The role of epigenetics in altered gene expression involved in GABAergic transmission in the cerebellum of schizophrenia patients

American Journal of Psychiatry

Volumn 166, Issue 4, 2009, Pages 493-

  Peedicayil, Jacob ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE; 4 AMINOBUTYRIC ACID;

AUTISM; AUTOPSY; CEREBELLUM; DISEASE PREDISPOSITION; EPIGENETICS; GABAERGIC TRANSMISSION; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; ISOENZYME ANALYSIS; LETTER; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA; GENETIC EPIGENESIS; GENETICS; METABOLISM; NOTE; PATHOPHYSIOLOGY; SYNAPTIC TRANSMISSION;

AUTISTIC DISORDER; CEREBELLUM; EPIGENESIS, GENETIC; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION; GLUTAMATE DECARBOXYLASE; HUMANS; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION;

EID: 64949203785     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2009.09010011     Document Type: Letter

References (5)

1. Bullock WM, Cardon K, Bustillo J, Roberts RC, Perrone-Bizzozero NI: Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. Am J Psychiatry 2008; 165:1594-1603
2. Peedicayil J: The role of epigenetics in mental disorders. Indian J Med Res 2007; 126:105-111 (Pubitemid 350028041)
3. Abdolmaleky HM, Zhou JR, Thiagalingam S, Smith CL: Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics 2008; 9:1809-1823
4. Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M: Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics 2007; 2:29-36 (Pubitemid 46824847)
5. Peedicayil J, Thangavelu P: Purkinje cell loss in autism may involve epigenetic changes in the gene encoding GAD. Med Hypotheses 2008; 71:978