Influence of microinjections of D,L-homocysteic acid into the botzinger complex area on the cough reflex in the cat

Journal of Physiology and Pharmacology

Volumn 59, Issue SUPPL. 6, 2008, Pages 585-596

  Poliacek, I ^a,b   Corrie, L W ^a   Rose, M J ^a   Wang, C ^a   Bolser, D C ^a  

^a University of Florida College of Veterinary Medicine   (United States)

^b University Teaching Hospital in Martin   (Slovakia)

Author keywords

Botzinger complex; Cat; Cough; DLH; Ventral respiratory group

Indexed keywords

HOMOCYSTEIC ACID; DRUG DERIVATIVE; HOMOCYSTEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOTZINGER COMPLEX; BREATHING; BREATHING RATE; CAT; CONTROLLED STUDY; COUGHING; DISEASE DURATION; ELECTROMYOGRAPHY; END TIDAL CARBON DIOXIDE TENSION; ESOPHAGUS PRESSURE; FEMALE; INTERNEURON; MALE; MEAN ARTERIAL PRESSURE; MICROINJECTION; NERVE CELL; NONHUMAN; REFLEX; TRACHEOBRONCHIAL TREE; ANESTHESIA; ANIMAL; DRUG EFFECT; MEDULLA OBLONGATA; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL; STEREOTACTIC PROCEDURE;

ANESTHESIA; ANIMALS; CATS; COUGH; ELECTROMYOGRAPHY; FEMALE; HOMOCYSTEINE; LINEAR MODELS; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; REFLEX; STEREOTAXIC TECHNIQUES;

EID: 64549155284     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Merrill EG, Lipski J, Kubin L, Fedorko L. Origin of the expiratory inhibition of the nucleus tractus solitarius inspiratory neurones. Brain Res 1983; 263: 43-50.
2. Ezure K. Synaptic connections between medullary respiratory neurons and considerations on the genesis of respiratory rhythm. Prog Neurobiol 1990; 35: 429-450.
3. Jiang C, Lipski J. Extensive monosynaptic inhibition of ventral respiratory group neurons by augmenting neurons in the Botzinger complex in the cat. Exp Brain Res 1990; 81: 639-648.
4. Manabe M, Ezure K. Decrementing expiratory neurons of the Bötzinger complex. I. Response to lung inflation and axonal projection. Exp Brain Res 1988; 72: 150-158.
5. Shannon R, Baekey DM, Morris KF, Lindsey BG. Ventrolateral medullary respiratory network and a model of cough motor pattern generation. J Appl Physiol 1998; 84: 2020-2035.
6. Shannon R, Baekey DM, Morris KF, Li Z, Lindsey BG. Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. J Physiol 2000; 525: 207-224.
7. Jakus J, Tomori Z, Stránsky A. Neuronal Determinants of Breathing, Coughing and Related Motor Behaviours: Basics of Nervous Control and Reflex Mechanisms. Martin, Wist, 2004.
8. Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG. Production of reflex cough by brainstem respiratory networks. Pulm Pharmacol Ther 2004; 17: 369-376.
9. Balis UJ, Morris KF, Koleski J, Lindsey BG. Simulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train cross-correlation. Biol Cybern 1994; 70: 311-327.
10. Bolser DC, Poliacek I, Jakus J, Fuller DD, Davenport PW. Neurogenesis of cough, other airway defensive behaviors and breathing: a holarchical system? Respir Physiol Neurobiol 2006; 152: 255-265.
11. Bongianni F, Corda M, Fontana G, Pantaleo T. Expiration-related neurons in the caudal ventral respiratory group of the cat: influences of the activation of Botzinger complex neurons. Brain Res 1990; 526: 299-302.
12. Bongianni F, Mutolo D, Fontana GA, Pantaleo T. Discharge patterns of Bötzinger complex neurons during cough in the cat. Am J Physiol 1998; 274: R1015-R1024.
13. Bongianni F, Fontana G, Pantaleo T. Effects of electrical and chemical stimulation of the Bötzinger complex on respiratory activity in the cat. Brain Res 1988; 445: 254-261.
14. Bongianni F, Corda M, Fontana GA, Pantaleo T. Excitatory and depressant respiratory responses to chemical stimulation of the rostral ventrolateral medulla in the cat. Acta Physiol Scand 1993; 148: 315-325.
15. McCrimmon DR, Monnier A, Hayashi F, Zuperku EJ. Pattern formation and rhythm generation in the ventral respiratory group. Clin Exp Pharmacol Physiol 2000; 27: 126-131.
16. Poliacek I, Corrie LW, Wang C, Rose MJ, Bolser DC. Microinjection of DLH into the region of the caudal ventral respiratory column in the cat: evidence for an endogenous cough-suppressant mechanism. J Appl Physiol 2007; 102: 1014-1021.
17. Bolser DC, Hey JA, Chapman RW. Influence of central antitussive drugs on the cough motor pattern. J Appl Physiol 1999; 86: 1017-1024.
18. Lawn AM. The localization, by means of electrical stimulation, of the origin and path in the medulla oblongata of the motor nerve fibres of the rabbit oesophagus. J Physiol 1964; 174: 232-244.
19. Dampney RA. The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog Neurobiol 1994; 42: 197-227.
20. Korpas J, Tomori Z. Cough and other respiratory reflexes. New York, S Karger, Basel, 1979.
21. Tatár M, Korpas J, Polacek H, Zahradny V. Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetized cats. Respiration 1986; 49: 114-121.
22. Bolser DC, Davenport PW. Functional organization of the central cough generation mechanism. Pulm Pharmacol Ther 2002; 15: 221-225.
23. Hanacek J, Davies A, Widdicombe JG. Influence of lung stretch receptors on the cough reflex in rabbits. Respiration 1984; 45: 161-168.
24. Hanacek J, Tatar M, Widdicombe J. Regulation of cough by secondary sensory inputs. Respir Physiol Neurobiol 2006; 152: 282-297.
25. Lipski J, Bellingham MC, West MJ, Pilowsky P. Limitations of the technique of pressure microinjection of excitatory amino acids for evoking responses from localized regions of theCNS. J Neurosci Methods 1988; 26: 169-179.