메뉴 건너뛰기




Volumn 1160, Issue , 2009, Pages 294-299

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

Author keywords

Cell signaling; Myofibroblast; Relaxin; Transforming growth factor 1; Tubulointerstitial fibrosis; smooth muscle actin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; RECOMBINANT H2 RELAXIN; RECOMBINANT PROTEIN; RELAXIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 64549156507     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03823.x     Document Type: Conference Paper
Times cited : (7)

References (34)
  • 1
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • Wynn, T.A. 2007. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 117: 524-529.
    • (2007) J. Clin. Invest , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 2
    • 33846573898 scopus 로고    scopus 로고
    • Fibroblast differentiation in wound healing and fibrosis
    • Darby, I.A. & T.D. Hewitson. 2007. Fibroblast differentiation in wound healing and fibrosis. Int. Rev. Cytol. 257: 143-179.
    • (2007) Int. Rev. Cytol , vol.257 , pp. 143-179
    • Darby, I.A.1    Hewitson, T.D.2
  • 3
    • 25444441069 scopus 로고    scopus 로고
    • Progression in chronic kidney disease
    • Eddy, A.A. 2005. Progression in chronic kidney disease. Adv. Chronic Kidney Dis. 12: 353-365.
    • (2005) Adv. Chronic Kidney Dis , vol.12 , pp. 353-365
    • Eddy, A.A.1
  • 4
    • 33646522213 scopus 로고    scopus 로고
    • Relaxin in cardiovascular and renal disease
    • Samuel, C.S. & T.D. Hewitson. 2006. Relaxin in cardiovascular and renal disease. Kidney Int. 69: 1498-1502.
    • (2006) Kidney Int , vol.69 , pp. 1498-1502
    • Samuel, C.S.1    Hewitson, T.D.2
  • 6
    • 33846453635 scopus 로고    scopus 로고
    • Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis
    • Hewitson, T.D., I. Mookerjee, R. Masterson, et al. 2007. Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis. Endocrinology 148: 660-669.
    • (2007) Endocrinology , vol.148 , pp. 660-669
    • Hewitson, T.D.1    Mookerjee, I.2    Masterson, R.3
  • 7
    • 0041428208 scopus 로고    scopus 로고
    • Inhibition of markers of hepatic stellate cell activation by the hormone relaxin
    • Bennett, R.G., K.K. Kharbanda & D.J. Tuma. 2003. Inhibition of markers of hepatic stellate cell activation by the hormone relaxin. Biochem. Pharmacol. 66: 867-874. 8.
    • (2003) Biochem. Pharmacol , vol.66 , Issue.867-874 , pp. 8
    • Bennett, R.G.1    Kharbanda, K.K.2    Tuma, D.J.3
  • 8
    • 4344606223 scopus 로고    scopus 로고
    • Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo
    • Samuel, C.S., E.N. Unemori, I. Mookerjee, et al. 2004. Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145: 4125-4133.
    • (2004) Endocrinology , vol.145 , pp. 4125-4133
    • Samuel, C.S.1    Unemori, E.N.2    Mookerjee, I.3
  • 9
    • 1342285008 scopus 로고    scopus 로고
    • Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro
    • Masterson, R., T.D. Hewitson, K. Kelynack, et al. 2004. Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol. Dial. Transplant. 19: 544-552.
    • (2004) Nephrol. Dial. Transplant , vol.19 , pp. 544-552
    • Masterson, R.1    Hewitson, T.D.2    Kelynack, K.3
  • 10
    • 24944542890 scopus 로고    scopus 로고
    • The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
    • Heeg, M.H., M.J. Koziolek, R. Vasko, et al. 2005. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int. 68: 96-109.
    • (2005) Kidney Int , vol.68 , pp. 96-109
    • Heeg, M.H.1    Koziolek, M.J.2    Vasko, R.3
  • 11
    • 0042704734 scopus 로고    scopus 로고
    • Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells
    • Hayashida, T., M. Decaestecker & H.W. Schnaper. 2003. Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEBJ. 17: 1576-1578.
    • (2003) FASEBJ , vol.17 , pp. 1576-1578
    • Hayashida, T.1    Decaestecker, M.2    Schnaper, H.W.3
  • 12
    • 0032824798 scopus 로고    scopus 로고
    • The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells
    • Poncelet, A.C., M.P. de Caestecker & H.W. Schnaper. 1999. The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int. 56:1354-1365.
    • (1999) Kidney Int , vol.56 , pp. 1354-1365
    • Poncelet, A.C.1    de Caestecker, M.P.2    Schnaper, H.W.3
  • 13
    • 33745226248 scopus 로고    scopus 로고
    • Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms
