Management of brain metastases

Current Neurology and Neuroscience Reports

Volumn 9, Issue 3, 2009, Pages 223-230

  Suh, John H ^a   Chao, Samuel T ^b   Vogelbaum, Michael A ^b  

^a Brain Tumor and Neuro oncology Center   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EFAPROXIRAL; GADOLINIUM TEXAPHYRIN; MELATONIN; THALIDOMIDE;

ADJUVANT THERAPY; BRAIN METASTASIS; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; DRUG SENSITIVITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; HUMAN; HYPOXEMIA; LUNG SMALL CELL CANCER; MORNING DOSAGE; OVERALL SURVIVAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; QUALITY OF LIFE; RADIOSENSITIZATION; REVIEW; STEREOTACTIC RADIOSURGERY; SURVIVAL TIME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; HUMANS; RADIOSURGERY;

EID: 64649099893     PISSN: 15284042     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11910-009-0033-6     Document Type: Review

References (58)

1. Greenberg H, Chandler WF, Sandler HM: Brain metastases. In Brain Tumors. Edited by Greenberg H, Chandler WF, Sandler HM. New York: Oxford University Press; 1999:299-317.
2. Wen PY, Black PM, Loeffler JS: Metastatic brain cancer. In Cancer: Principles and Practice of Oncology. Edited by DeVita V, Hellman S, Rosenberg SA. Philadelphia: Lippincott Williams & Wilkins; 2001:2655-2670.
3. Delattre JY, Krol G, Thaler HT, et al.: Distribution of brain metastases. Arch Neurol 1988, 45:741-744.
4. Nussbaum ES, Djalilian HR, Cho K, et al.: Brain metastases. Histology, multiplicity, surgery and survival. Cancer 1996, 78:1781-1788.
5. Chang EL, Wefel JS, Maor MH, et al.: A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone. Neurosurgery 2007, 60:277-284.
6. Komaki R, Meyers CA, Shin DM, et al.: Evaluation of cognitive function in patients with limited small cell lung cancer prior to and shortly following prophylactic cranial irradiation. Int J Radiat Oncol Biol Phys 1995, 33:179-182.
7. Meyers CA, Smith JA, Bezjak A, et al.: Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial. J Clin Oncol 2004, 22:157-165.
8. Richards P, McKissock W: Intracranial metastases. Br Med J 1963, 5322:15-18.
9. Lang EF, Slater J: Retastatic brain tumors: results of surgical and nonsurgical treatment. Surg Clin North Am 1964, 44:865-872.
10. Chao JH, Phillips R, Nickson JJ: Roentgen-ray therapy of cerebral metastases. Cancer 1954, 7:682-689.
11. Gaspar L, Scott C, Rotman M, et al.: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 1997, 37:745-751.
12. Videtic GM, Adelstein DJ, Mekhail TM, et al.: Validation of the RTOG recursive partitioning analysis (RPA) classification for small cell lung cancer-only brain metastases. Int J Radiat Oncol Biol Phys 2007, 67:240-243.
13. Sperduto PW, Berkey B, Gaspar LE, et al.: A new prognostic index and comparison to three other indices for patients with brain metastases: An analysis of 1960 patients in the RTOG database. Int J Radiat Oncol Biol Phys 2008, 70:510-514.
14. Kurtz JM, Gelber R, Brady LW, et al.: The palliation of brain metastases in a favorable patient population: A randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981, 7:891-895.
15. Borgelt B, Gelber R, Kramer S, et al.: The palliation of brain metastases: Final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1980, 6:1-9.
16. Borgelt B, Gelber R, Larson M, et al.: Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: Final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981, 7:1633-1638.
17. Murray KJ, Scott C, Greenberg HM, et al.: A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: A report of the Radiation Therapy Oncology Group (RTOG) 9104. Int J Radiat Oncol Biol Phys 1997, 39:571-574.
18. DeAngelis, LM, Delattre JY, Posner JB. Radiation-induced dementia in patients cured of brain metastases. Neurology 1989, 39:789-96.
19. Regine WF, Scott C, Murray K, et al.: Neurocognitive outcome in brain metastases patients treated with acceleratedfractionation vs. accelerated-hyperfractionated radiotherapy: An analysis from Radiation Therapy Oncology Group Study 91-04. Int J Radiat Oncol Biol Phys 2001, 51:711-717.
20. Gregor A, Cull A, Stephens RJ, et al.: Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: Results of a multicentre randomised trial. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) and the European Organization for Research and Treatment of Cancer (EORTC). Eur J Cancer 1997, 33:1752-1758.
21. Arriagada R, Le Chevalier T, Borie F, et al.: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst 1995, 87:183-190.
22. van Oosterhout A, Boon P, Houx P, et al.: Follow up of cognitive functioning in patients with small cell lung cancer. Int J Radiat Oncol Biol Phys 1995, 31:911-914.
23. Mehta MP, Rodrigus P, Terhaard CH, et al.: Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 2003, 21:2529-2536.
24. Meyers CA, Weitzner MA, Valentine AD, Levin VA: Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. J Clin Oncol 1998, 16:2522-2527.
25. Shaw EG, Rosdhal R, D'Agostino RB, et al.: Phase II study of donezepil in irradiated brain tumor patients: Effect on cognitive function, mood and quality of life. J Clin Oncol 2006, 24:1415-1420.
