Insulin-like Growth Factor-I (IGF-I) serum concentrations in depressed patients: Relationship to saliva cortisol and changes during antidepressant treatment

Pharmacopsychiatry

Volumn 42, Issue 1, 2009, Pages 23-28

  Weber Hamann, B ^a   Blum, W F ^b,c   Kratzsch, J ^d   Gilles, M ^a   Heuser, I ^a,e   Deuschle, M ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b LILLY DEUTSCHLAND GMBH   (Germany)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

^d UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; HYDROCORTISONE; LORAZEPAM; PAROXETINE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; ZOLPIDEM; ANTIDEPRESSANT AGENT;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE BLIND PROCEDURE; FEMALE; HORMONAL REGULATION; HUMAN; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; OPEN STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SALIVA LEVEL; ANALYSIS OF VARIANCE; BLOOD; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; METHODOLOGY; MIDDLE AGED; SALIVA;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYDROCORTISONE; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; SALIVA;

EID: 64749110512     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0028-1085442     Document Type: Article

References (42)

1. Bang P, Degerblad M, Thoren M et al. Insulin-like growth factor (IGF) I and II and IGF binding protein (IGFBP) 1, 2 and 3 in serum from patients with Cushing's syndrome. Acta Endocrinol (Copenh) 1993 ; 128 : 397-404
2. Blum WF, Albertsson-Wikland K, Rosberg S et al. Serum levels of insulinlike growth factor 1 and IGF binding protein 3 refl ect spontaneous growth hormone secretion. J Clin Endocrinol Metab 1 993; 7 6: 1 610- 1 616
3. Blum WF, Breier BH. Radioimmunoassays for IGFs and IGFBPs. Growth Regul 1994 ; 4 (Suppl 1) : 11-19
4. Blum WF, Ranke MB, Kietzmann K et al. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab 1990 ; 70 : 1292-1298
5. Bunn RC, Fowlkes JL. Insulin-like growth factor binding protein proteolysis . Trends Endocrin Metab 2003 ; 14 : 176-181
6. Contreras F, Navarro MA, Menchon JM et al. Growth hormone response to growth hormone releasing hormone in nondelusional and delusional depression and healthy controls. Psychological Medicine 1996 ; 26 : 301-307 (Pubitemid 26075203)
7. Deijen JB, Boer H de, Veen EA van der. Cognitive changes during growth hormone replacement in adult men. Psychoneuroendocrinology 1998 ; 23 : 45-55
8. Deuschle M, Blum WF, Strasburger CJ et al. Insulin-like growth factor- I plasma concentrations are increased in depressed patients. Psychoneuroendocrinology 1997 ; 22 : 493-503
9. Deuschle M, Hamann B, Meichel C et al. Antidepressive treatment with amitriptyline and paroxetine: effects on saliva cortisol concentrations. J Clin Psychopharmacol 2003 ; 23 : 201-205
10. Deuschle M, Krumm B, Bindeballe N et al. Open-label non-randomized versus double-blind randomized antidepressive treatment: what are the advantages of clinical decision over randomization. Pharmacopsychiatry 2004 ; 37 : 299-302
11. Deuschle M, Luppa P, Hamann B et al. Increased concentration of corticostreroid- binding globulin due to antidepressant treatment with amitriptyline, but not paroxetine. J Psychiatr Res 2003 ; 37 : 85-87
12. Franz B, Buysse DJ, Cherry CR et al. Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication . J Psychiatric Res 1999 ; 33 : 121-127
13. Henn FA, Vollmayr B. Neurogenesis and depression: etiology or epiphenomenon? Biol Psychiatry 2004 ; 56 : 146-150
14. Hoshaw BA, Malberg JE, Lucki I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res 2005 ; 1037 : 204-208
15. Janssen JA, Stolk RP, Pols HA et al. Serum free IGF-I, total IGF-I, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroid levels. J Clin Endocrinol Metab 1998 ; 48 : 471-478
16. Janssen JA, Jacobs ML, Derkx FH et al. Free and total insulin-like growth factor (IGF-I), IGF binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997 ; 82 : 2809-2815
17. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995 ; 16 : 3-34
