메뉴 건너뛰기




Volumn 53, Issue 5, 2009, Pages 779-789

Effect of the MTHFR C677T and A1298C Polymorphisms on Survival in Patients With Advanced CKD and ESRD: A Prospective Study

Author keywords

advanced chronic kidney disease; end stage renal disease; Methylenetetrahydrofolate reductase gene polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; MULTIVITAMIN; PYRIDOXINE;

EID: 64749085617     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.12.023     Document Type: Article
Times cited : (20)

References (41)
  • 1
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., et al. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10 (1995) 111-113
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 2
    • 0001467691 scopus 로고    scopus 로고
    • Folate metabolism
    • Carmel R., and Jacobsen D.W. (Eds), University Press, Cambridge, UK
    • Cook R.J. Folate metabolism. In: Carmel R., and Jacobsen D.W. (Eds). Homocysteine in Health and Disease (2001), University Press, Cambridge, UK 113-134
    • (2001) Homocysteine in Health and Disease , pp. 113-134
    • Cook, R.J.1
  • 3
    • 0034743914 scopus 로고    scopus 로고
    • The 1298A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): In vitro expression and association with homocysteine
    • Weisberg I.S., Jacques P.F., Selhub J., et al. The 1298A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): In vitro expression and association with homocysteine. Atherosclerosis 156 (2001) 409-415
    • (2001) Atherosclerosis , vol.156 , pp. 409-415
    • Weisberg, I.S.1    Jacques, P.F.2    Selhub, J.3
  • 4
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • Wald D.S., Law M., and Morris J.K. Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. BMJ 325 (2002) 1202-1206
    • (2002) BMJ , vol.325 , pp. 1202-1206
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 5
    • 0037163849 scopus 로고    scopus 로고
    • MTHFR 677C→T polymorphism and risk of coronary heart disease: A meta-analysis
    • Klerk M., Verhoef P., Clarke R., et al. MTHFR 677C→T polymorphism and risk of coronary heart disease: A meta-analysis. JAMA 288 (2002) 2023-2031
    • (2002) JAMA , vol.288 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3
  • 6
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?
    • Lewis S.J., Ebrahim S., and Davey Smith G. Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?. BMJ 331 (2005) 1053-1058
    • (2005) BMJ , vol.331 , pp. 1053-1058
    • Lewis, S.J.1    Ebrahim, S.2    Davey Smith, G.3
  • 7
    • 35648952788 scopus 로고    scopus 로고
    • Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization
    • Pereira A.C., Miyakawa A.A., Lopes N.H., et al. Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization. Thromb Res 121 (2007) 25-32
    • (2007) Thromb Res , vol.121 , pp. 25-32
    • Pereira, A.C.1    Miyakawa, A.A.2    Lopes, N.H.3
  • 8
    • 34447517369 scopus 로고    scopus 로고
    • Influence of 677 C→T polymorphism of methylenetetrahydrofolate reductase on medium-term prognosis after acute coronary syndromes
    • Garcia-Pinilla J.M., Espinosa-Caliani S., Jimenez-Navarro M., et al. Influence of 677 C→T polymorphism of methylenetetrahydrofolate reductase on medium-term prognosis after acute coronary syndromes. Tex Heart Inst J 34 (2007) 142-147
    • (2007) Tex Heart Inst J , vol.34 , pp. 142-147
    • Garcia-Pinilla, J.M.1    Espinosa-Caliani, S.2    Jimenez-Navarro, M.3
  • 9
    • 34248339280 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C→T and methionine synthase 2756A→G mutations: No impact on survival, cognitive functioning, or cognitive decline in nonagenarians
    • Bathum L., von Bornemann Hjelmborg J., Christiansen L., et al. Methylenetetrahydrofolate reductase 677C→T and methionine synthase 2756A→G mutations: No impact on survival, cognitive functioning, or cognitive decline in nonagenarians. J Gerontol A Biol Sci Med Sci 62 (2007) 196-201
    • (2007) J Gerontol A Biol Sci Med Sci , vol.62 , pp. 196-201
    • Bathum, L.1    von Bornemann Hjelmborg, J.2    Christiansen, L.3
  • 10
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I., Tran P., Christensen B., et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64 (1998) 169-172
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3
  • 11
    • 2342485635 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease
    • Kolling K., Ndrepepa G., Koch W., et al. Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease. Am J Cardiol 93 (2004) 1201-1206
    • (2004) Am J Cardiol , vol.93 , pp. 1201-1206
    • Kolling, K.1    Ndrepepa, G.2    Koch, W.3
  • 12
    • 33750942294 scopus 로고    scopus 로고
    • Association of MTHFR gene polymorphisms with breast cancer survival
    • Martin D.N., Boersma B.J., Howe T.M., et al. Association of MTHFR gene polymorphisms with breast cancer survival. BMC Cancer 6 (2006) 257
    • (2006) BMC Cancer , vol.6 , pp. 257
    • Martin, D.N.1    Boersma, B.J.2    Howe, T.M.3
  • 13