    • Halls, M.L., R.A. Bathgate & R.J. Summers. 2006. Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. Mol. Pharmacol. 70: 214-226.
    • (2006) Mol. Pharmacol , vol.70 , pp. 214-226
    • Halls, M.L.1    Bathgate, R.A.2    Summers, R.J.3
  • 14
    • 23644433831 scopus 로고    scopus 로고
    • Relaxin stimulates multiple signaling pathways: Activation of cAMP, PI3K, and PKCζ in THP-1 cells
    • Dessauer, C.W. & B.T. Nguyen. 2005. Relaxin stimulates multiple signaling pathways: Activation of cAMP, PI3K, and PKCζ in THP-1 cells. Ann. N. Y. Acad. Sci. 1041: 272-279.
    • (2005) Ann. N. Y. Acad. Sci , vol.1041 , pp. 272-279
    • Dessauer, C.W.1    Nguyen, B.T.2
  • 15
    • 33749599788 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3-kinase and mTOR pathways in the regulation of renal fibroblast function and differentiation
    • Winbanks, C.E., L. Grimwood, A. Gasser, et al. 2007. Role of the phosphatidylinositol 3-kinase and mTOR pathways in the regulation of renal fibroblast function and differentiation. Int. J. Biochem. Cell. Biol. 39: 206-219.
    • (2007) Int. J. Biochem. Cell. Biol , vol.39 , pp. 206-219
    • Winbanks, C.E.1    Grimwood, L.2    Gasser, A.3
  • 16
    • 0036242761 scopus 로고    scopus 로고
    • Relaxin activates the MAP kinase pathway in human endometrial stromal cells
    • Zhang, Q., S.H. Liu, M. Erikson, et al. 2002. Relaxin activates the MAP kinase pathway in human endometrial stromal cells. J. Cell. Biochem. 85: 536-544.
    • (2002) J. Cell. Biochem , vol.85 , pp. 536-544
    • Zhang, Q.1    Liu, S.H.2    Erikson, M.3
  • 17
    • 23644444636 scopus 로고    scopus 로고
    • Myocardial relaxin counteracts hypertrophy in hypertensive rats
    • Dschietzig, T., C. Bartsch, T. Kinkel, et al. 2005. Myocardial relaxin counteracts hypertrophy in hypertensive rats. Ann. N. Y. Acad. Sci. 1041: 441-443.
    • (2005) Ann. N. Y. Acad. Sci , vol.1041 , pp. 441-443
    • Dschietzig, T.1    Bartsch, C.2    Kinkel, T.3
  • 18
    • 0037428061 scopus 로고    scopus 로고
    • Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: Attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-κB
    • Dschietzig, T., C. Bartsch, C. Richter, et al. 2003. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-κB. Circ. Res. 92: 32-40.
    • (2003) Circ. Res , vol.92 , pp. 32-40
    • Dschietzig, T.1    Bartsch, C.2    Richter, C.3
  • 19
    • 34247639085 scopus 로고    scopus 로고
    • Relaxin as a cardiovascular hormone: Physiology, pathophysiology and therapeutic promises
    • Nistri, S., M. Bigazzi & D. Bani. 2007. Relaxin as a cardiovascular hormone: Physiology, pathophysiology and therapeutic promises. Cardiovasc. Hematol. Agents Med. Chem. 5: 101-108.
    • (2007) Cardiovasc. Hematol. Agents Med. Chem , vol.5 , pp. 101-108
    • Nistri, S.1    Bigazzi, M.2    Bani, D.3
  • 21
    • 1442323685 scopus 로고    scopus 로고
    • Relaxin inhibits the activation of human neutrophils: Involvement of the nitric oxide pathway
    • Masini, E., S. Nistri, A. Vannacci, et al. 2004. Relaxin inhibits the activation of human neutrophils: Involvement of the nitric oxide pathway. Endocrinology 145: 1106-1112.
    • (2004) Endocrinology , vol.145 , pp. 1106-1112
    • Masini, E.1    Nistri, S.2    Vannacci, A.3
  • 22
    • 33645342475 scopus 로고    scopus 로고
    • Cardiac anaphylaxis: Pathophysiology and therapeutic perspectives
    • Bani, D., S. Nistri, P.F. Mannaioni, et al. 2006. Cardiac anaphylaxis: Pathophysiology and therapeutic perspectives. Curr. Allergy Asthma Rep. 6: 14-19.
    • (2006) Curr. Allergy Asthma Rep , vol.6 , pp. 14-19
    • Bani, D.1    Nistri, S.2    Mannaioni, P.F.3
  • 23
    • 33749265164 scopus 로고    scopus 로고
    • Relaxin' the stiffened heart and arteries: The therapeutic potential for relaxin in the treatment of cardiovascular disease
    • Samuel, C.S., X.J. Du, R.A.D. Bathgate, et al. 2006. 'Relaxin' the stiffened heart and arteries: The therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharmacol. Ther. 112: 529-552.
    • (2006) Pharmacol. Ther , vol.112 , pp. 529-552
    • Samuel, C.S.1    Du, X.J.2    Bathgate, R.A.D.3
  • 24
    • 0036190726 scopus 로고    scopus 로고
    • Relaxin depresses small bowel motility through a nitric oxide-mediated mechanism. Studies in mice
    • Bani, D., M.C. Baccari, S. Quattrone, et al. 2002. Relaxin depresses small bowel motility through a nitric oxide-mediated mechanism. Studies in mice. Biol. Reprod. 66: 778-784.