18. Kopf D, Wesphal S, Luley CW et al. Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism and antidepressant treatment. J Clin Psychopharmacol 2004 ; 24 : 527-531
19. LeRoith D. The insulin-like growth factor system. Experimental Diab Res 2003 ; 4 : 205-212
20. Lesch KP, Rupprecht R, M ü ller U et al. Insulin-like growth factor I in depressed patients and controls. Acta Psychiatrica Scandinavica 1988 ; 78 : 684-688
21. Lesch KP, Laux G, Erb A et al. Growth hormone (GH) and prolactin responses after GH-releasing hormone in major depressive disorder: relationship to somatomedin C levels and dexamethasone suppressibility of cortisol. Psychoneuroendocrinology 1988 ; 13 : 255-263
22. Magiakou MA, Mastorakos G, Gomez MT et al. Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing ' s disease before and after surgical cure. J Clin Endocrinol Metab 1994 ; 78 : 131-137
23. Mahajan T, Crown A, Checkley S et al. Atypical depression in growth hormone deficient adults, and the beneficial effects of growth hormone treatment on depression and quality of life. Eur J Endocrinology 2004 ; 151 : 325-332
24. Malberg JE, Platt B, Rizzo SJ et al. Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects. Neuropsychopharmacology 2007 Mar 7, (epub ahead of print)
25. MacMillan CV, Bradley C, Gibney J et al. Psychological effects of withdrawal of growth hormone therapy from adults with growth hormone deficiency. Clin Endocrinology 2003 ; 59 : 467-475 (Pubitemid 37188177)
26. Nam SY, Lee EJ, Kim KR et al. Effect of obesity on total and free insulinlike growth factor (IGF)-1 and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes Relat Metab Disord 1997 ; 21 : 355-359
27. Nass R, Thorner MO. Impact of GH-cortisol ratio on the age-dependent changes in body composition. Growth Horm IGF Res 2002 ; 12 : 147-161
28. Rosmond R, Dallman MF, Bjorntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 1998 ; 83 : 1853-1859
29. Rupprecht R, Rupprecht C, Rupprecht M et al. Effect of glucocorticoids on the regulation of the hypothalamic-pituitary-somatotropic system in depression. J Affective Disord 1989 ; 17 : 9-16
30. Schneider HJ, Pagotto U, Stalla GK. Central effects of somatotropic system . Eur J Endocrinology 2003 ; 149 : 377-392
31. Siever LJ, Trestman RL, Coccaro EF. The growth hormone response to clonidine in acute and remitted depressed male patients. Neuropsychopharmacology 1992 ; 6 : 165-177
32. Smink JJ, Gresnigt MG, Hamers N et al. Short-term glucocorticoid treatment of prepubertal mice decreases growth and IGF-I expression in the growth plate. J Endocrinol 2003 ; 177 : 381-388
33. Stewart PM, Toogood AA, Tomlinson JW. Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle. Horm Res 2001 ; 56 (Suppl 1) : 1-6
34. Takahashi M, Sawayama E, Sawayama T et al. Reversible paroxetineinduced symptomatic hypothyroidism. Pharmacopsychiatry 2007 ; 40 : 201-202
35. Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocrinology Review 1994 ; 15 : 80-101
36. Tichomirowa MA, Keck ME, Schneider HJ et al. Endocrine disturbances in depression. J Endocrinol Invest 2005 ; 28 : 89-99
37. Wajchenberg BL, Liberman B, Giannella ND et al. Growth hormone axis in Cushing's syndrome. Horm Res 1996 ; 45 : 99-107
38. Wakeno M, Okugawa G, Takekita Y et al. Delirium associated with paroxetine in an elderly depressive patient: a case report. Pharmacopsychiatry 2007 ; 40 : 199-200
39. Watson S, Porter RJ, Young AH. Effect of hydrocortisone on the pituitary response to growth hormone releasing hormone. Psychopharmacology 2000 ; 152 : 40-46
40. Weber-Hamann B, Hentschel F, Kniest A et al. Hypercortisolemic depression is associated with increased intra-abdominal fat. Psychosom Med 2002 ; 64 : 274-277
41. Zenker S, Haverkamp F, Klingm ü ller D. Growth hormone deficiency in pituitary disease: relationship to depression, apathy and somatic complaints . Eur J Endocrinology 2002 ; 147 : 165-171
42. Zhou X, Loke KY, Pillai CC et al. IGFs and IGF- binding proteins in short children with steroid-dependent nephrotic syndrome on chronic glucocorticoids: changes with 1 year exogenous GH. Eur J Endocrinol 2001 ; 144 : 237-243