    • 0030851289 scopus 로고    scopus 로고
    • Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients
    • Fodinger M., Mannhalter C., Wolfl G., et al. Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients. Kidney Int 52 (1997) 517-523
    • (1997) Kidney Int , vol.52 , pp. 517-523
    • Fodinger, M.1    Mannhalter, C.2    Wolfl, G.3
  • 14
    • 33646158696 scopus 로고    scopus 로고
    • Phenotypic and genotypic risk factors for cardiovascular events in an incident dialysis cohort
    • Pernod G., Bosson J.L., Golshayan D., et al. Phenotypic and genotypic risk factors for cardiovascular events in an incident dialysis cohort. Kidney Int 69 (2006) 1424-1430
    • (2006) Kidney Int , vol.69 , pp. 1424-1430
    • Pernod, G.1    Bosson, J.L.2    Golshayan, D.3
  • 15
    • 0035720334 scopus 로고    scopus 로고
    • An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease
    • Wrone E.M., Zehnder J.L., Hornberger J.M., et al. An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease. Kidney Int 60 (2001) 1106-1113
    • (2001) Kidney Int , vol.60 , pp. 1106-1113
    • Wrone, E.M.1    Zehnder, J.L.2    Hornberger, J.M.3
  • 16
    • 0031662210 scopus 로고    scopus 로고
    • MTHFR association with arteriosclerotic vascular disease?
    • Fletcher O., and Kessling A.M. MTHFR association with arteriosclerotic vascular disease?. Hum Genet 103 (1998) 11-21
    • (1998) Hum Genet , vol.103 , pp. 11-21
    • Fletcher, O.1    Kessling, A.M.2
  • 17
    • 14044261165 scopus 로고    scopus 로고
    • The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: Results of a multicentre prospective study
    • Aucella F., Margaglione M., Grandone E., et al. The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: Results of a multicentre prospective study. Nephrol Dial Transplant 20 (2005) 382-386
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 382-386
    • Aucella, F.1    Margaglione, M.2    Grandone, E.3
  • 18
    • 0034058544 scopus 로고    scopus 로고
    • The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients
    • Kimura H., Gejyo F., Suzuki S., et al. The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients. J Am Soc Nephrol 11 (2000) 885-893
    • (2000) J Am Soc Nephrol , vol.11 , pp. 885-893
    • Kimura, H.1    Gejyo, F.2    Suzuki, S.3
  • 19
    • 34548566329 scopus 로고    scopus 로고
    • Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial
    • Jamison R.L., Hartigan P., Kaufman J.S., et al. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial. JAMA 298 (2007) 1163-1170
    • (2007) JAMA , vol.298 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3
  • 20
    • 0037178556 scopus 로고    scopus 로고
    • Multiplex PCR for simultaneous detection of 677 C→T and 1298 A→C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk
    • Yi P., Pogribny I., and Jill James S. Multiplex PCR for simultaneous detection of 677 C→T and 1298 A→C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk. Cancer Lett 181 (2002) 209-213
    • (2002) Cancer Lett , vol.181 , pp. 209-213
    • Yi, P.1    Pogribny, I.2    Jill James, S.3
  • 23
    • 34447318860 scopus 로고    scopus 로고
    • Vascular access in haemodialysis patients: A modifiable risk factor for bacteraemia and death
    • Thomson P.C., Stirling C.M., Geddes C.C., et al. Vascular access in haemodialysis patients: A modifiable risk factor for bacteraemia and death. QJM 100 (2007) 415-422
    • (2007) QJM , vol.100 , pp. 415-422
    • Thomson, P.C.1    Stirling, C.M.2    Geddes, C.C.3
  • 24
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully K.S. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol 56 (1969) 111-128
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 25
    • 0000167774 scopus 로고
    • Disorders of transsulfuration
    • Crever C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds), McGraw-Hill, New York, NY
    • Mudd S.H., Levy H.L., and Skovby F. Disorders of transsulfuration. In: Crever C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The Metabolic Basis of Inherited Disease. (ed 7) (1994), McGraw-Hill, New York, NY 1279-1327
    • (1994) The Metabolic Basis of Inherited Disease. (ed 7) , pp. 1279-1327
    • Mudd, S.H.1    Levy, H.L.2    Skovby, F.3
  • 26
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey C.J., Beresford S.A., Omenn G.S., et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274 (1995) 1049-1057
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3
  • 27
    • 10544252271 scopus 로고    scopus 로고
    • Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations
    • Robinson K., Gupta A., Dennis V., et al. Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation 94 (1996) 2743-2748
    • (1996) Circulation , vol.94 , pp. 2743-2748
    • Robinson, K.1    Gupta, A.2    Dennis, V.3
  • 28
    • 0030904875 scopus 로고    scopus 로고
    • The natural history of vascular disease in homocystinuria and the effects of treatment