    • (2002) Biol. Reprod , vol.66 , pp. 778-784
    • Bani, D.1    Baccari, M.C.2    Quattrone, S.3
  • 25
    • 34547630675 scopus 로고    scopus 로고
    • Reversal by relaxin of altered ileal spontaneous contractions in dystrophic (mdx) mice through a nitric oxide-mediated mechanism
    • Baccari, M.C., S. Nistri, M.G. Vannucchi, et al. 2007. Reversal by relaxin of altered ileal spontaneous contractions in dystrophic (mdx) mice through a nitric oxide-mediated mechanism. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293: R662-R668.
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.293
    • Baccari, M.C.1    Nistri, S.2    Vannucchi, M.G.3
  • 26
    • 12944300989 scopus 로고    scopus 로고
    • Studies of cervical ripening in pregnant rats: Effects of various treatments
    • Shi, L., S.Q. Shi, G.R. Saade, et al. 2000. Studies of cervical ripening in pregnant rats: Effects of various treatments. Mol. Hum. Reprod. 6: 382-389.
    • (2000) Mol. Hum. Reprod , vol.6 , pp. 382-389
    • Shi, L.1    Shi, S.Q.2    Saade, G.R.3
  • 27
    • 35648943682 scopus 로고    scopus 로고
    • A novel, simple bioactivity assay for relaxin based on inhibition of platelet aggregation
    • Bani, D., S. Nistri, L. Cinci, et al. 2007. A novel, simple bioactivity assay for relaxin based on inhibition of platelet aggregation. Regul. Pept. 144: 10-16.
    • (2007) Regul. Pept , vol.144 , pp. 10-16
    • Bani, D.1    Nistri, S.2    Cinci, L.3
  • 28
    • 34247884253 scopus 로고    scopus 로고
    • Relaxininduced matrix metalloproteinase-9 expression is associated with activation of the NF-κB pathway in human THP-1 cells
    • Ho, T.Y., W. Yan & C.A. Bagnell. 2007. Relaxininduced matrix metalloproteinase-9 expression is associated with activation of the NF-κB pathway in human THP-1 cells. J. Leukoc. Biol. 81: 1303-1310.
    • (2007) J. Leukoc. Biol , vol.81 , pp. 1303-1310
    • Ho, T.Y.1    Yan, W.2    Bagnell, C.A.3
  • 29
    • 4344564007 scopus 로고    scopus 로고
    • Relaxin receptors and nitric oxide synthases: Search for the missing link
    • Nistri, S. & D. Bani. 2003. Relaxin receptors and nitric oxide synthases: Search for the missing link. Reprod. Biol. Endocrinol. 1: 5.
    • (2003) Reprod. Biol. Endocrinol , vol.1 , pp. 5
    • Nistri, S.1    Bani, D.2
  • 30
    • 0037169071 scopus 로고    scopus 로고
    • Activation of orphan receptors by the hormone relaxin
    • Hsu, S.Y., K. Nakabayashi, S. Nishi, et al. 2002. Activation of orphan receptors by the hormone relaxin. Science 295: 671-674.
    • (2002) Science , vol.295 , pp. 671-674
    • Hsu, S.Y.1    Nakabayashi, K.2    Nishi, S.3
  • 31
    • 2442647519 scopus 로고    scopus 로고
    • Relaxin-1-deficient mice develop an age-related progression of renal fibrosis
    • Samuel, C.S., C. Zhao, C.P. Bond, et al. 2004. Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Kidney Int. 65: 2054-2064.
    • (2004) Kidney Int , vol.65 , pp. 2054-2064
    • Samuel, C.S.1    Zhao, C.2    Bond, C.P.3
  • 32
    • 33644589069 scopus 로고    scopus 로고
    • International Union of Pharmacology: Recommendations for the nomenclature of receptors for relaxin family pep tides
    • Bathgate, R.A., R. Ivell, B.M. Sanborn, et al. 2006. International Union of Pharmacology: Recommendations for the nomenclature of receptors for relaxin family pep tides. Pharmacol. Rev. 58: 7-31.
    • (2006) Pharmacol. Rev , vol.58 , pp. 7-31
    • Bathgate, R.A.1    Ivell, R.2    Sanborn, B.M.3
  • 33
    • 9444226989 scopus 로고    scopus 로고
    • Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist
    • Dschietzig, T., C. Bartsch, V. Stangl, et al. 2004. Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist. FASEBJ. 18: 1536-1538.
    • (2004) FASEBJ , vol.18 , pp. 1536-1538
    • Dschietzig, T.1    Bartsch, C.2    Stangl, V.3
  • 34
    • 33947324489 scopus 로고    scopus 로고
    • Relaxin family peptide receptors: Former orphans reunite with their parent ligands to activate multiple signalling pathways
    • Halls, M.L., E.T. Van Der Westhuizen, R.A. Bathgate, et al. 2007. Relaxin family peptide receptors: Former orphans reunite with their parent ligands to activate multiple signalling pathways. Br. J. Pharmacol. 150: 677-691.
    • (2007) Br. J. Pharmacol , vol.150 , pp. 677-691
    • Halls, M.L.1    Van Der Westhuizen, E.T.2    Bathgate, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.