Dimethyl amiloride, a Na+-H+ exchange inhibitor, and its cardioprotective effects in hemorrhagic shock in in vivo resuscitated rats

Journal of Physiological Sciences

Volumn 59, Issue 3, 2009, Pages 175-180

  Soliman, Mona ^a  

^a KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

Author keywords

Calcium; Contractility; Dimethyl amiloride; Hemorrhage; Isolated heart; Lactate; Langendorff; pH; Rat; Sodium

Indexed keywords

AMILORIDE DERIVATIVE; DIMETHYL AMILORIDE; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG; 5-DIMETHYLAMILORIDE; AMILORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIASTOLIC BLOOD PRESSURE; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; HEMORRHAGIC SHOCK; NONHUMAN; RAT; RESUSCITATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DOSE RESPONSE; DRUG EFFECTS; HEART CONTRACTION; HEART FAILURE; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

AMILORIDE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART FAILURE; MALE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; RESUSCITATION; SHOCK, HEMORRHAGIC; SODIUM-HYDROGEN ANTIPORTER; TIME FACTORS;

EID: 64749096510     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12576-009-0024-z     Document Type: Article

References (25)

1. JW Horton 1989 Hemorrhagic shock depresses myocardial contractile function in the guinea pig Circ Shock 28 1 23 35
2. M Lazdunski C Frelin P Vigne 1985 The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH J Mol Cell Cardiol 17 1029 1042
3. H Cingolani Y Koretsune E Marban 1990 Recovery of contractility and pH during respiratory acidosis in ferret hearts: role of Na-H exchange Am J Physiol 259 H843 H848
4. AR Mattiazzi H Cingolani 1977 Biphasic effect of hypercapnia on myocardial contrctility Arch Int Phys Biochem 85 11 25
5. J Horton G McDonald 1990 Heart and brain nucleotide pools during hemorrhage and resuscitation Am J Physiol 259 6 H1788
6. S Turvey DJ Allen 1994 Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart Cardiovasc Res 28 987 993
7. DG Renlund 1984 Perfusate sodium during ischemia modifies post-ischemic functional and metabolic recovery in the rabbit heart J Mol Cell Cardiol 16 795 801
8. JA Lee DJ Allen 1992 Changes in intracellular free calcium concentration during long exposures to simulated ischemia in isolated mammalian ventricular muscle Circ Res 71 58 69
9. M Tani JR Neely 1989 Role of intracellular Na in Ca overload and depressed recovery of ventricular function of reperfused ischemic rat hearts Circ Res 65 1045 1056
10. E Murphy 1991 Amiloride delays the ischemia-induced rise in cytosolic free calcium Circ Res 68 1250 1258
11. M Karmazyn 1988 Amiloride enhance post-ischemic ventricular recovery: possible role of Na/H exchange Am J Physiol 255 H608 H615
12. M Karmazyn M Ray J Haist 1993 Comparative effects of Na/H exchange inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox J Cardiovasc Pharmacol 21: 172 178
13. R Raymond 2002 Myocardial dysfunction during acute hemorrhagic hypotension in the rat J Saudi Heart Assoc 14 4 204 212
14. M Soliman R Raymond 2005 Effects of cardiac Na-H exchange blockade on myocardial contractile dysfunction during hemorrhagic shock J Saudi Heart Assoc 17 1 33 42
15. TR Kleyman JE Cragoe 1988 Amiloride and its analogues as tools in the study of ion transport J Membr Biol 105 1 21
16. S Dennis 1990 Effects of proton buffering and of amiloride derivatives on reperfusion arrhythmias in isolated rat heart Circ Res 66 1156 1159
17. W Scholz 1995 Protective effects of HOE 642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischemia and reperfusion Cardiovasc Res 29 260 268
18. O Frohlich M Karmazyn 1997 The Na-H exchanger revisited: an update on Na-H exchange regulation and the role of the exchanger in hypertention and cardiac function in health and disease Cardiovasc Res 36 138 148
19. M Karmazyn 1996 The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications Can J Cardiol 12:1074-1082 12 1074 1082
20. GN Pierce MP Czubryt 1995 The contribution of ionic imbalance to ischemia-reperfusion induced injury J Mol Cell Cardiol 27 53 63
21. P Theroux 2000 Myocardial call protection Circulation 101:2874-2876 101 2874 2876
22. HP Meng BB Lonsberry GN Pierce 1991 Influence of perfusate pH on the postischemic recovery of cardiac contractile function: involvement of sodium-hydrogen exchange J Pharmacol Exp Ther 258 3 772 777
23. C Hurtado N Pierce 2000 Inhibition of Na/H exchange at the begining of reperfusion is cardioprotective in isolated, beating adult cardiomyocytes J Mol Cell Cardiol 32 1897 1907
24. + exchanger inhibition with BIIB513 following hypovolemic circulatory shock Shock 23 3 269 274
25. + exchange inhibition delays the onset of hypovolemic circulatory shock in pigs Shock 29 4 519 525