메뉴 건너뛰기




Volumn 15, Issue 1 SUPPL., 2009, Pages 46-52

Multiple Myeloma: Biology, Standard Therapy, and Transplant Therapy

Author keywords

Chemotherapy; genetics; multiple myeloma; Stem Cell Transplantation

Indexed keywords

4 AMINO 5 (3 BENZYLOXYPHENYL) 7 [3 (1 PYRROLIDINYLMETHYL)CYCLOBUTYL] 7H PYRROLO[2,3 D]PYRIMIDINE; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ANTINEOPLASTIC AGENT; AVN 944; BEZ 235; BORTEZOMIB; CP 51871; DEFOROLIMUS; DEHYDRODIDEMNIN B; DEXAMETHASONE; ENZASTAURIN; EVEROLIMUS; LENALIDOMIDE; MELPHALAN; PANOBINOSTAT; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PR 171; PREDNISONE; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; SCIO 469; SGN 40; TANESPIMYCIN; TANESPIMYCIN HYDROQUINONE; TEMSIROLIMUS; THALIDOMIDE; TIPIFARNIB; TKI 258; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

EID: 64749098712     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2008.10.006     Document Type: Article
Times cited : (11)

References (42)
  • 2
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    • Keats J.J., Fonseca R., Chesi M., et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 12 (2007) 131-144
    • (2007) Cancer Cell , vol.12 , pp. 131-144
    • Keats, J.J.1    Fonseca, R.2    Chesi, M.3
  • 5
    • 25144454122 scopus 로고    scopus 로고
    • Genomics in multiple myeloma: biology and clinical implications
    • Chng W.J., and Fonseca R. Genomics in multiple myeloma: biology and clinical implications. Pharmacogenomics 6 (2005) 563-573
    • (2005) Pharmacogenomics , vol.6 , pp. 563-573
    • Chng, W.J.1    Fonseca, R.2
  • 6
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: clinical applications
    • Hideshima T., Bergsagel P.L., Kuehl W.M., et al. Advances in biology of multiple myeloma: clinical applications. Blood 104 (2004) 607-618
    • (2004) Blood , vol.104 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3
  • 7
    • 1442285889 scopus 로고    scopus 로고
    • Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
    • Hurt E.M., Wiestner A., Rosenwald A., et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 5 (2004) 191-199
    • (2004) Cancer Cell , vol.5 , pp. 191-199
    • Hurt, E.M.1    Wiestner, A.2    Rosenwald, A.3
  • 8
    • 22044440425 scopus 로고    scopus 로고
    • Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
    • Bergsagel P.L., Kuehl W.M., Zhan F., et al. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 106 (2005) 296-303
    • (2005) Blood , vol.106 , pp. 296-303
    • Bergsagel, P.L.1    Kuehl, W.M.2    Zhan, F.3
  • 9
    • 0036829305 scopus 로고    scopus 로고
    • Role of the bone marrow microenvironment in multiple myeloma
    • Roodman G.D. Role of the bone marrow microenvironment in multiple myeloma. J Bone Miner Res 17 (2002) 1921-1925
    • (2002) J Bone Miner Res , vol.17 , pp. 1921-1925
    • Roodman, G.D.1
  • 12
    • 33847369790 scopus 로고    scopus 로고
    • Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART): consensus statement
    • Dispenzieri A., Rajkumar S.V., Gertz M.A., et al. Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART): consensus statement. Mayo Clin Proc 82 (2007) 323-341
    • (2007) Mayo Clin Proc , vol.82 , pp. 323-341
    • Dispenzieri, A.1    Rajkumar, S.V.2    Gertz, M.A.3
  • 13
    • 44349134345 scopus 로고    scopus 로고
    • Bortezomib-thalidomide-dexamethasone vs. thalidomide-dexamethasone in preparation for autologous stem-cell transplantation in newly diagnosed multiple myeloma (MM)
    • abstract 73