    • Wilcken D.E., and Wilcken B. The natural history of vascular disease in homocystinuria and the effects of treatment. J Inherit Metab Dis 20 (1997) 295-300
    • (1997) J Inherit Metab Dis , vol.20 , pp. 295-300
    • Wilcken, D.E.1    Wilcken, B.2
  • 29
    • 1842370239 scopus 로고    scopus 로고
    • Plasma homocysteine levels and mortality in patients with coronary artery disease
    • Nygard O., Nordrehaug J.E., Refsum H., et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337 (1997) 230-236
    • (1997) N Engl J Med , vol.337 , pp. 230-236
    • Nygard, O.1    Nordrehaug, J.E.2    Refsum, H.3
  • 30
    • 0031471941 scopus 로고    scopus 로고
    • Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study
    • Bostom A.G., Shemin D., Verhoef P., et al. Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study. Arterioscler Thromb Vasc Biol 17 (1997) 2554-2558
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2554-2558
    • Bostom, A.G.1    Shemin, D.2    Verhoef, P.3
  • 31
    • 0032401552 scopus 로고    scopus 로고
    • A common methylenetetrahydrofolate reductase gene mutation and longevity
    • Brattstrom L., Zhang Y., Hurtig M., et al. A common methylenetetrahydrofolate reductase gene mutation and longevity. Atherosclerosis 141 (1998) 315-319
    • (1998) Atherosclerosis , vol.141 , pp. 315-319
    • Brattstrom, L.1    Zhang, Y.2    Hurtig, M.3
  • 32
    • 0033533527 scopus 로고    scopus 로고
    • Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence
    • Eikelboom J.W., Lonn E., Genest Jr. J., et al. Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence. Ann Intern Med 131 (1999) 363-375
    • (1999) Ann Intern Med , vol.131 , pp. 363-375
    • Eikelboom, J.W.1    Lonn, E.2    Genest Jr., J.3
  • 33
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    • Toole J.F., Malinow M.R., Chambless L.E., et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291 (2004) 565-575
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3
  • 34
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Bonaa K.H., Njolstad I., Ueland P.M., et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354 (2006) 1578-1588
    • (2006) N Engl J Med , vol.354 , pp. 1578-1588
    • Bonaa, K.H.1    Njolstad, I.2    Ueland, P.M.3
  • 35
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in vascular disease
    • Lonn E., Yusuf S., Arnold M.J., et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354 (2006) 1567-1577
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3
  • 36
    • 33645777279 scopus 로고    scopus 로고
    • Homocysteine trials-Clear outcomes for complex reasons
    • Loscalzo J. Homocysteine trials-Clear outcomes for complex reasons. N Engl J Med 354 (2006) 1629-1632
    • (2006) N Engl J Med , vol.354 , pp. 1629-1632
    • Loscalzo, J.1
  • 37
    • 0002051637 scopus 로고    scopus 로고
    • Polymorphisms of folate and cobalamin metabolism
    • Carmel R., and Jacobsen D. (Eds), Cambridge University, Cambridge, UK
    • Rozen R. Polymorphisms of folate and cobalamin metabolism. In: Carmel R., and Jacobsen D. (Eds). Homocysteine in Health and Disease (2001), Cambridge University, Cambridge, UK 259-269
    • (2001) Homocysteine in Health and Disease , pp. 259-269
    • Rozen, R.1
  • 38
    • 0031961002 scopus 로고    scopus 로고
    • Worldwide distribution of a common methylenetetrahydrofolate reductase mutation
    • Schneider J.A., Rees D.C., Liu Y.T., et al. Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. Am J Hum Genet 62 (1998) 1258-1260
    • (1998) Am J Hum Genet , vol.62 , pp. 1258-1260
    • Schneider, J.A.1    Rees, D.C.2    Liu, Y.T.3
  • 39
    • 0031017820 scopus 로고    scopus 로고
    • Differences in methylenetetrahydrofolate reductase genotype frequencies, between whites and blacks
    • Stevenson R.E., Schwartz C.E., Du Y.Z., et al. Differences in methylenetetrahydrofolate reductase genotype frequencies, between whites and blacks. Am J Hum Genet 60 (1997) 229-230
    • (1997) Am J Hum Genet , vol.60 , pp. 229-230
    • Stevenson, R.E.1    Schwartz, C.E.2    Du, Y.Z.3
  • 40
    • 33749252374 scopus 로고    scopus 로고
    • Revisiting survival differences by race and ethnicity among hemodialysis patients: The Dialysis Outcomes and Practice Patterns Study
    • Robinson B.M., Joffe M.M., Pisoni R.L., et al. Revisiting survival differences by race and ethnicity among hemodialysis patients: The Dialysis Outcomes and Practice Patterns Study. J Am Soc Nephrol 17 (2006) 2910-2918
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2910-2918
    • Robinson, B.M.1    Joffe, M.M.2    Pisoni, R.L.3
  • 41
    • 33845995081 scopus 로고    scopus 로고
    • Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy
    • Boger C.A., Stubanus M., Haak T., et al. Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy. Nephrol Dial Transplant 22 (2007) 154-162
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 154-162
    • Boger, C.A.1    Stubanus, M.2    Haak, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.