Modularity of endpoint force patterns evoked using intraspinal microstimulation in treadmill trained and/or neurotrophin-treated chronic spinal cats

Journal of Neurophysiology

Volumn 101, Issue 3, 2009, Pages 1309-1320

  Boyce, Vanessa S ^a   Lemay, Michel A ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN; NERVE GROWTH FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAM; EXPERIMENTAL CAT; FEMALE; FIBROBLAST; GASTROCNEMIUS MUSCLE; HINDLIMB; LOCOMOTION; LUMBAR SPINAL CORD; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; TIBIALIS ANTERIOR MUSCLE; TOPOGRAPHY; TREADMILL; VASTUS LATERALIS MUSCLE; ANALYSIS OF VARIANCE; ANIMAL; BIOPHYSICS; CAT; CELL TRANSPLANTATION; CONVALESCENCE; DISEASE MODEL; DRUG EFFECT; ELECTROMYOGRAPHY; ELECTROSTIMULATION; EXERCISE TEST; INNERVATION; KINESIOTHERAPY; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; SPINAL CORD INJURY; TRANSPLANTATION;

ANALYSIS OF VARIANCE; ANIMALS; BIOPHYSICS; CATS; CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EXERCISE TEST; EXERCISE THERAPY; FEMALE; FIBROBLASTS; LOCOMOTION; MUSCLE, SKELETAL; NERVE GROWTH FACTORS; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; TRANSPLANTS;

EID: 64749104379     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00034.2008     Document Type: Article

References (45)

