Purkinje cell loss in autism may involve epigenetic changes in the gene encoding GAD

Medical Hypotheses

Volumn 71, Issue 6, 2008, Pages 978-

  Peedicayil, Jacob ^a   Thangavelu, Premkumar ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; GLUTAMATE DECARBOXYLASE ANTIBODY;

AUTISM; BIPOLAR DISORDER; BRAIN CORTEX; CEREBELLUM; DNA METHYLATION; EPIGENETICS; HUMAN; LETTER; MENTAL DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PURKINJE CELL; SCHIZOPHRENIA;

AUTISTIC DISORDER; GLUTAMATE DECARBOXYLASE; HUMANS; PROMOTER REGIONS, GENETIC; PURKINJE CELLS;

EID: 53949104512     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.07.038     Document Type: Letter

References (5)

1. Rout U.K., and Dhossche D.M. A pathogenetic model of autism involving Purkinje cell loss through anti-GAD antibodies. Med Hypotheses 71 (2008) 218-221
2. Yip J., Soghomonian J.-.J., and Blatt G.J. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: Pathophysiological implications. Acta Neuropathol 113 (2007) 559-568
3. Peedicayil J. The role of epigenetics in mental disorders. Indian J Med Res 126 (2007) 105-111
4. Schanen N.C. Epigenetics of autism spectrum disorders. Hum Mol Genet 15 (2006) R138-R150
5. Costa E., Dong E., Grayson D.R., Guidotti A., Ruzicka W., and Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics 2 (2007) 29-36