    • Cavo M., Patriarca F., Tacchetti P., et al. Bortezomib-thalidomide-dexamethasone vs. thalidomide-dexamethasone in preparation for autologous stem-cell transplantation in newly diagnosed multiple myeloma (MM). Blood 110 (2007) abstract 73
    • (2007) Blood , vol.110
    • Cavo, M.1    Patriarca, F.2    Tacchetti, P.3
  • 14
    • 54949084979 scopus 로고    scopus 로고
    • Randomized trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed myeloma (E4A03), a trial coordinated by the Eastern Cooperative Oncology Group: analysis of response, survival, and outcome wi
    • abstract 8504
    • Rajkumar S.V., Jacobus S., Callander N., et al. Randomized trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed myeloma (E4A03), a trial coordinated by the Eastern Cooperative Oncology Group: analysis of response, survival, and outcome wi. J Clin Oncol 26 (2008) abstract 8504
    • (2008) J Clin Oncol , vol.26
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.3
  • 15
    • 54049135250 scopus 로고    scopus 로고
    • Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial
    • Epub 2008 May 27
    • Palumbo A., Bringhen S., Liberati A.M., Caravita T., Falcone A., Callea V., et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial. Blood 112 8 (2008 Oct 15) 3107-3114 Epub 2008 May 27
    • (2008) Blood , vol.112 , Issue.8 , pp. 3107-3114
    • Palumbo, A.1    Bringhen, S.2    Liberati, A.M.3    Caravita, T.4    Falcone, A.5    Callea, V.6
  • 16
    • 44649108963 scopus 로고    scopus 로고
    • Prolonged overall survival with lenalidomide plus dexamethasone compared with dexamethasone alone in patients with relapsed or refractory multiple myeloma
    • abstract 412
    • Weber D., Knight R., Chen C., et al. Prolonged overall survival with lenalidomide plus dexamethasone compared with dexamethasone alone in patients with relapsed or refractory multiple myeloma. Blood 110 (2007) abstract 412
    • (2007) Blood , vol.110
    • Weber, D.1    Knight, R.2    Chen, C.3
  • 17
    • 44649143334 scopus 로고    scopus 로고
    • Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma
    • Paripati H., Stewart A.K., Cabou S., et al. Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma. Leukemia 22 (2008) 1282-1284
    • (2008) Leukemia , vol.22 , pp. 1282-1284
    • Paripati, H.1    Stewart, A.K.2    Cabou, S.3
  • 18
    • 41349101245 scopus 로고    scopus 로고
    • MMY-3002: a phase 3 study comparing bortezomib-melphalan-prednisone (VMP) with melphalan-prednisone (MP) in newly diagnosed multiple myeloma
    • abstract 76
    • San Miguel J.F., Schlag R., Khuageva N., et al. MMY-3002: a phase 3 study comparing bortezomib-melphalan-prednisone (VMP) with melphalan-prednisone (MP) in newly diagnosed multiple myeloma. Blood 110 (2007) abstract 76
    • (2007) Blood , vol.110
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.3
  • 19
    • 36749094612 scopus 로고    scopus 로고
    • Comparison of melphalan-prednisone-thalidomide (MP-T) to melphalan-prednisone (MP) in patients 75 years of age or older with untreated multiple myeloma (MM). Preliminary results of the randomized, double-blind, placebo-controlled IFM 01-01 trial
    • abstract 8001
    • Hulin C., Virion J., Leleu X., et al. Comparison of melphalan-prednisone-thalidomide (MP-T) to melphalan-prednisone (MP) in patients 75 years of age or older with untreated multiple myeloma (MM). Preliminary results of the randomized, double-blind, placebo-controlled IFM 01-01 trial. J Clin Oncol 25 (2007) abstract 8001
    • (2007) J Clin Oncol , vol.25
    • Hulin, C.1    Virion, J.2    Leleu, X.3
  • 20
