The monosodium glutamate symptom complex: Assessment in a double-blind, placebo-controlled, randomized study

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 6 I SUPPL., 1997, Pages 757-762

  Yang, W H ^a   Drouin, M A ^a   Herbert, M ^a   Mao, Y ^a   Karsh, J ^a  

^a NONE   (Canada)

Author keywords

Monosodium glutamate; Monosodium glutamate symptom complex; Randomized double blind challenge

Indexed keywords

GLUTAMATE SODIUM;

ALLERGIC REACTION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FLUSHING; FOOD ALLERGY; HEADACHE; HUMAN; HUMAN CELL; HUMAN TISSUE; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MUSCLE WEAKNESS; ORAL DRUG ADMINISTRATION; PARESTHESIA; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SKIN TINGLING;

EID: 0030981188     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)80008-5     Document Type: Article

References (43)

1. [Letter] Kwok RHM Chinese restaurant syndrome N Engl J Med 278 1968 796
2. [Letter] Allen DH Baker GJ Chinese restaurant asthma N Engl J Med 305 1981 1154 1155
3. Allen DH Delohery MB Baker GJ Monosodium l -glutamate-induced asthma J Allergy Clin Immunol 80 1987 530 537
4. [Letter] Hosen H Airway effects of MSG Asthma 25 1988 111
5. Moneret-Vautrin DA Monosodium glutamate-induced asthma: study of the potential risk in 30 asthmatics and review of the literature Allerg Immunol 19 1987 29 35
6. Randolph TG Rollins JP Beet sensitivity: allergic reactions from the ingestion of beet sugar (sucrose) and monosodium glutamate of beet origin J Lab Clin Med 36 1950 407 417
7. Ratner D Eshel E Shoshani E Adverse effects of monosodium glutamate: a diagnostic problem Israel J Med Sci 20 1984 252 253
8. Van Bever HP Docx M Stevens WJ Food and food additives in severe atopic dermatitis Allergy 44 1989 588 594
9. Freed DLJ Carter R Neuropathy due to monosodium glutamate intolerance Ann Allergy 48 1982 96 97
10. Oliver AJ Rich AM Reade PC Varigos GA Radden BG Monosodium glutamate-related orofacial granulomatosis Oral Surg Oral Med Oral Pathol 71 1991 560 564
11. Sweatman MC Tasker R Warner JO Ferguson MM Mitchell DN Oro-facial granulomatosis: response to elemental diet and provocation by food additives Clin Allergy 16 1986 331 338
12. [Letter] Coleman AD Possible psychiatric reactions to monosodium glutamate N Engl J Med 299 1978 902
13. [Letter] Goldberg LH Supraventricular tachyarrhythmia in association with the Chinese restaurant syndrome Ann Emerg Med 11 1982 333
14. Gann D Ventricular tachycardia in a patient with the “Chinese restaurant syndrome South Med J 70 1977 879 881
15. Reif-Lehrer L Possible significance of adverse reactions to glutamate in humans Fed Proc 35 1976 2205 2212
16. ReifLehrer L A questionnaire study of the prevalence of Chinese restaurant syndrome Fed Proc 36 1977 1617 1623
17. [Letter] Schaumburg H Chinese restaurant syndrome N Engl J Med 278 1968 1122
18. [Letter] Rath J Chinese restaurant syndrome N Engl J Med 278 1968 1123
19. [Letter] Gordon ME Chinese restaurant syndrome N Engl J Med 278 1968 1123 1124
20. [Letter] McCaghren TJ Chinese restaurant syndrome N Engl J Med 278 1968 1123
21. [Letter] Schaumburg HH Byck R Sin Cib-Syn: accent on glutamate N Engl J Med 279 1968 105
22. Kenney RA Tidball CS Human susceptibility to oral monosodium l -glutamate Am J Clin Nutr 25 1972 140 146
23. [Letter] Reif-Lehrer L Monosodium glutamate intolerance in children N Engl J Med 293 1975 1204 1205
24. [Letter] Gore MR Salmon PR Chinese restaurant syndrome: fact or fiction? Lancet i 1980 251 252
25. Asnes RS Chinese restaurant syndrome in an infant Clin Pediatr 19 1980 705 706
26. [Letter] Smith JS Markandu ND Rotellar C Elder DM MacGregor GA A new or old Chinese restaurant syndrome? BMJ 285 1982 1205
27. Bender AE Matthews DR Adverse reactions to foods Br J Nutr 46 1981 403 407
28. Simon RA Adverse reactions to food additives NER Allergy Proc 7 1986 533 542
29. Kenney RA Placebo-controlled studies of human reaction to oral monosodium l -glutamate Filner IJ Jr Garattini S Kare MR Reynolds WA Wurtman RJ Glutamic acid: advances in biochemistry and physiology 1979 Raven New York 363 373
30. Rosenblum I Bradley JD Coulston F Single and double blind studies with oral monosodium glutamate in man Toxicol Appl Pharmacol 18 1971 367 373
31. Zanda G Franciosi P Tognoni G A double blind study on the effects of monosodium glutamate in man Biomedicine 19 1973 202 204
32. Tanphaichitr V Srianujata S Pothisiri P Sammasut R Kukapongse S Postprandial responses to Thai foods with and without added monosodium l -glutamate Nutr Rep Int 28 1983 783 792
33. Tarasoff L Kelly M Monosodium l -glutamate: a double blind study and review Food Chem Toxicol 31 1993 1019 1035
34. Life Sciences Research Office of FASEB Raiten DJ Talbot JM Fisher KD Analysis of adverse reactions to monosodium glutamate 1995 FASEB Bethesda, Maryland
35. Kerr GR Wu-Lee M El-Lozy M McGandy R Stare FJ Food-symptomology questionnaires: risks of demand-bias questions and population-biased surveys Filner LJ Jr Garattini S Kare MR Reynolds WA Wurtman RJ Glutamic acid: advances in biochemistry and physiology 1979 Raven New York 375 387
36. Kerr GR Wu-Lee M El-Lozy M McGandy R State FJ Prevalence of the “Chinese restaurant syndrome J Am Diet Assoc 75 1979 29 33
37. Kenney RA The Chinese restaurant syndrome: an anecdote revisited Food Chem Toxicol 24 1986 351 354
38. Folkers K Shizukuishi S Wills R Scudder SL Takemura K Longenecker JB The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome Hoppe-Seyler's Z Physiol Chem 365 1984 405 414
39. Henne-Kens CH Buring JE Epidemiology in medicine 1987 Little, Brown New York 192 195
40. Peace KE Statistical issues in drug research and development Stat Textbooks Monographs 106 1990 27 168
41. Rosenzwig P Brohier S Zipfel A The placebo effect in healthy volunteers: influence of experimental conditions on adverse events profile during phase I studies Clin Pharmacol Ther 54 1993 578 583
42. Geha R Buckley CE Greenberger P Aspartame is no more likely than placebo to cause urticaria/angioedema: results of a multicenter randomized, double-blind, placebo-controlled, crossover study J Allergy Clin Immunol 92 1993 513 520
43. Stegink LD Filner LJ Jr Baker GL Mueller SM Wu-Rideout MY Factors affecting plasma glutamate levels in normal adult subjects Filner LJ Jr Garattini S Kare MR Reynolds WA Wurtman RJ Glutamic acid: advances in biochemistry and physiology 1979 Raven New York 333 351