Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-11C-methoxy]donepezil

NeuroImage

Volumn 46, Issue 3, 2009, Pages 616-623

  Hiraoka, Kotaro ^a   Okamura, Nobuyuki ^a   Funaki, Yoshihito ^b   Watanuki, Shoichi ^b   Tashiro, Manabu ^b   Kato, Motohisa ^a   Hayashi, Akiko ^a   Hosokai, Yoshiyuki ^a   Yamasaki, Hiroshi ^a   Fujii, Toshikatsu ^a   Mori, Etsuro ^a   Yanai, Kazuhiko ^a   Watabe, Hiroshi ^c  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Acetylcholinesterase; Acetylcholinesterase inhibitor; Donepezil; Positron emission tomography (PET)

Indexed keywords

ACETYLCHOLINESTERASE; CARBON 11; DONEPEZIL;

ADULT; AGED; ARTICLE; BRAIN MAPPING; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; FEMALE; FRONTAL LOBE; HUMAN; HUMAN EXPERIMENT; IMAGE RECONSTRUCTION; ISOTOPE LABELING; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; QUANTITATIVE ANALYSIS; THALAMUS;

ACETYLCHOLINESTERASE; AGED; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BRAIN; FEMALE; HUMANS; INDANS; MALE; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PROTEIN INTERACTION MAPPING;

EID: 64949182053     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2009.03.006     Document Type: Article

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