메뉴 건너뛰기




Volumn 63, Issue 5, 2009, Pages 972-976

Comparative in vitro activity of REP3123 against Clostridium difficile and other anaerobic intestinal bacteria

Author keywords

C. difficile infection; Colonization resistance; Normal gut flora

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; CLINDAMYCIN; METRONIDAZOLE; MOXIFLOXACIN; REP 3123; UNCLASSIFIED DRUG; VANCOMYCIN;

EID: 64649101652     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp037     Document Type: Article
Times cited : (35)

References (14)
  • 1
    • 34447542645 scopus 로고    scopus 로고
    • Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States
    • Ricciardi R, Rothenberger DA, Madoff RD et al. Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States. Arch Surg 2007; 142 624-31.
    • (2007) Arch Surg , vol.142 , pp. 624-631
    • Ricciardi, R.1    Rothenberger, D.A.2    Madoff, R.D.3
  • 2
    • 36549073638 scopus 로고    scopus 로고
    • Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027
    • Pepin J, Valiquette L, Gagnon S et al. Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027. Am J Gastroenterol 2007; 102: 2781-8.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2781-2788
    • Pepin, J.1    Valiquette, L.2    Gagnon, S.3
  • 3
    • 33746643774 scopus 로고    scopus 로고
    • New drugs for Clostridium difficile infection
    • Bartlett JG. New drugs for Clostridium difficile infection. Clin Infect Dis 2006; 43: 428-31.
    • (2006) Clin Infect Dis , vol.43 , pp. 428-431
    • Bartlett, J.G.1
  • 4
    • 0141707897 scopus 로고    scopus 로고
    • Antianaerobic antibiotic therapy promotes overgrowth of antibiotic-resistant, Gram-negative bacilli and vancomycin-resistant enterococci in the stool of colonized patients
    • Bhalla A, Pultz NJ, Ray AJ et al. Antianaerobic antibiotic therapy promotes overgrowth of antibiotic-resistant, Gram-negative bacilli and vancomycin-resistant enterococci in the stool of colonized patients. Infect Control Hosp Epidemiol 2003; 24: 644-9.
    • (2003) Infect Control Hosp Epidemiol , vol.24 , pp. 644-649
    • Bhalla, A.1    Pultz, N.J.2    Ray, A.J.3
  • 5
    • 0034727835 scopus 로고    scopus 로고
    • Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients
    • Donskey CJ, Chowdhry TK, Hecker MT et al. Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients. N Engl J Med 2000; 343: 1925-32.
    • (2000) N Engl J Med , vol.343 , pp. 1925-1932
    • Donskey, C.J.1    Chowdhry, T.K.2    Hecker, M.T.3
  • 6
    • 3242772754 scopus 로고    scopus 로고
    • The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
    • Donskey CJ. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis 2004; 39: 219-26.
    • (2004) Clin Infect Dis , vol.39 , pp. 219-226
    • Donskey, C.J.1
  • 8
    • 25844443589 scopus 로고    scopus 로고
    • Antibacterial activity of REP8839, a new antibiotic for topical use
    • Critchley IA, Young CL, Stone KC et al. Antibacterial activity of REP8839, a new antibiotic for topical use. Antimicrob Agents Chemother 2005; 49: 4247-52.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4247-4252
    • Critchley, I.A.1    Young, C.L.2    Stone, K.C.3
  • 9
    • 64649099779 scopus 로고    scopus 로고
    • Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections
    • Critchley IA, Green LS, Young CL et al. Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections. J Antimicrob Chemother 2009; 63: 954-63.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 954-963
    • Critchley, I.A.1    Green, L.S.2    Young, C.L.3
  • 10
    • 64649102420 scopus 로고    scopus 로고
    • Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model
    • Ochsner UA, Bell SJ, O'Leary AL et al. Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model. J Antimicrob Chemother 2009; 63: 964-71.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 964-971
    • Ochsner, U.A.1    Bell, S.J.2    O'Leary, A.L.3
  • 12
    • 25144469664 scopus 로고    scopus 로고
    • Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    • Warny M, Pepin J, Fang A et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 2005; 366 1079-84.
    • (2005) Lancet , vol.366 , pp. 1079-1084
    • Warny, M.1    Pepin, J.2    Fang, A.3
  • 13
    • 7244250115 scopus 로고    scopus 로고
    • Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species
    • Credito KL, Appelbaum PC. Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species. Antimicrob Agents Chemother 2004; 48: 4430-4.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4430-4434
    • Credito, K.L.1    Appelbaum, P.C.2
  • 14
    • 34547640095 scopus 로고    scopus 로고
    • In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004
    • Hecht DW, Galang MA, Sambol SP et al. In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004. Antimicrob Agents Chemother 2007; 51: 2716-9.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2716-2719
    • Hecht, D.W.1    Galang, M.A.2    Sambol, S.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.