Monosodium Glutamate

Food Allergy: Adverse Reactions to Foods and Food Additives, Fourth Edition

Volumn , Issue , 2009, Pages 369-376

  Woessner, Katharine M ^a  

^a SCRIPPS CLINIC   (United States)

Author keywords

Fifth taste L glutamate; Monosodium glutamate (MSG); Monosodium glutamate and neurotoxicity; MSG and food and drug administration; MSG food labeling; MSG symptom complex; Urticaria and angioedema

Indexed keywords

EID: 64649090312     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444300062.ch30     Document Type: Chapter

References (67)

1. Kwok R. Chinese restaurant syndrome. N Engl J Med 1968;178:796.
2. Yamaguchi S. Fundamental Properties of Umami in Human Taste Sensation. New York: Marcel Dekker, 1987.
3. Ikeda K. On the taste of the salt of glutamic acid (new seasonings). J Tokyo Chem Soc 1909:820-36.
4. Schultz W. Food labeling; declaration of free glutamate in food. Federal Register, 21 CFR Past 101 [Docket No 96N-0244]. 1996;61:48102-10.
5. Filer Jr LJ, Stegink LD. A report of the proceedings of an MSG workshop held August 1991. Crit Rev Food Sci Nutr 1994;34:159-74.
6. Meisler A. Biochemistry of glutamate, glutamine and glutathione. In: Filer LJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds.) Glutamic Acid: Advances in Biochemistry and Physiology. New York: Raven Press, 1979:69-84.
7. Stegink LD, Bell E, Daabees TT, et al. Factors influencing utilization of glycine, glutamate and aspartate in clinical products. In: Blackburn GL, Grant JP Young VR (eds.) Amino Acids: Metabolism and Medical Applications. MA: John Wrist, 1983:123-41.
8. Filer LJ, Stegink LD (eds.). A report of the proceedings of a MSG workshop held August 1991. Clin Rev Food Sci Nutr 1991;34:159-74.
9. Stegink LD, Baker, GL. Monosodium glutamate: effect of plasma and breast milk levels in lactating women. Proc Soc Exp Biol Med 1972;140:836-41.
10. Stegink LD, Pitkin, RM, Reynolds, WA, et al. Placental transfer of glutamate and its metabolites in the primate. Am J Obstet Gynecol 1975;122:70-8.
11. Tung TC, Tung TS. Serum free amino acid levels after oral glutamate intake in infant and adult humans. Nutr Rep Int 1980;22:431-43.
12. Agostoni C, Carratu B, Boniglia C, et al. Free amino acid content in standard infant formulas: comparison with human milk. J Am Coll Nutr 2000;19:434-8.
13. Agostoni C, Jochum F, Meinardus P, et al. Total glutamine content in preterm and term human breast milk. Acta Paediatr 2006;95:985-90.
14. Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969;164:719-21.
15. Olney JW, Sharpe, LG. Brain lesions in an infant rhesus monkey treated with monosodium glutamate. Science 1969;166:386-8.
16. Olney JW, Sharpe, LG, Fergin, LD. Glutamate-induced brain damage in infant primates. JNeuropathol Exp Neurol 1972;31:464-88.
17. Walker R, Lupien JR. The safety evaluation of monosodium glutamate. J Nutr 2000;130:1049S-52S.
18. Wakabayashi I, Hatano, H, Minami, S, et al. Effects of neonatal monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats. Brain Res 1986;372:361-6.
19. Olney JW, Cicero TJ, Meyer ER, et al. Acute glutamate-induced elevations in serum testosterone and leutenizing hormone. Brain Res 1976;112:420-4.
20. Morikyi HIM. Acute toxicity of monosodium L-glutamate in mice and rats. Pharmacometrics 1979;5:433-6.
21. Ebert AG. Adverse effects of monosodium glutamate. J Asthma 1983;20:159-64.
