Exposure to ethyl carbamate in alcohol-drinking and nondrinking adults and its reduction by simple charcoal filtration

Food Control

Volumn 20, Issue 10, 2009, Pages 946-952

  Park, Sae Rom ^a   Ha, Sang Do ^b   Yoon, Ji Ho ^a   Lee, Sung Yong ^a   Hong, Kwon Pyo ^a   Lee, Eun Hye ^a   Yeom, Hye Jung ^a   Yoon, Nam Gyoon ^a   Bae, Dong Ho ^a  

^a Konkuk University   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Alcohol drinking; Charcoal filtration; Ethyl carbamate; Exposure assessment

Indexed keywords

EID: 65049090904     PISSN: 09567135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodcont.2009.02.006     Document Type: Article

References (35)

1. AOAC. AOAC Official Method 994.07: Ethyl carbamate in alcoholic beverages and soy sauce. In: Association of Official Analytical Communities (Ed). AOAC official method of analysis. 17th ed. (2000), AOAC International, Gaithersburg, MD 14-15
2. Arena M.E., Saguir M.C., and Nadra M. Arginine, citrulline and ornithine metabolism by lactic acid bacteria. International Journal of Food Microbiology 52 (1999) 155-161
3. Aresta M., Boscolo M., and Franco D.W. Copper (II) catalysis in cyanide conversion into ethyl carbamate in sprits and relevant reactions. Journal of Agricultural and Food Chemistry 49 (2001) 2819-2824
4. Battaglia R., Conacher H.B.S., and Page B.D. Ethyl carbamate (urethane) in alcoholic beverages and foods. Food Additives and Contaminants 4 (2001) 477-496
5. Brumley W.C., Canas B.J., Perfetti G.A., Mossoba M.M., Sphon J.A., and Corneliussen P.E. Detection of ethyl carbamate in whisky, sherry, port and wine by gas chromatography/tandem mass spectrometer. Analytical Chemistry 60 (1988) 975-978
6. California Environmental Protection Agency. Proposition 65 status report safe harbor levels: No significant risk levels for carcinogens and maximum allowable dose levels for chemicals causing reproductive toxicity (2004), California Environmental Protection Agency, CA, USA
7. Canas B.J., Harvey D.C., Robinson L.R., Sullivan M.P., Joe F.L., and Diachenko G.W. Ethyl carbamate levels in selected foods and beverages. Journal of AOAC International 72 (1989) 873-876
8. Cha S.W., Lee H.J., Cho M.H., Lee M.H., Koh W.S., Han S.S., et al. Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice. Toxicology Letters 119 (2001) 173-181
9. Foulke J. E. (1993). USFDA/CFSAN consumer report. Urethane in alcoholic beverages under investigation.
10. Hasegawa Y., Nakamura Y., Tonogai Y., Terasawa S., Ito Y., and Chiyama M. Determination of ethyl carbamate in various fermented foods by selected ion monitoring. Journal of Food Protection 53 (1990) 1058-1061
11. Herbert P., Santos L., Bastos M., Barros P., and Alives A. New HPLC method to determine ethyl carbamate in alcoholic beverages using fluorescence detection. Journal of Food Science 67 (2002) 1616-1620
12. Hoffler U., Dixon D., Peddada S., and Ghanayem B.I. Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice. Mutation Research 572 (2005) 58-72
13. Hoffler U., El-Masri H.A., and Ghanayem B.I. Cytochrome P450 2E1 (CYP2E1) is the principle enzyme responsible for urethane metabolism: Comparative studies using CYP2E1-null and wild-type mice. The Journal of Pharmacology and Experimental Therapeutics 305 (2003) 557-564
14. Hong K.P., Kang Y.S., Jung D.C., Park S.R., Yoon J.H., Lee S.Y., et al. Exposure to ethyl carbamate by consumption of alcoholic beverages imported in Korea. Food Science and Biotechnology 16 (2007) 975-980
15. HSDB (Hazardous Substances Databank). National toxicology information program (1993), US Department of Health and Human Services, Washington, DC, USA
16. IARC (International Agency for Research on Cancer). (2007). IARC monographs on the evaluation of the carcinogenic risk of chemicals to man (Vol. 7, p. 111).
17. IRIS. Integrated Risk Information System on Ethyl Carbamate (1999), US Environmental Protection Agency. National Center for Environmental Assessment, Office of Research and Development, Washington, DC, USA
18. KATS (2004). Korean Agency for Technology and Standards. Gwacheon, Korea.
19. Kim L.Y., Koh L.E., Chung H.J., and Kwon H.J. Determination of ethyl carbamate in some fermented Korean foods and beverages. Food Additives and Contaminants 17 (2000) 469-475
20. KNHANES III. The third Korea national health and nutrition examination survey (2005), Ministry of Health and Welfare, Seoul, Korea
21. Koh E.M., and Kwon H.J. Determination of fermentation specific carcinogen, ethyl carbamate, in kimchi. Korean Journal of Food Science and Technology 28 (1996) 421-429
22. Korea National Statistical Office. Social statistical survey (2006), Korea National Statistical Office, Daejeon, Korea
23. Lachenmeier D.W., Nerlich U., and Kuballa T. Automated determination of ethyl carbamate in stone-fruit spirits using head space solid-phase microextraction and gas chromatography-tandem mass spectrometry. Journal of Chromatography A 1 (2006) 116-120
24. Matsudo T., Aoki K., Fokuta N., Sasaki M., and Uchida K. Determination of ethyl carbamate in soy sauce and its possible precursor. Journal of Agricultural and Food Chemistry 41 (1993) 352-356
25. Mirvish S.S. The carcinogenic action and metabolism of urethane and N-hydroxyurethane. Advances in Cancer Research 11 (1968) 1-42
26. Ministry of Health and Welfare. Korean health and nutrition survey and the report (2005), Ministry of Health and Welfare, Gwacheon, Republic of Korea
27. Ough C.S. Ethyl carbamate in fermented beverages and food. Naturally occurring ethyl carbamate. Journal of Agricultural and Food Chemistry 24 (1976) 323-327
28. Ough C.S. Ethyl carbamate in fermented beverages and foods. II. Possible formation of ethyl carbamate from diethyl dicarbonate addition to wine. Journal of Agricultural and Food Chemistry 24 (1976) 328-331
29. Park K.K., Liem A., Stewart B.C., and Miller J.A. Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and metabolite of vinyl carbamate and ethyl carbamate (urethane). Carcinogenesis 14 (1993) 441-450
30. Rodriks J.V. Origins of risk assessment in food safety decision making. Journal of the American College of Toxicology 7 (1988) 539-542
31. Schlatter J., and Lutz W.K. The carcinogenic potential of ethyl carbamate (urethane): Risk assessment at human dietary exposure levels. Food and Chemical Toxicology 28 (1990) 205-211
32. Stevens D.F., and Ough C.S. Ethyl carbamate formation: Reaction of urea and citrulline with ethanol in wine under low to normal temperature conditions. American Journal of Enology and Viticulture 44 (1993) 309-312
33. Tomisawa M., Suemizu H., Ohnishi Y., Maruyama C., Urano K., Usui T., et al. Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice. Toxicology Letters 142 (2003) 111-117
34. Uthurry C.A., Varela F., Colomo B., Lepe J.A.S., Lombardero J., and Garcia del H.J.R. Ethyl carbamate concentrations of typical Spanish red wines. Food Chemistry 88 (2004) 329-336
35. Walker G., Winterlin W., Fouda H., and Seiber J. Gas chromatographic analysis of urethane in wine. Journal of Agricultural and Food Chemistry 22 (1974) 944-947