메뉴 건너뛰기




Volumn 20, Issue 2, 2005, Pages 382-386

The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: Results of a multicentre prospective study

Author keywords

Cardiovascular disease; Dialysis; Genetics; Mortality; MTHFR

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA;

EID: 14044261165     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh620     Document Type: Article
Times cited : (19)

References (19)
  • 1
    • 0034020446 scopus 로고    scopus 로고
    • Cardiovascular risk in uraemic patients - Is it fully explained by classical risk factors?
    • Zoccali C. Cardiovascular risk in uraemic patients - is it fully explained by classical risk factors? Nephrol Dial Transplant 2000; 15: 454-457
    • (2000) Nephrol. Dial. Transplant. , vol.15 , pp. 454-457
    • Zoccali, C.1
  • 3
    • 0029911977 scopus 로고    scopus 로고
    • Homocysteinemia and vascular disease in end-stage renal disease
    • Dennis VW, Robinson K. Homocysteinemia and vascular disease in end-stage renal disease. Kidney Int Suppl 1996; 57: S11-S17
    • (1996) Kidney Int. Suppl. , vol.57
    • Dennis, V.W.1    Robinson, K.2
  • 4
    • 0031914677 scopus 로고    scopus 로고
    • Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease
    • Moustapha A, Naso A, Nahlawi M et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998; 97: 138-141
    • (1998) Circulation , vol.97 , pp. 138-141
    • Moustapha, A.1    Naso, A.2    Nahlawi, M.3
  • 6
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-113
    • (1995) Nat. Genet. , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 7
    • 0030851289 scopus 로고    scopus 로고
    • Mutation. (677°C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients
    • Födinger M, Mannhalter C, Wolf. G et al. Mutation (677°C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients. Kidney Int 1997: 52: 517-523
    • (1997) Kidney Int. , vol.52 , pp. 517-523
    • Födinger, M.1    Mannhalter, C.2    Wolf, G.3
  • 9
    • 0036377016 scopus 로고    scopus 로고
    • The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients
    • Haviv YS, Shpichinetsky V, Goldschmidt N, Atta IA, Ben-Yehuda A, Friedman G. The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients. Nephron 2002; 92: 120-126
    • (2002) Nephron , vol.92 , pp. 120-126
    • Haviv, Y.S.1    Shpichinetsky, V.2    Goldschmidt, N.3    Atta, I.A.4    Ben-Yehuda, A.5    Friedman, G.6
  • 10
    • 0036137128 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia, and cardiovascular diseases in chronic hemodialysis patients
    • Morimoto K, Haneda T, Okamoto K, Ishida H, Kikuchi K. Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia, and cardiovascular diseases in chronic hemodialysis patients. Nephron 2002; 90: 43-50
    • (2002) Nephron , vol.90 , pp. 43-50
    • Morimoto, K.1    Haneda, T.2    Okamoto, K.3    Ishida, H.4    Kikuchi, K.5
  • 11
    • 0032773817 scopus 로고    scopus 로고
    • Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (mthfr) gene in offspring of patients with myocardial infarction
    • Margaglione M, Colaizzo D, Cappucci G et al. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (mthfr) gene in offspring of patients with myocardial infarction. Thromb Haemostasis 1999; 82: 19-23
    • (1999) Thromb. Haemostasis , vol.82 , pp. 19-23
    • Margaglione, M.1    Colaizzo, D.2    Cappucci, G.3
  • 12
    • 0033545888 scopus 로고    scopus 로고
    • Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening
    • The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
    • McQuillan BM, Beilby JP, Nidorf M, Thompson PL, Hung J. Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS). Circulation 1999; 99: 2383-2388
    • (1999) Circulation , vol.99 , pp. 2383-2388
    • McQuillan, B.M.1    Beilby, J.P.2    Nidorf, M.3    Thompson, P.L.4    Hung, J.5
  • 13
    • 0032555167 scopus 로고    scopus 로고
    • Prospective study of coronary artery disease incidence in relation to fasting homocysteine, related genetic polymorphisms, and B vitamins. The Atherosclerosis Risk in Communities (ARIC) Study
    • Folsom AR, Nieto FJ, McGovern PG et al. Prospective study of coronary artery disease incidence in relation to fasting homocysteine, related genetic polymorphisms, and B vitamins. The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1998; 98: 204-210
    • (1998) Circulation , vol.98 , pp. 204-210
    • Folsom, A.R.1    Nieto, F.J.2    McGovern, P.G.3
  • 14
    • 0942265441 scopus 로고    scopus 로고
    • A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients
    • Kalantar-Zadeh K, Block G, Humphreys MH, McAllister CJ, Kopple JD. A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients. J Am Soc Nephrol 2004; 15: 442-453
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 442-453
    • Kalantar-Zadeh, K.1    Block, G.2    Humphreys, M.H.3    McAllister, C.J.4    Kopple, J.D.5
  • 15
    • 0037337398 scopus 로고    scopus 로고
    • Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
    • Kalanthar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003; 63: 793-808
    • (2003) Kidney Int. , vol.63 , pp. 793-808
    • Kalanthar-Zadeh, K.1    Block, G.2    Humphreys, M.H.3    Kopple, J.D.4
  • 16
    • 8644284226 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: Prospective and case-control studies from the Copenhagen City Heart Study
    • Frederiksen J, Juul K, Grande P et al. Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. Blood 2004; 104: 3046-3051
    • (2004) Blood , vol.104 , pp. 3046-3051
    • Frederiksen, J.1    Juul, K.2    Grande, P.3
  • 17
    • 0942265437 scopus 로고    scopus 로고
    • Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease
    • Wrone EM, Hornberger JM, Zehnder JL et al. Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. J Am Soc Nephrol 2004; 15: 420-426
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 420-426
    • Wrone, E.M.1    Hornberger, J.M.2    Zehnder, J.L.3
  • 18
    • 0034058544 scopus 로고    scopus 로고
    • The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients
    • Kimura H, Gejyo F, Suzuki S, Miyazaki R. The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients. J Am Soc Nephrol 2000; 11: 885-893
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 885-893
    • Kimura, H.1    Gejyo, F.2    Suzuki, S.3    Miyazaki, R.4
  • 19
    • 0036377050 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients
    • Zychma MJ, Gumprecht J, Grzeszczak W, Zukowska-Szczechowska E. Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients. Nephron 2002; 92: 235-239
    • (2002) Nephron , vol.92 , pp. 235-239
    • Zychma, M.J.1    Gumprecht, J.2    Grzeszczak, W.3    Zukowska-Szczechowska, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.