Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1

Anticancer Research

Volumn 29, Issue 4, 2009, Pages 1255-1262

  Fang, Yuqiang ^a   Elahi, Abul ^a   Denley, Ryan C ^a   Rao, Pulivarthi H ^b   Brennan, Murray F ^c   Jhanwar, Suresh C ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c TEXAS CHILDREN S CANCER CENTER   (United States)

Author keywords

Cell cycle regulators; Malignant peripheral nerve sheath tumor; Metastasis; Molecular characterization; MPNST; Nm 23h1; Recurrence

Indexed keywords

ARTICLE; CELL CULTURE; CELL CYCLE REGULATION; CHROMOSOME ANALYSIS; CHROMOSOME LOSS; HUMAN; HUMAN CELL; KARYOTYPE; NERVE SHEATH TUMOR; NEUROFIBROMATOSIS; PERIPHERAL NERVE TUMOR; PRIORITY JOURNAL;

ADOLESCENT; BLOTTING, NORTHERN; CELL PROLIFERATION; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN; COMPARATIVE GENOMIC HYBRIDIZATION; FIBROBLASTS; GENES, NEUROFIBROMATOSIS 1; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LOSS OF HETEROZYGOSITY; NEOPLASM RECURRENCE, LOCAL; NERVE SHEATH NEOPLASMS; NEUROFIBROMATOSIS 1; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 64949185318     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Jhanwar SC, Chen Q, Li FP, Brennan MF and Woodruff JM: Cytogenetic analysis of soft tissue sarcomas: Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). Cancer Genet Cytogenet 72: 138-144, 1994.
2. Lazar A, Abruzzo LV, Pollock RE, Lee S and Czerniak B: Molecular diagnosis of sarcomas: Chromosomal translocations in sarcomas. Arch Pathol Lab Med 130: 1199-1207, 2006.
3. Ferner RE and Gutmann DH: International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis 1. Cancer Res 62: 1573-1577, 2002.
4. Mertens F and Lothe RA: Nervous system: Peripheral nerve sheath tumors. Atlas Genet Cytogenet Oncol Haematol May 2001. URL: http:// atlasgeneticsoncology.org/Tumors/PeriphNervSheatID5094.html
5. ISCN (1995): An International System for Human Cytogenetic Nomenclature. Mitelman F (ed.). Basel S. Karger, 1995.
6. Cigudosa IC, Rao PH, Calasanz MJ, Odero MD, Michaeli I, Jhanwar SC and Chaganti RSK: Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization. Blood 91: 3007-3010, 1998.
7. Rao PH, Cigudosa JC, Ning Y, Calasanz MJ, Iida S, Tagawa S, Michaeli J, Klein B, Dalla-Favera R, Jhanwar SC, Ried T and Chaganti RSK: Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma. Blood 92: 1743-1748, 1998.
8. Presti JC, Rao PH, Chen Q, Reuter VE, Li FP, Fair WR and Jhanwar SC: Histopathological, cytogenetic, and molecular characterization of renal cortical tumors. Cancer Res 51: 1544- 1552, 1991.
9. Cheng JQ, Jhanwar SC, Klein WM, Bell DW, Lee WC, Altomare DA, Nobori T, Olopade OI, Buckler AJ and Testa JR: pl6 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res 54: 5547-5551, 1994.
10. Antonescu CR, Leung DH, Dudas M, Ladanyi M, Brennan M, Woodruff JM and Cordon-Cardo C: Alterations of cell cycle regulators in localized synovial sarcoma: A multifactorial study with prognostic implications. Am J Pathol 156: 977-983, 2000.
11. Upadhyaya M, Han S, Consoli C, Majounie E, Horan M, Thomas NS, Potts C, Griffiths S, Ruggieri M, von Deimling A and Cooper DN: Characterization of the somatic mutational spectrum of neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors. Hum Mutat 23: 134- 146, 2004
12. De Raedt T, Maertens O, Chmara M, Brems H, Heyns I, Sciot R, Majounie E, Upadhyaya M, De Schepper S, Speleman F, Messiaen L, Vermeesch JR and Legius E: Somatic loss of wild-type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes Chromosomes Cancer 45: 893- 904, 2006.
13. Le LQ and Parada LF: Tumor microenvironment and neurofibromatosis type I: Connecting the GAPs. Oncogene 26: 4609-4616, 2007.
14. Heslin MJ, Cordon-Cardo C, Lewis JJ, Woodruff JM and Brennan MF: Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma. Cancer 83: 490-497, 1998.
15. Berner JM, S0rlie T, Mertens F, Hendriksen J, Sster G, Mandahl N, Brøgger A, Myklebost O and Lothe RA: Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: Studies of CDKN2A and other genes of the pRB pathway. Genes Chromosomes Cancer 26: 151-160, 1999.
16. Yoo J, Park SY, Kang SJ, Shim SI and Kim BK: Altered expression of Gl regulatory proteins in human soft tissue sarcomas. Arch Pathol Lab Med 126: 567-573, 2002.
17. Kourea HP, Orlow I, Scheithauer, Cordon-Cardo C and Woodruff JM: Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas. Am J Pathol 155: 1855-1860, 1999.
18. Legius E, Dierick H, Wu R, Hall BK, Marynen P, Cassiman JJ and Glover TW: TP53 mutations are frequent in malignant NF1 tumors. Genes Chromosomes Cancer 10: 250-255, 1994.
19. Lothe RA, Smith-S0rensen B, Hektoen M, Stenwig AE, Mandahl N, Sæter G and Mertens F: Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors. Genes Chromosomes Cancer 30: 202-206, 2001.
20. Hartsough MT and Steeg PS: Nm23-Hl: Genetic alterations and expression patterns in tumor metastasis. Am J Hum Genet 63: 6- 10,1998.
21. Gerdes H, Elahi A, Chen Q and Jhanwar SC: Characterization of newly established colorectal cancer cell lines: correlation between cytogenetic abnormalities and allelic deletions associated with multistep tumorigenesis. J Genet 79: 113-123, 2000.
22. Horak CE, Mendoza A, Vega-Valle E, Albaugh M, Graff-Cherry C, McDermott WG, Hua E, Merino MJ, Steinberg SM, Khanna C and Steeg PS: Nm23-Hl suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. Cancer Res 67: 11751-11759, 2007.
23. Hartsough MT, Clare SE, Mair M, Elkahloun AG, Sgroi D, Osborne K, Clark G and Steeg PS: Elevation of breast carcinoma / metastasis suppressor gene expression and reduced motility by DNA methylation inhibition. Cancer Res 61: 2320-2327, 2001.
24. Huang CS, Shih MK, Chuang CH and Hu ML: Lycopene inhibits cell migration and invasion and upregulates Nm23-Hl in a highly invasive hepatocarcinoma, SK-Hep-1 cells. J Nutr 755:2119-2123,2005.