22. Shibata MA, Tanaka H, Kawabe M, et al. Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Food Chem Toxicol 1995;33:383-91.
23. Ebert AG. The dietary administration of monosodium glutamate or glutamic acid to c-57 black mice for two years. Toxicol Lett 1979b;3:65-70.
24. Ebert AG. The dietary administration of L-monosodium glutamate, DL-monosodium glutamate and L-gluatmic acid to rats. Toxicol Lett 1979a;3:71-8.
25. Ishidate Jr MST, Yoshikawa K, Hayashi M, et al. Primary mutagenicity screening of food additives currently used in Japan. Food Chem Toxicol 1984;22:623-36.
26. Owen G, Cherry CP, Prentice DE, Worden, AN. The feeding of diets containing up to 10% MSG to beagle dogs for two years. Toxicol Lett 1978;1:217-19.
27. WHO. L-Glutamic acid and its ammonium, calcium, and monosodium and potassium salts. Toxicological Evaluation of Certain Food Additives 31st Meeting of the Joint FAO/WHO Expert Committee on Food Additives. New York: Cambridge University Press, 1988:97-161.
28. Settipane GA. The restaurant syndromes. NEngl Reg Allergy Proc 1987;8:39-46.
29. Schaumburg HH, Byck R. Sin cib-syn: accent on glutamate. N Engl J Med 1968;279:105.
30. Tarasoff L, Kelly ME. Monosodium L-glutamate: a double-blind study and review. Food Chem Toxicol 1993;31:1019-35.
31. Schaumburg HH, Byck R, Gerstl R, et al. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science 1969;163:826-8.
32. Kenney RA. Placebo controlled studies of human reaction to oral monosodium L-glutamate. In: Filer LJ, Garattini S, Kare MR, Reynolds WA,Wurtman RJ (eds.) Glutamic Acid: Advances in Biochemistry and Physiology. New York: Raven Press, 1979:363-73.
33. Kenney RA, Tidball CS. Human susceptibility to oral monosodium L-glutamate. Am J Clin Nutr 1972;25:140-6.
34. Morselli PL, Garattini, S. Monosodium glutamate and the Chinese restaurant syndrome. Science 1979;227:611-12.
35. Zanda G, Eranciosi P, Tognoni G, et al. A double blind study on the effects of monosodium glutamate in man. Biomedicine 1973;10;19:202-4.
36. Geha RS, Beiser A, Ren C, et al. Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol 2000;106:973-80.
37. Geha RS, Beiser A, Ren C, et al. Review of alleged reaction to monosodium glutamate and outcome of a multicenter doubleblind placebo-controlled study. J Nutr 2000;130:1058S-62S.
38. Raiten DJ, Talbo, JM, Eisher KD. Analysis of Adverse Reactions to Monosodium Glutamate (MSG). American Institute of Nutrition, Bethesda MD 1995.
39. Reif-Lehrer L. A questionnaire study of the prevalence Chinese restaurant syndrome. Fed Am Soc Exp Biol 1977;36:1617-23.
40. Kerr GR, Wu-Lee M, El-Lozy M, et al. Objectivity of food-symp-tomatology surveys. Questionnaire on the "Chinese restaurant syndrome". J Am Diet Assoc 1977;71:263-8.
41. Kerr GR, Wu-Lee M, El-Lozy M, et al. Food symptomatology questionnaires: risks of demand-bias questions and population-based surveys. In: Filer LJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds.) Glutamic Acid: Advances in Biochemistry and Physiology. New York: Raven Press, 1979:375-87.
42. Ghadimi H, Kumar S, Abaci F. Studies on monosodium glutamate ingestion. I. Biochemical explanation of the Chinese restaurant syndrome. Biochem Med 1971;5:447-56.
43. Gajalakshmi BS, Thiagarajan C, Yahya GM. Parasympathomimetic effects of monosodium glutamate. Indian J Physiol Pharmacol 1977;21:55-8.
44. Folkers K, Shizukuishi S, Willis R, et al. The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome. Hoppe Seylers Z Physiol Chem 1984;365:405-14.
