Van Slambrouck S., Steelant W.F.A., Rogelj S., Tongwa P., Antipin M.Y., Magedov I.V., and Kornienko A. Org. Biomol. Chem. 5 (2007) 3865