    • 35348923502 scopus 로고    scopus 로고
    • Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA, Italian Multiple Myeloma Network
    • Palumbo A., Falco P., Corradini P., et al. Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA, Italian Multiple Myeloma Network. J Clin Oncol 25 (2007) 4459-4465
    • (2007) J Clin Oncol , vol.25 , pp. 4459-4465
    • Palumbo, A.1    Falco, P.2    Corradini, P.3
  • 21
    • 51349103508 scopus 로고    scopus 로고
    • Lenalidomide overcomes poor prognosis conferred by del13q and t(4;14) but not del17p13 in multiple myeloma: results of the Canadian MM016 trial
    • abstract 3597
    • Bahlis N.J., Song K., Trieu Y., et al. Lenalidomide overcomes poor prognosis conferred by del13q and t(4;14) but not del17p13 in multiple myeloma: results of the Canadian MM016 trial. Blood 110 (2007) abstract 3597
    • (2007) Blood , vol.110
    • Bahlis, N.J.1    Song, K.2    Trieu, Y.3
  • 22
    • 36148973115 scopus 로고    scopus 로고
    • Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis
    • Chen N., Lau H., Kong L., et al. Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis. J Clin Pharmacol 47 (2007) 1466-1475
    • (2007) J Clin Pharmacol , vol.47 , pp. 1466-1475
    • Chen, N.1    Lau, H.2    Kong, L.3
  • 23
    • 46749152199 scopus 로고    scopus 로고
    • Treatment of patients with multiple myeloma complicated by renal failure with bortezomib-based regimens
    • Roussou M., Kastritis E., Migkou M., et al. Treatment of patients with multiple myeloma complicated by renal failure with bortezomib-based regimens. Leuk Lymphoma 49 (2008) 890-895
    • (2008) Leuk Lymphoma , vol.49 , pp. 890-895
    • Roussou, M.1    Kastritis, E.2    Migkou, M.3
  • 24
    • 35748965609 scopus 로고    scopus 로고
    • Role of stem cell transplantation
    • Harousseau J.L. Role of stem cell transplantation. Hematol Oncol Clin North Am 21 (2007) 1157-1174
    • (2007) Hematol Oncol Clin North Am , vol.21 , pp. 1157-1174
    • Harousseau, J.L.1
  • 25
    • 38549144944 scopus 로고    scopus 로고
    • Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma
    • Lokhorst H.M., Schmidt-Wolf I., Sonneveld P., et al. Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma. Haematologica 93 (2008) 124-127
    • (2008) Haematologica , vol.93 , pp. 124-127
    • Lokhorst, H.M.1    Schmidt-Wolf, I.2    Sonneveld, P.3
  • 26
    • 58149376363 scopus 로고    scopus 로고
    • Thalidomide combinations improve response rates: results from the MRC IX study
    • [abstract]
    • Morgan G.J., Davies F.E., and Owen R.G. Thalidomide combinations improve response rates: results from the MRC IX study. [abstract]. Blood 110 (2007) 1051
    • (2007) Blood , vol.110 , pp. 1051
    • Morgan, G.J.1    Davies, F.E.2    Owen, R.G.3
  • 27
    • 62649159169 scopus 로고    scopus 로고
    • Bortezomib/dexamethasone versus VAD as induction prior to autologous stem-cell transplantation in previously untreated multiple myeloma: updated results from IFM 2005/01 trial
    • [abstract]
    • Harousseau J.-L., Mathiot C., and Attal M. Bortezomib/dexamethasone versus VAD as induction prior to autologous stem-cell transplantation in previously untreated multiple myeloma: updated results from IFM 2005/01 trial. [abstract]. J Clin Oncol 26 (2008) 455
    • (2008) J Clin Oncol , vol.26 , pp. 455
    • Harousseau, J.-L.1    Mathiot, C.2    Attal, M.3
  • 28
    • 44349134345 scopus 로고    scopus 로고
    • Bortezomib-thalidomide-dexamethasone vs. thalidomide-dexamethasone in preparation for autologous stem-cell transplantation in newly diagnosed multiple myeloma