45. Folkers K, Shizukuishi S, Scudder SL, et al. Biochemical evidence for a deficiency of vitamin B6 in subjects reacting to monosodium L-glutamate by the Chinese restaurant syndrome. Biochem Biophys Res Commun 1981;100:972-7.
46. Scher W, Scher BM. A possible role for nitric oxide in glutamate (MSG)-induced Chinese restaurant syndrome, glutamate-induced asthma, "hot-dog headache", pugilistic Alzheimer's disease and other disorders. Med Hypotheses 1992;38:185-8.
47. Nguyen-Duong J. Vasorelaxation induced by L-glutamate in porcine coronary arteries. J Toxicol Environ Health 2001;62:643-53.
48. Allen DH, Baker GJ. Chinese restaurant asthma. N Engl J Med 1981;278:796.
49. Allen DH, Delohery J, Baker G. Monosodium L-glutamate-induced asthma. J Allergy Clin Immunol 1987;80:530-7.
50. Stevenson DD. Monosodium glutamate and asthma. J Nutr 2000;130:1067S-73S.
51. Schwartzstein RM, Kelleher M, Weinberger SE, et al. Airway effects of monosodium glutamate in subjects with chronic stable asthma. J Asthma 1987;24:167-72.
52. Moneret-Vautrin DA. Monosodium glutamate-induced asthma: study of the potential risk of 30 asthmatics and review of the literature. Allerg Immunol (Paris) 1987;19:29-35.
53. Germano P, Cohen SG, Hahn B, et al. An evaluation of clinical reactions to monosodium glutamate (MSG) in asthmatics, using a blinded, placebo-controlled challenge. J Allergy Clin Immunol 1991;87:177.
54. Woods RK, Weiner JM, Thien F, et al. The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate-intolerant. J Allergy Clin Immunol 1998;101:762-71.
55. Woessner KM, Simon RA, Stevenson DD. Monosodium glutamate sensitivity in asthma. J Allergy Clin Immunol 1999;104:305-10.
56. Squire Jr EN. Angio-oedema and monosodium glutamate. Lancet 1987;25;1:988.
57. Genton C, Frei PC, Pecond A. Value of oral provocation tests to aspirin and food additives in the routine investigation of asthma and chronic urticaria. J Allergy Clin Immunol 1985;76:40-5.
58. Supramaniam G, Werner JO. Artificial food additive intolerance in patients with angio-edema and urticaria. Lancet 1986;2:907-9.
59. Botey J, Cozzo M, Marin A, et al. Monosodium glutamate and skin pathology in pediatric allergology. Allergol Immunopathol (Madr) 1988;16:425-8.
60. Simon RA. Additive-induced urticaria: experience with monosodium glutamate (MSG). J Nutr 2000;130:1063S-6S.
61. Gray D. Food and Drug Administration Memorandum, Glutamate in Food. Federal Register 1996;61:48102-10.
62. Ratner D, Eshel E, Shoshani E. Adverse effects of monosodium glutamate: a diagnostic problem. Isr J Med Sci 1984;20:252-3.
63. Scopp AL. MSG and hydrolyzed vegetable protein induced headache: review and case studies. Headache 1991;31:107-10.
64. Yang WH, Drouin MA, Herbert M, et al. The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol 1997;99:757-62.
65. Merritt JE, Williams PB. Vasospasm contributes to monosodium glutamate-induced headache. Headache 1990;30:575-80.
66. Hattan GG. Evaluation of the Federation of American Societies for Experimental Biology (FASEB) July 1995 Report: Analysis of adverse reactions to monosodium glutamate (MSG). Memorandum from the Director of Health Effects Evaluation to Dr Lawrence Lin: HFS-206; 1996.
67. FASEB. Analysis of Adverse Reactions to Monosodium Glutamate (MSG) Report. Washington, DC: Life Sciences Research Office, Federation of American Societies for Experimental Biology, 1995.