26. Gehring K, Sitskoorn MM, Aaronson NK, et al.: Interventions for cognitive deficits in adult with brain tumours. Lancet Neurol 2008, 7:548-560.
27. Peissner W, Kocher M, Treuer H, et al.: Ionizing radiationinduced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res 1999, 71:61-68.
28. Mizumatsu S, Monje ML, Morhardt DR, et al.: Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res 2003, 63:4021-4027.
29. Ghia A, Tome WA, Thomas S, et al.: Distribution of brain metastasis in relation to the hippocampus: Implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys 2007, 68:971-977.
30. Khuntia D, MehtaAM: Motexafin gadolinium: a clinical review of a novel radioenhancer for brain tumors. Expert Rev Anticancer Ther 2004, 4:981-989.
31. Carde P, Timmerman R, Mehta MP, et al.: Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases. J Clin Oncol 2001, 19:2074-2083.
32. Mehta MP, Shapiro WR, Glantz MJ, et al.: Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: Centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points. J Clin Oncol 2002, 20:3445-3453.
33. Mehta MP, Carrie C, Mahe MA, et al.: Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Results of a randomized phase 3 trial. Int J Radiat Oncol Biol Phys 2006, 66(Suppl):S23.
34. Kunert M, Liard J, Abraham D: RSR-13, an allosteric effector of hemoglobin, increases systemic and iliac vascular resistance in rats. Am J Physiol 1996, 271:H602-H613.
35. Suh J: Afaproxiral: a novel radiation sensitizer. Expert Opin Investig Drugs 2004, 13:543-550.
36. Shaw E, Scott C, Suh J, et al.: RSR-13 plus cranial radiation therapy in patients with brain metastases: Comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database. J Clin Oncol 2003, 21:2364-2371.
37. Suh JH, Stea B, Nabid A, et al.: Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases. J Clin Oncol 2006, 24:106-114.
38. Suh JH, Stea B, Nabid A, et al.: Results of the phase III ENRICH (RT-016) study of efaproxiral administered concurrent with whole brain radiation therapy (WBRT) in women with brain metastases from breast cancer. Int J Radiat Oncol Biol Phys 2008, 72(Suppl):S110.
39. Berk L, Berkey B, Rich T, et al.: Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119). Int J Radiat Oncol Biol Phys 2007, 68:852-857.
40. D'Amato RJ, Loughnan MS, Flynn E, et al.: Thalidomide is an inhibitor of angiogenesis. Proc Nat Acad Sci U S A 1994, 91:4082-4085.
41. Knisely JP, Berkey B, Chakravarti A, et al.: A phase III study of conventional radiation therapy plus thalidomide versus conventional radiation therapy for multiple brain metastases (RTOG 0118). Int J Radiat Oncol Biol Phys 2008, 71:79-86.
42. Patchell RA, Tibbs PA, Walsh JW, et al.: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990, 322:494-500.
43. Vecht CJ, Haaxma-Reiche H, Noordijk EM, et al.: Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery. Ann Neurol 1993, 33:583-590.
44. Mintz AH, Kestle J, Rathbone MP, et al.: A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 1996, 78:1470-1476.
45. Patchell RA, Tibbs PA, Regine WF, et al.: Postoperative radiotherapy in the treatment of single metastases to the brain: A randomized trial. JAMA 1998, 280:1485-1489.
46. Shaw E, Scott C, Souhami L, et al.: Single dose radiosurgical treatment of recurrent irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys 2000, 47:291-298.
47. Sanghavi SN, Miranpuri SS, Chappell R, et al.: Radiosurgery for patients with brain metastases: A multiinstitutional analysis, stratified by the RTOG recursive partitioning analysis method. Int J Radiat Oncol Biol Phys 2001, 51:426-434.
48. Andrews DW, Scott CB, Sperduto PW, et al.: Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial. Lancet 2004, 363:1665-1672.
49. Kondziolka D, Patel A, Lunsford LD, et al.: Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 1999, 45:427-434.
50. Sneed P, Suh J, Goetsch S, et al.: A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 2002, 53:519-526.
51. Pirzkall A, Debus J, Lohr F, et al.: Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol 1998, 16:3563-3569.
52. Manon R, O'Neill A, Knisely J, et al.: Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: An Eastern Cooperative Oncology Group study (E 6397). J Clin Oncol 2005, 23:8870-8876.
53. Aoyama H, Shirato H, Tago M, et al.: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial. JAMA 2006, 295:2483-2491.
54. Aoyama H, Tago M, Kato N, et al.: Neurocognitive function of patients with brain metastases who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. Int J Radiat Oncol Biol Phys 2007, 68:1388-1395.
55. Kim PL, Ellis TL, Stieber VW, et al.: Gamma knife surgery targeting the resection cavity of brain metastasis that has progressed after whole-brain radiotherapy. J Neurosurg (Suppl) 2006, 105:75-78.
56. Soltys SG, Adler JR, Lipani JD, et al.: Stereotactic radiosurgery of the postoperative resection cavity for brain metastases. Int J Radiat Oncol Biol Phys 2008, 70:187-193.
57. Chao ST, Barnett GH, Liu SW, et al.: Five-year survivors of brain metastases: A single-institution report of 32 patients. Int J Radiat Oncol Biol Phys 2006, 66:801-809.
58. Kondziolka D, Martin JJ, Flickinger JC, et al.: Longterm survivors after gamma knife radiosurgery for brain metastases. Cancer 2005, 104:2784-2791.