    • [abstract]
    • Cavo M., Patriarca F., and Tacchetti P. Bortezomib-thalidomide-dexamethasone vs. thalidomide-dexamethasone in preparation for autologous stem-cell transplantation in newly diagnosed multiple myeloma. [abstract]. Blood 110 (2007) 30
    • (2007) Blood , vol.110 , pp. 30
    • Cavo, M.1    Patriarca, F.2    Tacchetti, P.3
  • 29
    • 54049148621 scopus 로고    scopus 로고
    • Thalidomide arm of total therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities
    • Epub 2008 May 20
    • Barlogie B., Pineda-Roman M., and Van Rhee F. Thalidomide arm of total therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities. Blood 112 8 (2008 Oct 15) 3115-3121 Epub 2008 May 20
    • (2008) Blood , vol.112 , Issue.8 , pp. 3115-3121
    • Barlogie, B.1    Pineda-Roman, M.2    Van Rhee, F.3
  • 30
    • 39749085426 scopus 로고    scopus 로고
    • Sustained complete remissions in multiple myeloma linked to bortezomib in Total Therapy 3: comparison with Total Therapy 2
    • Pineda-Roman M., Zangari M., Haessler J., et al. Sustained complete remissions in multiple myeloma linked to bortezomib in Total Therapy 3: comparison with Total Therapy 2. Br J Haematol 140 (2008) 625-634
    • (2008) Br J Haematol , vol.140 , pp. 625-634
    • Pineda-Roman, M.1    Zangari, M.2    Haessler, J.3
  • 31
    • 33644843725 scopus 로고    scopus 로고
    • Italian Multiple Myeloma Network, GIMEMA. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial
    • Palumbo A., Bringhen S., Caravita T., Merla E., Capparella V., Callea V., et al. Italian Multiple Myeloma Network, GIMEMA. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial. Lancet 367 9513 (2006 Mar 11) 825-831
    • (2006) Lancet , vol.367 , Issue.9513 , pp. 825-831
    • Palumbo, A.1    Bringhen, S.2    Caravita, T.3    Merla, E.4    Capparella, V.5    Callea, V.6
  • 32
    • 50449086728 scopus 로고    scopus 로고
    • VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel J.F., Schlag R., Khuageva N.K., Dimopoulos M.A., Shpilberg O., Kropff M., et al. VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 359 9 (2008 Aug 28) 906-917
    • (2008) N Engl J Med , vol.359 , Issue.9 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3    Dimopoulos, M.A.4    Shpilberg, O.5    Kropff, M.6
  • 33
    • 35348923502 scopus 로고    scopus 로고
    • GIMEMA--Italian Multiple Myeloma Network. Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA--Italian Multiple Myeloma Network
    • Epub 2007 Sep 4
    • Palumbo A., Falco P., Corradini P., Falcone A., Di Raimondo F., Giuliani N., et al. GIMEMA--Italian Multiple Myeloma Network. Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA--Italian Multiple Myeloma Network. J Clin Oncol 25 28 (2007 Oct 1) 4459-4465 Epub 2007 Sep 4
    • (2007) J Clin Oncol , vol.25 , Issue.28 , pp. 4459-4465
    • Palumbo, A.1    Falco, P.2    Corradini, P.3    Falcone, A.4    Di Raimondo, F.5    Giuliani, N.6
  • 34
    • 38949216066 scopus 로고    scopus 로고
    • BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma
    • Niesvizky R., Jayabalan D.S., Christos P.J., et al. BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma. Blood 111 (2008) 1101-1109
    • (2008) Blood , vol.111 , pp. 1101-1109
    • Niesvizky, R.1    Jayabalan, D.S.2    Christos, P.J.3
  • 35
    • 54749087249 scopus 로고    scopus 로고
    • Safety and efficacy of lenalidomide (Len), bortezomib (Bz), and dexamethasone (Dex) in patients (pts) with newly diagnosed multiple myeloma (MM): A phase I/II study
    • (May 20 suppl; abstr 8520)