1. Aoyagi Y, Mushahwar VK, Stein RB, Prochazka A. Movements elicited by electrical stimulation of muscles, nerves, intermediate spinal cord, and spinal roots in anesthetized and decerebrate cats. IEEE Trans Neural Syst Rehabil Eng 12: 1-11, 2004a. (Pubitemid 38332776)
2. Aoyagi Y, Stein RB, Mushahwar VK, Prochazka A. The role of neuromuscular properties in determining the end-point of a movement. IEEE Trans Neural Syst Rehabil Eng 12: 12-23, 2004b. (Pubitemid 38332777)
3. Baldissera F, Lundberg A, Udo M. Activity evoked from the mesencephalic tegmentum in descending pathways other than the rubrospinal tract. Exp Brain Res 15: 133-150, 1972.
4. Barbeau H, Chau C, Rossignol S. Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res Bull 30: 387-393, 1993. (Pubitemid 23072748)
5. Barbeau H, Rossignol S. Recovery of locomotion after chronic spinalization in the adult cat. Brain Res 412: 84-95, 1987. (Pubitemid 17096686)
6. Barbeau H, Rossignol S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res 546: 250-260, 1991.
7. Barthélemy D, Leblond H, Provencher J, Rossignol S. Non-locomotor and locomotor hindlimb responses evoked by electrical microstimulation of the lumbar cord in spinalized cats. J Neurophysiol 96: 3273-3292, 2006.
8. Batschelet E. Circular Statistics in Biology. New York: Academic, 1981.
9. Belanger M, Drew T, Provencher J, Rossignol S. A comparison of treadmill locomotion in adult cats before and after spinal transection. J Neurophysiol 76: 471-491, 1996. (Pubitemid 26251182)
10. Bizzi E, D'Avella A, Saltiel P, Tresch M. Modular organization of spinal motor systems. Neuroscientist 8: 437-442, 2002.
11. Boyce VS, Burns AS, Lemay MA. Chronic spinal cord injury alters the proportion and distribution of spinal fields in the cat lumbar cord. In: Neural Interfaces Workshop. NIH, Bethesda, MD: 2004.
12. Boyce VS, Lemay MA. Proportions of endpoint force pattern obtained via intraspinal microstimulation chronically spinalized cats are dependent sensorimotor training. 2nd International IEEE EMBS Conference on Neural Engineering, Pentagon City, DC, 2005. (Pubitemid 43803363)
13. Boyce VS, Tumolo M, Fischer I, Murray M, Lemay MA. Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats. J Neurophysiol 98: 1988-1996, 2007. (Pubitemid 47584388)
14. Christensen R. Log-Linear Models and Logistic Regression. New York: Springer-Verlag, 1997.
15. Giszter SF, Moxon KA, Rybak I, Chapin JK. A neurobiological perspective on humanoid robot design. IEEE Intell Syst 15: 64-69, 2000.
16. Giszter SF, Mussa-Ivaldi FA, Bizzi E. Convergent force fields organized in the frog's spinal cord. J Neurosci 13: 467-491, 1993. (Pubitemid 23045133)
17. Gordon AD. Classification. Boca Raton, FL: Chapman & Hall, 1999.
18. Gustafsson B, Jankowska E. Direct and indirect activation of nerve cells by electrical pulses applied extracellularly. J Physiol 258: 33-61, 1976.
19. Hart CB, Giszter SF. Modular premotor drives and unit bursts as primitives for frog motor behaviors. J Neurosci 24: 5269-5282, 2004. (Pubitemid 38725410)
20. Himes BT, Liu Y, Solowska JM, Snyder EY, Fischer I, Tessler A. Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats. J Neurosci Res 65: 549-564, 2001. (Pubitemid 32847148)
21. Howland DR, Bregman BS, Tessler A, Goldberger ME. Transplants enhance locomotion in neonatal kittens whose spinal cords are transected: a behavioral and anatomical study. Exp Neurol 135: 123-145, 1995.
22. Jankowska E, Padel Y, Tanaka R. Projections of pyramidal tract cells to alpha-motoneurons innervating hind-limb muscles in the monkey. J Physiol 249: 637-667, 1975.
23. Kargo WJ, Giszter SF. Rapid correction of aimed movements by summation of force-field primitives. J Neurosci 20: 409-426, 2000.
24. Langlet C, Leblond H, Rossignol S. Mid-lumbar segments are needed for the expression of locomotion in chronic spinal cats. J Neurophysiol 93: 2474-2488, 2005. (Pubitemid 40570832)
25. Lemay M, Bhowmik-Stoker M, McConnell G, Grill W. Role of biomechanics and muscle activation strategy in the production of endpoint force patterns in the cat hindlimb. J Biomech 40: 3679-3687, 2007. (Pubitemid 350122513)
26. Lemay MA, Boyce VS. Effects of chronic spinalization, sensorimotor training and neuroregenerative transplants on hindlimb force patterns evoked via intraspinal microstimulation in the cat. Soc Neurosci Abstr 707.14, 2003.
27. Lemay MA, Grill WM. Modularity of motor output evoked by intraspinal microstimulation in cats. J Neurophysiol 91: 502-514, 2004.
28. Levinsson A, Holmberg H, Broman J, Zhang M, Schouenborg J. Spinal sensorimotor transformation: relation between cutaneous somatotopy and a reflex network. J Neurosci 22: 8170-8182, 2002. (Pubitemid 35379123)
29. Liu Y, Himes BT, Moul J, Huang W, Chow SY, Tessler A, Fischer I. Application of recombinant adenovirus for in vivo gene delivery to spinal cord. Brain Res 768: 19-29, 1997. (Pubitemid 27433472)
30. Liu Y, Himes BT, Solowska J, Moul J, Chow SY, Park KI, Tessler A, Murray M, Snyder EY, Fischer I. Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus. Exp Neurol 158: 9-26, 1999a. (Pubitemid 29344314)
31. Liu Y, Himes BT, Tryon B, Moul J, Chow SY, Jin H, Murray M, Tessler A, Fischer I. Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses. Neuroreport 9: 1075-1079, 1998. (Pubitemid 28266625)
32. Liu Y, Kim D, Himes BT, Chow SY, Schallert T, Murray M, Tessler A, Fischer I. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci 19: 4370-4387, 1999b. (Pubitemid 29241090)
33. Loeb EP, Giszter SF, Borghesani P, Bizzi E. Effects of dorsal root cut on the forces evoked by spinal microstimulation in the spinalized frog. Somatosens Mot Res 10: 81-95, 1993. (Pubitemid 23136479)
34. Lovely RG, Gregor RJ, Roy RR, Edgerton VR. Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat. Exp Neurol 92: 421-435, 1986.
35. McIntyre CC, Grill WM. Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. J Neurophysiol 88: 1592-1604, 2002. (Pubitemid 35191165)
36. Mushahwar VK, Aoyagi Y, Stein RB, Prochazka A. Movements generated by intraspinal microstimulation in the intermediate gray matter of the anesthetized, decerebrate, and spinal cat. Can J Physiol Pharmacol 82: 702-714, 2004. (Pubitemid 40065115)
37. Mushahwar VK, Gillard DM, Gauthier MJ, Prochazka A. Intraspinal micro stimulation generates locomotor-like and feedback-controlled movements. IEEE Trans Neural Syst Rehabil Eng 10: 68-81, 2002.
38. Mushahwar VK, Horch KW. Selective activation of muscle groups in the feline hindlimb through electrical microstimulation of the ventral lumbosacral spinal cord. IEEE Trans Rehabil Eng 8: 11-21, 2000. (Pubitemid 30230134)
39. Rossignol S, Giroux N, Chau C, Marcoux J, Brustein E, Reader TA. Pharmacological aids to locomoter training after spinal injury in the cat. J Physiol 533: 65-74, 2001. (Pubitemid 32499358)
40. Saigal R, Renzi C, Mushahwar VK. Intraspinal microstimulation generates functional movements after spinal-cord injury. IEEE Trans Neural Syst Rehabil Eng 12: 430-440, 2004. (Pubitemid 39620268)
41. Sherrington CS. Flexion-reflex of the limb, crossed extension-reflex, and reflex stepping and standing. J Physiol 40: 28-121, 1910.
42. Tai C, Booth AM, Robinson CJ, de Groat WC, Roppolo JR. Multi-joint movement of the cat hindlimb evoked by microstimulation of the lumbosacral spinal cord. Exp Neurol 183: 620-627, 2003. (Pubitemid 37205104)
43. Ting LH, Macpherson JM. A limited set of muscle synergies for force control during a postural task. J Neurophysiol 93: 609-613, 2005.
44. Torres-Oviedo G, Macpherson JM, Ting LH. Muscle synergy organization is robust across a variety of postural perturbations. J Neurophysiol 96: 1530-1546, 2006. (Pubitemid 44371541)
45. Tresch MC, Bizzi E. Responses to spinal microstimulation in the chronically spinalized rat and their relationship to spinal systems activated by low threshold cutaneous stimulation. Exp Brain Res 129: 401-416, 1999. (Pubitemid 29537612)