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Type II protein C deficiency: Identification and molecular modeling of two natural mutants with low anticoagulants and normal amidolytic activity
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The 2.8 A crystal structure of Gla-domainless activated protein C
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Three missense mutations in the protein C heavy chain causing type 1 and type II protein C deficiency
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A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va
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Genetic characterization of protein C deficiency In Japanese subjects using a rapid and nonradioactive method for single-strand conformational polymorphism analysis and a model building
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Defective sorting to secretory vesicles in trans-golgi network is partly responsible for protein C deficiency. Molecular mechanisms of impaired secretion of abnormal protein C R169W, R352W and G376D
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Naito M, Mimuro J, Endo H, et al. Defective sorting to secretory vesicles in trans-golgi network is partly responsible for protein C deficiency. Molecular mechanisms of impaired secretion of abnormal protein C R169W, R352W and G376D. Circulation Res 2003; 92: 865-872.
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Impaired Secretion of the elongated mutant of protein C (protein C- Nagoya). Molecular and cellular basis for hereditary protein C deficiency
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Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant
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Humphries S, Temple A, Lane A, et al. Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant. Thromb Haemost 1996; 75: 567-572.
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Recognition site directing vitamin K-dependent gamma-car-boxylation resides on the propeptide of factor IX
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Characterization of a cDna coding for human factor VII
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