    • Richardson P.G., Lonial S., Jakubowiak A., Jagannath S., Raje N., Avigan D., et al. Safety and efficacy of lenalidomide (Len), bortezomib (Bz), and dexamethasone (Dex) in patients (pts) with newly diagnosed multiple myeloma (MM): A phase I/II study. J Clin Oncol 26 (2008) (May 20 suppl; abstr 8520)
    • (2008) J Clin Oncol , vol.26
    • Richardson, P.G.1    Lonial, S.2    Jakubowiak, A.3    Jagannath, S.4    Raje, N.5    Avigan, D.6
  • 36
    • 41349095820 scopus 로고    scopus 로고
    • A randomized trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma: a trial coordinated by the Eastern Cooperative Oncology Group
    • [abstract]
    • Rajkumar S.V., Jacobus S., and Callander N. A randomized trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma: a trial coordinated by the Eastern Cooperative Oncology Group. [abstract]. Blood 110 (2007) 31
    • (2007) Blood , vol.110 , pp. 31
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.3
  • 38
    • 33947197286 scopus 로고    scopus 로고
    • A comparison of allografting with autografting for newly diagnosed myeloma
    • Bruno B., Rotta M., Patriarca F., et al. A comparison of allografting with autografting for newly diagnosed myeloma. N Engl J Med 356 (2007) 1110-1120
    • (2007) N Engl J Med , vol.356 , pp. 1110-1120
    • Bruno, B.1    Rotta, M.2    Patriarca, F.3
  • 39
    • 33646401089 scopus 로고    scopus 로고
    • Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
    • Garban F., Attal M., Michallet M., et al. Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma. Blood 107 (2006) 3474-3480
    • (2006) Blood , vol.107 , pp. 3474-3480
    • Garban, F.1    Attal, M.2    Michallet, M.3
  • 40
    • 55749099328 scopus 로고    scopus 로고
    • A prospective PETHEMA study of tandem autologous transplant versus autograft followed by reduced-intensity conditioning allogeneic transplant in newly diagnosed multiple myeloma
    • Epub 2008 Jul 8
    • Rosinol L., Perez-Simon J.A., and Sureda A. A prospective PETHEMA study of tandem autologous transplant versus autograft followed by reduced-intensity conditioning allogeneic transplant in newly diagnosed multiple myeloma. Blood 112 8 (2008 Nov 1) 3591-3593 Epub 2008 Jul 8
    • (2008) Blood , vol.112 , Issue.8 , pp. 3591-3593
    • Rosinol, L.1    Perez-Simon, J.A.2    Sureda, A.3
  • 41
    • 55749090051 scopus 로고    scopus 로고
    • Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma
    • IFM Group
    • Moreau P., Garban F., Attal M., Michallet M., Marit G., Hulin C., et al., IFM Group. Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma. Blood 112 9 (2008 Nov 1) 3914-3915
    • (2008) Blood , vol.112 , Issue.9 , pp. 3914-3915
    • Moreau, P.1    Garban, F.2    Attal, M.3    Michallet, M.4    Marit, G.5    Hulin, C.6
  • 42
    • 55749099328 scopus 로고    scopus 로고
    • Programa para el Estudio y la Terapéutica de las Hemopatías Malignas y Grupo Español de Mieloma (PETHEMA/GEM). A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma
    • Epub 2008 Jul 8
    • Rosiñol L., Pérez-Simón J.A., Sureda A., de la Rubia J., de Arriba F., Lahuerta J.J., et al. Programa para el Estudio y la Terapéutica de las Hemopatías Malignas y Grupo Español de Mieloma (PETHEMA/GEM). A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma. Blood 112 9 (2008 Nov 1) 3591-3593 Epub 2008 Jul 8
    • (2008) Blood , vol.112 , Issue.9 , pp. 3591-3593
    • Rosiñol, L.1    Pérez-Simón, J.A.2    Sureda, A.3    de la Rubia, J.4    de Arriba, F.5    Lahuerta, J.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.